The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Antibodies to laminin in Chagas' disease.
Open accessAbstract
We have found that sera from humans with Chagas' disease and Rhesus monkeys infected with Trypanosoma cruzi contain IgM and IgG antibodies, which react with structures in a variety of connective tissues. These antibodies react with laminin but not with various other purified connective tissue components like collagen types I, III, IV, and V, fibronectin, heparan sulfate (BM-1) proteoglycan, or chondronectin. The tissue-reacting antibodies were isolated by absorption to a laminin-Sepharose column. The bound fraction contained all the tissue-reacting antibodies. These antibodies strongly stained trypomastigotes and amastigotes, but weakly stained epimastigotes. These studies show that sera from T. cruzi-infected primates contain antilaminin antibodies, which may be produced by those host in response to a laminin-like molecule present in the parasite.
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Citations
Cites
Laminin–a glycoprotein from basement membranes
Timpl, R., Rohde, H., Robey, P. G., Rennard, S. I., Foidart, J. M., & Martin, G. R. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83607-4 · Cited by 2,378
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Recent studies on the structure and pathology of basement membranes
Abrahamson, D. R. (1986) · The Journal of Pathology · doi:10.1002/path.1711490402 · Cited by 254
Circulating heart-reactive antibodies in patients with myocarditis or cardiomyopathy
Neumann, D. A., Lynne Burek, C., Baughman, K. L., Rose, N. R., & Herskowitz, A. (1990) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(10)80331-6 · Cited by 191
Metadata
- Authors
- Szarfman, A., Terranova, V. P., Rennard, S. I., Foidart, J. M., de Fatima Lima, M., Scheinman, J. I., & Martin, G. R.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1982-04-01
- Volume
- 155
- Issue
- 4
- Pages
- 1161-1171
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2100639395
- Cited by
- 171
- References
- 1
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Antibodies to laminin in Chagas' disease. https://app.cochat.ai/papers/10.1084/jem.155.4.1161
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- Szarfman, A., Terranova, V. P., Rennard, S. I., Foidart, J. M., de Fatima Lima, M., Scheinman, J. I., & Martin, G. R. (1982). Antibodies to laminin in Chagas' disease. The Journal of experimental medicine. https://doi.org/10.1084/jem.155.4.1161
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
