The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Complement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus.
Open accessAbstract
This study reports quantitative information on the concentration of complement receptor for C3b and C4b (CR1) on erythrocytes from normal individuals and patients with immune complex disease. The measurements were performed by an immunoradiometric assay using monoclonal antibodies against CR1. The antibody specificity was confirmed by immunoprecipitation of CR1 from extracts of surface-labeled cells, by inhibition of rosette formation between B lymphocytes and the erythrocytes intermediate EAC14oxy23b, and by the characteristic distribution of the antigen among cells of human peripheral blood. The number of CR1 molecules in erythrocytes from 52 normal individuals was estimated as 1,410 +/- 620. No significant differences in CR1 levels were observed when individuals were grouped by sex, age, or blood groups. In patients with SLE and rheumatoid arthritis, the number of CR1 molecules per RBC was significantly lower, i.e., 600 +/- 307 and 903 +/- 417, respectively. CR1 levels were normal in asthmatics undergoing long-term treatment with prednisone. In SLE patients, significant correlations were found between CR1 levels, C4 hemolytic titers, and levels of circulating immune complexes. In two out of four patients with SLE, CR1 levels increased significantly during remission, showing that the deficiency is, at least in part, reversible. The deficiency in CR1 could be genetically controlled or could represent an epiphenomenon caused by the interaction of the receptor with a ligand present in the circulation of patients.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,221
Continuous cultures of fused cells secreting antibody of predefined specificity
KÖHLER, G., & MILSTEIN, C. (1975) · Nature · doi:10.1038/256495a0 · Cited by 17,229
A rapid method for the isolation of functional thymus‐derived murine lymphocytes
Julius, M. H., Simpson, E., & Herzenberg, L. A. (1973) · European Journal of Immunology · doi:10.1002/eji.1830031011 · Cited by 4,147
A better cell line for making hybridomas secreting specific antibodies
SHULMAN, M., WILDE, C. D., & KÖHLER, G. (1978) · Nature · doi:10.1038/276269a0 · Cited by 1,605
"Panning" for lymphocytes: a method for cell selection.
Wysocki, L. J., & Sato, V. L. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.6.2844 · Cited by 1,294
The Raji cell radioimmune assay for detecting immune complexes in human sera.
Theofilopoulos, A. N., Wilson, C. B., & Dixon, F. J. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108257 · Cited by 725
Fearon, D. (1980) · The Journal of Experimental Medicine · doi:10.1084/jem.152.1.20 · Cited by 644
A study of malignant tumours in Nigeria by short-term tissue culture
Pulvertaft, R. J. V. (1965) · Journal of Clinical Pathology · doi:10.1136/jcp.18.3.261 · Cited by 578
Third component of human complement: purification from plasma and physicochemical characterization
Tack, B. F., & Prahl, J. W. (1976) · Biochemistry · doi:10.1021/bi00665a028 · Cited by 516
Cited by
Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
the European Alzheimer's Disease Initiative Investigators, Lambert, J.-C., Heath, S., Even, G., Campion, D., Sleegers, K., Hiltunen, M., Combarros, O., Zelenika, D., Bullido, M. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.439 · Cited by 2,234
Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk
Efthymiou, A. G., & Goate, A. M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0184-x · Cited by 562
Medof, M. E., Kinoshita, T., & Nussenzweig, V (1984) · The Journal of experimental medicine · doi:10.1084/jem.160.5.1558 · Cited by 561
Self-citationThe Role of Complement and Its Receptor in the Elimination of Immune Complexes
Epstein, F. H., Schifferli, J. A., Ng, Y. C., & Peters, D. K. (1986) · New England Journal of Medicine · doi:10.1056/nejm198608213150805 · Cited by 396
Metadata
- Authors
- Iida, K., Mornaghi, R., & Nussenzweig, V
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1982-05-01
- Volume
- 155
- Issue
- 5
- Pages
- 1427-1438
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2121291030
- Cited by
- 339
- References
- 23
- FWCI
- 16.66
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Complement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus. https://app.cochat.ai/papers/10.1084/jem.155.5.1427
- The paper
- Iida, K., Mornaghi, R., & Nussenzweig, V. (1982). Complement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus. The Journal of experimental medicine. https://doi.org/10.1084/jem.155.5.1427
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
