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Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphocyte subpopulations block the mixed leukocyte reaction in man.
Open accessAbstract
Two major subsets of human T lymphocytes that are functionally analogous to the mouse Lyt-2+ and Lyt-2- subsets have been defined by their expression of two thymus-dependent membrane antigens, Leu-2 and Leu-3. Leu-2+,3- cells have suppressor/cytotoxic functions and Leu-2-,3+ cells have helper functions. These studies were designed to determine the effects of adding IgG1 monoclonal anti-Leu-2 and anti-Leu-3 antibodies to the mixed leukocyte reaction (MLR). At high concentrations, each antibody partially inhibited the proliferative response of unseparated T cells and abolished the response of the isolated subset having the appropriate phenotype. An IgG1 monoclonal antibody to HLA-A2 and an IgG2a antibody to Leu-1, a pan-T antigen, failed to inhibited the MLR. These results suggest that the Leu-2 and Leu-3 antigens may have a direct role in the mechanism whereby T cells recognize and respond to alloantigen.
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Cited by
Dialynas, D. P., Wilde, D. B., Marrack, P., Pierres, A., Wall, K. A., Havran, W., Otten, G., Loken, M. R., Pierres, M., Kappler, J., et al. (1983) · Immunological Reviews · doi:10.1111/j.1600-065x.1983.tb01083.x · Cited by 1,014
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Walker, C. M., Moody, D. J., Stites, D. P., & Levy, J. A. (1986) · Science · doi:10.1126/science.2431484 · Cited by 990
Rogers, J., Luber-Narod, J., Styren, S. D., & Civin, W. H. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80079-4 · Cited by 743
T Cell Subsets and the Recognition of MHC Class
Swain, S. L. (1983) · Immunological Reviews · doi:10.1111/j.1600-065x.1983.tb01087.x · Cited by 687
MADDON, P., LITTMAN, D., GODFREY, M., MADDON, D., CHESS, L., & AXEL, R. (1985) · Cell · doi:10.1016/s0092-8674(85)80105-7 · Cited by 658
Metadata
- Authors
- Engleman, E. G., Benike, C. J., Glickman, E., & Evans, R. L.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1981-07-01
- Volume
- 154
- Issue
- 1
- Pages
- 193-198
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2124568244
- Cited by
- 301
- References
- 0
- FWCI
- 15.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphocyte subpopulations block the mixed leukocyte reaction in man. https://app.cochat.ai/papers/10.1084/jem.154.1.193
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- Engleman, E. G., Benike, C. J., Glickman, E., & Evans, R. L. (1981). Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphocyte subpopulations block the mixed leukocyte reaction in man. The Journal of experimental medicine. https://doi.org/10.1084/jem.154.1.193
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
