Cited by 281Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchReproductive Biology and Fertility

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure

Open access

Harrison, D E, Astle, C M·1982·The Journal of Experimental Medicine

DOI 10.1084/jem.156.6.1767PMC PMC2186863

Open this paper in CoChat — free account

Abstract

Long-term functional capacities of marrow cell lines were defined by competitive repopulation, a technique capable of detecting a small decline in repopulating abilities. There was little or no difference between cells from old and young donors, but a single serial transplantation caused a large decline in repopulating ability. Varying the numbers of marrow cells transplanted into the initial carrier from 10(5) to 10(7) did not alter the ability of the carrier's marrow cells to repopulate in competition with previously untransplanted cells. This ability was improved only in carriers that had received 10(8) marrow cells, although deleterious effects of transplantation were still present. These effects were not solely caused by cell damage from the transplantation procedure, because transplantation by parabiosis, or recovery from sublethal irradiation without transplantation, reduced repopulating abilities as much as transplanting 10(5) to 10(7) marrow cells. The transplantation effect also was not caused solely by irradiation, because the same effect appeared in unirradiated W/Wv carriers. The transplantation effect was more pronounced when donors were identified by hemoglobin type than by chromosome markers, implying that nonerythroid cell lines may be less affected by transplantation than erythroid precursor cells. When the effects of a lifetime of normal function and a single transplantation were compared, the latter caused 3-7 times more decline in repopulating abilities of phytohemagglutinin-responsive cell precursors, and at least 10-20 times more decline in erythroid cell precursors. Stem cell lines can be serially transplanted at least five times before losing their ability to repopulate and save lethally irradiated recipients or to cure genetically anemic mice. Therefore, if transplantation causes an acceleration of the normal aging process, these figures suggest that stem cells should be able to function normally through at least 15-50 life spans.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1084/jem.156.6.1767

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876
The relationship between the spleen colony-forming cell and the haemopoietic stem cell.
Schofield, R. (1978) · PubMed · Cited by 2,304
Properties of haematopoietic stem cells surviving 5-fluorouracil treatment: evidence for a pre-CFU-S cell?
HODGSON, G. S., & Bradley, T. R. (1979) · Nature · doi:10.1038/281381a0 · Cited by 509
Competitive repopulation: a new assay for long-term stem cell functional capacity
Harrison, D. (1980) · Blood · doi:10.1182/blood.v55.1.77.77 · Cited by 329
Self-citation
Decline in colony‐forming ability of marrow cells subjected to serial transplantation into irradiated mice
Siminovitch, L., Till, J. E., & McCulloch, E. A. (1964) · Journal of Cellular and Comparative Physiology · doi:10.1002/jcp.1030640104 · Cited by 275
TISSUE GRAFTING AND RADIATION
MICKLEM, H. S., & LOUITT, J. F. (1967) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196704000-00037 · Cited by 224
Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging.
Harrison, D. E., Astle, C. M., & Delaittre, J. A. (1978) · The Journal of Experimental Medicine · doi:10.1084/jem.147.5.1526 · Cited by 224
Self-citation
A Comparison of Marrow Transplantation with Chemotherapy for Children with Acute Lymphoblastic Leukemia in Second or Subsequent Remission
Johnson, F. L., Thomas, E. D., Clark, B. S., Chard, R. L., Hartmann, J. R., & Storb, R. F. (1981) · New England Journal of Medicine · doi:10.1056/nejm198110083051502 · Cited by 215
Immunologic deficiencies in senescence. I. Characterization of intrinsic deficiencies.
Price, G. B., & Makinodan, T. (1972) · PubMed · Cited by 181
Proliferative capacity of murine hematopoietic stem cells.
Hellman, S., Botnick, L. E., Hannon, E. C., & Vigneulle, R. M. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.1.490 · Cited by 148

Flagged first, then by citations

Show all 39 references

Sorted by citations

Items 101–200 of 281

Clinical application of hematopoietic progenitor cell expansion: current status and future prospects
Devine, S. M., Lazarus, H. M., & Emerson, S. G. (2003) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1703813 · Cited by 66
Unique Differentiation Programs of Human Fetal Liver Stem Cells Shown Both In Vitro and In Vivo in NOD/SCID Mice
Nicolini, F. E., Holyoake, T. L., Cashman, J. D., Chu, P. P., Lambie, K., & Eaves, C. J. (1999) · Blood · doi:10.1182/blood.v94.8.2686.420k15_2686_2695 · Cited by 66
Liver and marrow of adult mdr-1a/1b−/− mice show normal generation, function, and multi-tissue trafficking of primitive hematopoietic cells
Uchida, N., Leung, F. Y. K., & Eaves, C. J. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(02)00879-2 · Cited by 66
Hematopoietic stem cells and aging
Globerson, A. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00069-2 · Cited by 66
Cycle initiation and colony formation in culture by murine marrow cells with long-term reconstituting potential in vivo
Trevisan, M., Yan, X., & Iscove, N. (1996) · Blood · doi:10.1182/blood.v88.11.4149.4149 · Cited by 65
Loss of hematopoietic stem cell self-renewal after bone marrow transplantation
Mauch, P. M., & Hellmän, S. (1989) · Blood · doi:10.1182/blood.v74.2.872.872 · Cited by 64
Impact of Donor Age on Outcome after Allogeneic Hematopoietic Cell Transplantation
Rezvani, A. R., Storer, B. E., Guthrie, K. A., Schoch, H. G., Maloney, D. G., Sandmaier, B. M., & Storb, R. F. (2014) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2014.09.021 · Cited by 67
Cellular Memory and Hematopoietic Stem Cell Aging
Kamminga, L. M., & de Haan, G. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0345 · Cited by 63
Telomeres, senescence, and hematopoietic stem cells
Zimmermann, S., & Martens, U. M. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0469-4 · Cited by 66
From stem cells to lymphocytes; biology and transplantation
Aguila, H. L., Akashi, K., Domen, J., Gondy, K. L., Lagasse, E., Wright, D. E., Wassman, I. L., Morrison, S. J., Mebius, R. E., Shizuu, J., et al. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb00971.x · Cited by 63
Does younger donor age affect the outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation for hematologic malignancies beneficially?
Mehta, J., Gordon, L. I., Tallman, M. S., Winter, J. N., Evens, A. M., Frankfurt, O., WILLIAMS, S. F., Grinblatt, D. L., Kaminer, L. S., Meagher, R., et al. (2006) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705388 · Cited by 62
Human Cord Blood Progenitors Sustain Thymic T-Cell Development and a Novel Form of Angiogenesis
Crisá, L., Cirulli, V., Smith, K. A., Ellisman, M. H., Torbett, B. E., & Salomon, D. R. (1999) · Blood · doi:10.1182/blood.v94.11.3928 · Cited by 61
Short- and Long-Term Multilineage Repopulating Hematopoietic Stem Cells in Late Fetal and Newborn Mice: Models for Human Umbilical Cord Blood
Harrison, D. E., & Astle, C. M. (1997) · Blood · doi:10.1182/blood.v90.1.174 · Cited by 59
Self-citation
Delayed Immune Aging in Diet-Restricted B6CBAT6 Fl Mice Is Associated With Preservation of Naive T Cells
Chen, J., Astle, C. M., & Harrison, D. E. (1998) · The Journals of Gerontology Series A · doi:10.1093/gerona/53a.5.b330 · Cited by 57
Self-citation
Aging, Idiotype Repertoire Shifts, and Compartmentalization of the Mucosal-Associated Lymphoid System
Wade, A., & Szewczuk, M. R. (1984) · Advances in immunology · doi:10.1016/s0065-2776(08)60901-3 · Cited by 57
Leukemia inhibitory factor upregulates cytokine expression by a murine stromal cell line enabling the maintenance of highly enriched competitive repopulating stem cells
Szilvassy, S. J., Weller, K., Lin, W., Sharma, A., Ho, A., Tsukamoto, A., Hoffman, R., Leiby, K., & Gearing, D. P. (1996) · Blood · doi:10.1182/blood.v87.11.4618.bloodjournal87114618 · Cited by 57
Analyzing hematopoietic stem cell homing, lodgment, and engraftment to better understand the bone marrow niche
Heazlewood, S. Y., Oteiza, A., Cao, H., & Nilsson, S. K. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12329 · Cited by 55
Mathematical model of granulocytopoiesis and chronic myelogenous leukemia.
FOKAS, A. S., Keller, J. B., & Clarkson, B. (1991) · PubMed · Cited by 56
In vitro analysis of age‐related changes in the developmental potential of bone marrow thymocyte progenitors
Sharp, A., Kukulansky, T., & Globerson, A. (1990) · European Journal of Immunology · doi:10.1002/eji.1830201203 · Cited by 56
Thrombopoietic potential and serial repopulating ability of murine hematopoietic stem cells constitutively expressing interleukin 11.
Hawley, R. G., Hawley, T. S., Fong, A. Z. C., Quinto, C., Collins, M., Leonard, J. P., & Goldman, S. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10297 · Cited by 55
Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita
Goldman, F. D., Aubert, G., Klingelhutz, A. J., Hills, M., Cooper, S., Hamilton, W. S., Schlueter, A. J., Lambie, K., Eaves, C. J., & Lansdorp, P. M. (2008) · Blood · doi:10.1182/blood-2007-10-120204 · Cited by 54
Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors
Cao, Y., Wagers, A. J., Karsunky, H., Zhao, H. F., Reeves, R. E., Wong, R. J., Stevenson, D. K., Weissman, I. L., & Contag, C. H. (2008) · Blood · doi:10.1182/blood-2007-12-127621 · Cited by 53
Role of p53 in Hematopoietic Recovery After Cytotoxic Treatment
Wlodarski, P. K., Wasik, M. A., Ratajczak, M. Z., Sevignani, C., Hoser, G., Kawiak, J., Gewirtz, A. M., Calabretta, B., & Skórski, T. (1998) · Blood · doi:10.1182/blood.v91.8.2998.2998_2998_3006 · Cited by 53
Clonogenic hemopoietic precursors in bone marrow transplantation
Messner, H., Curtis, J. E., Minden, M., Tritchler, D., Lockwood, G. A., Takahashi, T., Lépine, J., Jamal, N., Tweeddale, M., & Wandl, U. B. (1987) · Blood · doi:10.1182/blood.v70.5.1425.1425 · Cited by 52
Primitive Neural Stem Cells in the Adult Mammalian Brain Give Rise to GFAP-Expressing Neural Stem Cells
Sachewsky, N., Leeder, R., Xu, W., Rose, K., Yu, F., van der Kooy, D., & Morshead, C. M. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.04.008 · Cited by 51
Serum differentially modulates the clonal growth and differentiation of cultured limbal and corneal epithelium.
Kruse, F. E., & Tseng, S. C. G. (1993) · PubMed · Cited by 51
Stem Cells Use Distinct Self-renewal Programs at Different AgesPreprint
Levi, B. P., & Morrison, S. J. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.049 · Cited by 54
Rejuvenation of cerebromicrovascular function in aged mice through heterochronic parabiosis: insights into neurovascular coupling and the impact of young blood factors
Gulej, R., Nyúl‐Tóth, Á., Csík, B., Petersen, B., Faakye, J., Negri, S., Chandragiri, S. S., Mukli, P., Yabluchanskiy, A., Conley, S. M., et al. (2023) · GeroScience · doi:10.1007/s11357-023-01039-2 · Cited by 51
Linking age-related defects in B lymphopoiesis to the aging of hematopoietic stem cells
Miller, J. P., & Allman, D. (2005) · Seminars in Immunology · doi:10.1016/j.smim.2005.05.003 · Cited by 50
An in vivo competitive repopulation assay for various sources of human hematopoietic stem cells
Rosler, E. S., Brandt, J., Chute, J. P., & Hoffman, R. (2000) · Blood · doi:10.1182/blood.v96.10.3414 · Cited by 50
What is a stem cell?
Slack, J. M. W. (2018) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.323 · Cited by 50
Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling
Kiss, T., Nyúl‐Tóth, Á., Gulej, R., Tarantini, S., Csípő, T., Mukli, P., Ungvari, A., Balasubramanian, P., Yabluchanskiy, A., Benyó, Z., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00519-1 · Cited by 48
Partially differentiated ex vivo expanded cells accelerate hematologic recovery in myeloablated mice transplanted with highly enriched long- term repopulating stem cells
Szilvassy, S. J., Weller, K., Chen, B., Juttner, C. A., Tsukamoto, A. S., & Hoffman, R. (1996) · Blood · doi:10.1182/blood.v88.9.3642.bloodjournal8893642 · Cited by 48
PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia
McRae, H. M., Garnham, A. L., Hu, Y., Witkowski, M. T., Corbett, M. A., Dixon, M. P., May, R. E., Sheikh, B. N., Chiang, W., Kueh, A. J., et al. (2019) · Blood · doi:10.1182/blood-2018-07-860726 · Cited by 49
Erythropoietic repopulating ability of stem cells from long-term marrow culture
Harrison, D., Lerner, C. P., & Spooncer, E. (1987) · Blood · doi:10.1182/blood.v69.4.1021.1021 · Cited by 47
Self-citation
RNAi screen for telomerase reverse transcriptase transcriptional regulators identifies HIF1α as critical for telomerase function in murine embryonic stem cells
Coussens, M. J., Davy, P. M. C., Brown, L., Foster, C., Andrews, W. H., Nagata, M., & Allsopp, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913834107 · Cited by 43
Abnormalities of myeloid progenitor cells after "successful" bone marrow transplantation.
Li, S., Champlin, R. E., Fitchen, J. H., & Gale, R. P. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111679 · Cited by 43
Epigenetic Control of Hematopoietic Stem Cell Aging The Case of Ezh2
de Haan, G., & GERRITS, A. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1392.008 · Cited by 42
Clonal diversity of the stem cell compartment
Müller‐Sieburg, C. E., & Sieburg, H. B. (2006) · Current Opinion in Hematology · doi:10.1097/01.moh.0000231421.00407.65 · Cited by 40
Telomere dysfunction and stem cell ageing
Ju, Z., & Rudolph, K. L. (2007) · Biochimie · doi:10.1016/j.biochi.2007.09.006 · Cited by 42
Effect of Age on the Frequency, Cell Cycle, and Lineage Maturation of Rhesus Monkey (Macaca mulatta) CD34+ and Hematopoietic Progenitor Cells
Lee, C. C. I., Fletcher, M. D., & Tarantal, A. F. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000169975.30339.32 · Cited by 39
Bone marrow transplantation in mice as a tool for studying the role of hematopoietic cells in metabolic and cardiovascular diseases
Aparicio-Vergara, M., Shiri‐Sverdlov, R., de Haan, G., & Hofker, M. H. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.05.030 · Cited by 40
Progress in the development of systems for in vitro expansion of human hematopoietic stem cells
Hoffman, R. (1999) · Current Opinion in Hematology · doi:10.1097/00062752-199905000-00010 · Cited by 39
Young blood-mediated cerebromicrovascular rejuvenation through heterochronic parabiosis: enhancing blood-brain barrier integrity and capillarization in the aged mouse brain
Gulej, R., Nyúl‐Tóth, Á., Csík, B., Patai, R., Petersen, B., Negri, S., Chandragiri, S. S., Shanmugarama, S., Mukli, P., Yabluchanskiy, A., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01154-8 · Cited by 39
Comparison of haemopoiesis in young and old mice
Schofield, R., Dexter, T. M., Lord, B. I., & Testa, N. G. (1986) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(86)90100-4 · Cited by 38
Reactive Oxygen Species Limit the Ability of Bone Marrow Stromal Cells to Support Hematopoietic Reconstitution in Aging Mice
Khatri, R., Krishnan, S., Roy, S., Chattopadhyay, S., Kumar, V., & Mukhopadhyay, A. (2016) · Stem Cells and Development · doi:10.1089/scd.2015.0391 · Cited by 37
Genomic Aging, Clonal Hematopoiesis, and Cardiovascular Disease
Natarajan, P. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318181 · Cited by 35
Cellular aging leads to functional heterogeneity of hematopoietic stem cells: a modeling perspective
Glauche, I., Thielecke, L., & Roeder, I. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00692.x · Cited by 35
Searching for stem cells
Iscove, N. N. (1990) · Nature · doi:10.1038/347126a0 · Cited by 35
Novel Management of Acute or Secondary Biliary Liver Conditions Using Hepatically Differentiated Human Dental Pulp Cells
Ishkitiev, N., Yaegaki, K., Imai, T., Tanaka, T., Fushimi, N., Mitev, V., Okada, M., Tominaga, N., Ono, S., & Ishikawa, H. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2014.0162 · Cited by 34
Gene therapy and gene editing strategies for hemoglobinopathies
Lidonnici, M. R., & Ferrari, G. (2018) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2017.12.001 · Cited by 34
Programmed ageing: decline of stem cell renewal, immunosenescence, and Alzheimer's disease
Lathe, R., & Clair, D. S. (2023) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12959 · Cited by 37
The function of hematopoietic stem cells is altered by both genetic and inflammatory factors in lupus mice
Niu, H., Fang, G., Tang, Y., Xie, L., Yang, H., Morel, L. M., Diamond, B., & Zou, Y.-R. (2013) · Blood · doi:10.1182/blood-2012-05-433755 · Cited by 35
Intraesophageal MnSOD-plasmid liposome enhances engraftment and self-renewal of bone marrow derived progenitors of esophageal squamous epithelium
Niu, Y., Epperly, M. W., Shen, H., Smith, T. L., Wang, H., & Greenberger, J. S. (2007) · Gene Therapy · doi:10.1038/sj.gt.3303089 · Cited by 34
Cocultivation of umbilical cord blood cells with endothelial cells leads to extensive amplification of competent CD34+CD38− cells
Rosler, E. S., Brandt, J., Chute, J. P., & Hoffman, R. (2000) · Experimental Hematology · doi:10.1016/s0301-472x(00)00177-6 · Cited by 34
Introduction to Stem Cell Biology in Vitro: Threshold to the Future
Eaves, C. J., Miller, C., Conneally, E., Audet, J., Oostendorp, R. A. J., CASHMANP, J., Zandstra, P. W., Rose‐John, S., Piret, J. M., & Eaves, A. C. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08447.x · Cited by 34
Aging and the Germ Line: Where Mortality and Immortality Meet
Jones, D. L. (2007) · Stem Cell Reviews and Reports · doi:10.1007/s12015-007-0009-3 · Cited by 34
The Influence of Therapeutic Radiation on the Patterns of Bone Marrow in Ovary-Intact and Ovariectomized Mice
Hui, S. K., Sharkey, L. C., Kidder, L. S., Zhang, Y., Fairchild, G., Coghill, K., Xian, C. J., & Yee, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042668 · Cited by 32
Age related changes in hemopoietic capacity of bone marrow cells
Sharp, A., Zipori, D., Toledo, J., Tal, S., Resnitzky, P., & Globerson, A. (1989) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(89)90029-8 · Cited by 31
Aging is associated with an expansion of CD49fhi mammary stem cells that show a decline in function and increased transformation potential
Dong, Q., Gao, H., Shi, Y., Zhang, F., Gu, X., Wu, A., Wang, D., Chen, Y., Bandyopadhyay, A., Yeh, I.-T., et al. (2016) · Aging · doi:10.18632/aging.101082 · Cited by 29
Epigenetic biomarkers in aging and longevity: Current and future application
Izadi, M., Sadri, N., Abdi, A., Serajian, S., Jalalei, D., & Tahmasebi, S. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122842 · Cited by 32
The GOD of Hematopoietic Stem Cells: A Clonal Diversity Model of the Stem Cell Compartment
Müller‐Sieburg, C. E., & Sieburg, H. B. (2006) · Cell Cycle · doi:10.4161/cc.5.4.2487 · Cited by 29
Evidence for a qualitative hierarchy within the Hoechst-33342 ‘side population’ (SP) of murine bone marrow cells
Robinson, S. N., Seina, S. M., Gohr, J. C., KUSZYNSKI, C. A., & Sharp, J. G. (2005) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704881 · Cited by 29
Ultimate erythropoietic repopulating abilities of fetal, young adult, and old adult cells compared using repeated irradiation.
Harrison, D. E., Astle, C. M., & Lerner, C. P. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.160.3.759 · Cited by 29
Self-citation
The Positive Regulatory Effect of TGF-β2 on Primitive Murine Hemopoietic Stem and Progenitor Cells Is Dependent on Age, Genetic Background, and Serum Factors
Henckaerts, E., Langer, J., Orenstein, J., & Snoeck, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2486 · Cited by 28
Potential Relationship between Inadequate Response to DNA Damage and Development of Myelodysplastic Syndrome
Zhou, T., Chen, P., Gu, J. H., Bishop, A. J. R., Scott, L., Hasty, P., & Rebel, V. I. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16010966 · Cited by 26
Hematopoietic responses to stress conditions in young dogs compared with elderly dogs
Zaucha, J. M., Yu, C., Mathioudakis, G., Seidel, K. D., Georges, G. E., Sale, G., Little, M.-T., Torok‐Storb, B., & Storb, R. F. (2001) · Blood · doi:10.1182/blood.v98.2.322 · Cited by 27
Hepatocytes break the rules of senescence in serial transplantation studies. Is there a limit to their replicative capacity?
Fausto, N. (1997) · Europe PMC (PubMed Central) · Cited by 25
Gene therapy approaches for stem cell protection
Greenberger, J. S. (2007) · Gene Therapy · doi:10.1038/sj.gt.3303004 · Cited by 25
Skeletal (“Mesenchymal”) Stem Cells for Tissue Engineering
Robey, P. G., Kuznetsov, S. A., Riminucci, M., & Bianco, P. (2007) · Methods in molecular medicine · doi:10.1007/978-1-59745-443-8_5 · Cited by 25
Chemotherapy prior to autologous bone marrow transplantation impairs long-term engraftment in mice
Noach, E. J. K., Ausema, A., van Os, R. P., Akkerman, I., Koopal, S., Weersing, E., Dontje, B., Vellenga, E., & de Haan, G. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(03)00068-7 · Cited by 25
Quantitation of Murine and Human Hematopoietic Stem Cells by Limiting-Dilution Analysis in Competitively Repopulated Hosts
Szilvassy, S. J., Nicolini, F. E., Eaves, C. J., & Miller, C. (2003) · Humana Press eBooks · doi:10.1385/1-59259-140-x:167 · Cited by 25
Molecular and Cellular Aspects of Macrophage Aging
Sebastián, C., Lloberas, J., & Celada, A. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_46 · Cited by 24
Marrow frequency of rat long-term repopulating cells: evidence that marrow hematopoietic stem cell concentration may be inversely proportional to species body weight
McCarthy, K. F. (2003) · Blood · doi:10.1182/blood-2002-10-3026 · Cited by 23
Thymocytopoiesis in aging: the bone marrow-thymus axis
Globerson, A. (1997) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(96)00747-9 · Cited by 23
Lnk deficiency partially mitigates hematopoietic stem cell aging
Bersenev, A., Rozenova, K., Balcerek, J., Jiang, J., Wu, C., & Tong, W. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00862.x · Cited by 24
Mice Transgenic for the Human CGM6 Gene Express Its Product, the Granulocyte Marker CD66b, Exclusively in Granulocytes
Eades‐Perner, A., Thompson, J., van der Putten, H., & Zimmermann, W. (1998) · Blood · doi:10.1182/blood.v91.2.663 · Cited by 22
The stem cell concept revisited: Self-renewal capacity is a dynamic property of hemopoietic cells
Grossman, Z. (1986) · Leukemia Research · doi:10.1016/0145-2126(86)90246-8 · Cited by 21
Thymocyte progenitors in ageing
Globerson, A. (1994) · Immunology Letters · doi:10.1016/0165-2478(94)00059-x · Cited by 21
Evaluating Functional Abilities of Primitive Hematopoietic Stem Cell Populations
Harrison, D. E. (1992) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-76912-2_2 · Cited by 21
Self-citation
Functional Assays for Hematopoietic Stem Cell Self-Renewal
Perry, J. M., & Li, L. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-691-7_3 · Cited by 18
Visualizing hematopoiesis as a stochastic process
Xu, J., Wang, Y., Guttorp, P. M., & Abkowitz, J. L. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018023705 · Cited by 17
Endothelial BMAL1 decline during aging leads to bone loss by destabilizing extracellular fibrillin-1
Yin, Y., Tang, Q., Yang, J., Gui, S., Zhang, Y., Shen, Y., Zhou, X., Yu, S., Chen, G., Sun, J., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci176660 · Cited by 17
Epimorphic regeneration of the mouse digit tip is finite
Dolan, C. P., Yang, T., Zimmel, K. N., Imholt, F. M., Qureshi, O., Falck, A. R., Gregory, J., Mayes, M., Ritchie, K., Koester, H., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02741-2 · Cited by 17
Comprehensive Nanorobotic Control of Human Morbidity and Aging
Freitas, R. A. (2010) · The Future of Aging · doi:10.1007/978-90-481-3999-6_23 · Cited by 16
Smurf2 regulates hematopoietic stem cell self‐renewal and aging
Ramkumar, C., Kong, Y., Trabucco, S. E., Gerstein, R. M., & Zhang, H. (2014) · Aging Cell · doi:10.1111/acel.12195 · Cited by 17
Nutraceutical intervention reverses the negative effects of blood from aged rats on stem cells
Bickford, P. C., Kaneko, Y., Grimmig, B. A., Pappas, C. A., Small, B. J., Sanberg, C. D., Sanberg, P. R., Tan, J. R., & Shytle, R. D. (2015) · AGE · doi:10.1007/s11357-015-9840-7 · Cited by 16
Immune Reconstitution after Haploidentical Donor and Umbilical Cord Blood Allogeneic Hematopoietic Cell Transplantation
Elmariah, H., Brunstein, C. G., & Bejanyan, N. (2021) · Life · doi:10.3390/life11020102 · Cited by 15
Chromosomal Number Aberrations and Transformation in Adult Mouse Retinal Stem Cells In Vitro
Djojosubroto, M. W., Bollotte, F., Wirapati, P., Radtke, F., Stamenkovic, I., & Arsenijévic, Y. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-3091 · Cited by 17
Novel cellular approaches to repair of neurodegenerative disease: From Sertoli cells to umbilical cord blood stem cells
Sanberg, P. R., Willing, A. E., & Cahill, D. W. (2002) · Neurotoxicity Research · doi:10.1080/10298420290015917 · Cited by 15
Stem cells in normal growth and disease.
Dexter, T. M. (1987) · BMJ · doi:10.1136/bmj.295.6607.1192 · Cited by 15
Effect of donor age on long-term culture of bone marrow in vitro
Lipschitz, D. A., & Udupa, K. B. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90179-9 · Cited by 15
Indirect effects of X-irradiation on proliferation and osteogenic potential of bone marrow mesenchymal stem cells in a local irradiated rat model
Sun, R., Zhu, G., Wang, J., Tong, L., & Zhai, J. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6464 · Cited by 14
Impaired PBPC collection in patients with myeloma after high-dose melphalan
Jansen, J., Thompson, J. M., Dugan, M. J., Wiemann, M. C., Hanks, S., Greenspan, A., & Akard, L. P. (2004) · Cytotherapy · doi:10.1080/14653240410005023 · Cited by 13
Early Hemopoietic and Stromal Precursor Cells
Chertkov, J. L. (1986) · International review of cytology · doi:10.1016/s0074-7696(08)61278-4 · Cited by 13
Hematopoietic Stem Cells: Self-Renewing or Aging?
de Haan, G. (2002) · Cells Tissues Organs · doi:10.1159/000057689 · Cited by 13
Haemopoietic Multipotential Stem Cells in Culture
Johnson, G. R. (1984) · Clinics in Haematology · doi:10.1016/s0308-2261(21)00425-2 · Cited by 13
Reduced repression of cytokine signaling ameliorates age‐induced decline in hematopoietic stem cell function
Norddahl, G. L., Wahlestedt, M., Gisler, S., Sigvardsson, M., & Bryder, D. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00863.x · Cited by 12
Clonal analysis of thymus-repopulating cells presents direct evidence for self-renewal division of human hematopoietic stem cells
Yahata, T., Yumino, S., Seng, Y., Miyatake, H., Uno, T., Muguruma, Y., Ito, M., Miyoshi, H., Kato, S., Hotta, T., et al. (2006) · Blood · doi:10.1182/blood-2006-02-002204 · Cited by 12
A non-redundant function of cyclin E1 in hematopoietic stem cells
Campaner, S., Viale, A., Fazio, S., Doni, M., Franco, F., D’Artista, L., Sardella, D., Pelicci, P. G., & Amati, B. B. (2013) · Cell Cycle · doi:10.4161/cc.26584 · Cited by 12

Authors: Harrison, D. E., & Astle, C. M.
Affiliations: Jackson Laboratory (US)
Venue: The Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 1982-12-01
Volume: 156
Issue: 6
Pages: 1767-1779
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.156.6.1767
PMC: PMC2186863
OpenAlex: W2097857054
Cited by: 281
References: 39
Citations by year: 2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 4 · 2016: 10 · 2015: 6 · 2014: 9 · 2013: 9 · 2012: 8
FWCI: 4.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Funders: National Institute on Aging
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: hematopoietic stem cells, competitive repopulation, serial transplantation, donor age, parabiosis, sublethal irradiation, erythroid precursors, stem cell aging, bone marrow transplantation, hemoglobin types
MeSH terms: Aging, Animals, Bone Marrow Cells, Cell Count, Erythropoiesis, Female, Hematopoietic Stem Cells, Male, Mice, Inbred CBA, Mice, Inbred C57BL, Parabiosis, Transplantation, Bone Marrow Transplantation, Hematopoietic Stem Cell Transplantation, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks