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Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor.
Open accessAbstract
Anti-Mac-1 (M1/70), a rat monoclonal antibody that reacts with mouse and human macrophages, polymorphonuclear leukocytes (PMNL), and natural killer cells, selectively inhibited complement receptor-mediated rosetting by murine macrophages and human PMNL. Preincubation of macrophages with anti-Mac-1 inhibited formation of rosettes with sheep erythrocytes bearing IgM antibody and murine C3 fragments. No inhibition was observed when other monoclonal antibodies that react with macrophages (such as anti-Ly5, anti-H-2, or anti-pan-leukocyte) were tested at 10-fold higher concentrations. Anti-Mac-1 did not affect macrophage Fc receptor-mediated rosetting. Erythrocytes bearing homogeneous human C3 fragments C3b (EC3b) or C3bi (EC3bi) were used to test the specificity of the murine macrophage and human PMNL complement receptor inhibited by anti-Mac-1. In both cases, anti-Mac-1 inhibited CR3-mediated rosetting of EC3bi but not CR1-dependent rosetting of EC3b. The results show that Mac-1 is either identical to CR3 or closely associated with CR3 function. This is one of the first cases in which a monoclonal antibody-defined differentiation antigen has been associated with a specific cell surface function.
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Citations
Cited by
Biology of Natural Killer Cells
Trinchieri, G. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60664-1 · Cited by 2,902
Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.
Fingeroth, J. D., Weis, J. J., Tedder, T. F., Strominger, J. L., Biro, P. A., & Fearon, D. T. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.14.4510 · Cited by 939
Perry, V. H., Hume, D. A., & Gordon, S. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90215-5 · Cited by 902
Sanchez-Madrid, F., Nagy, J. A., Robbins, E., Simon, P., & Springer, T. A. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.6.1785 · Cited by 873
Self-citationMetlay, J. P., Witmer-Pack, M. D., Agger, R., Crowley, M. T., Lawless, D., & Steinman, R. M. (1990) · The Journal of experimental medicine · doi:10.1084/jem.171.5.1753 · Cited by 555
Metadata
- Authors
- Beller, D. I., Springer, T. A., & Schreiber, R. D.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1982-10-01
- Volume
- 156
- Issue
- 4
- Pages
- 1000-1009
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2105074038
- Cited by
- 606
- References
- 0
- FWCI
- 21.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Beller, D. I., Springer, T. A., & Schreiber, R. D. (1982). Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor. The Journal of experimental medicine. https://doi.org/10.1084/jem.156.4.1000
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