Cited by 281Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchReproductive Biology and Fertility

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure

Open access

Harrison, D E, Astle, C M·1982·The Journal of Experimental Medicine

DOI 10.1084/jem.156.6.1767PMC PMC2186863

Open this paper in CoChat — free account

Abstract

Long-term functional capacities of marrow cell lines were defined by competitive repopulation, a technique capable of detecting a small decline in repopulating abilities. There was little or no difference between cells from old and young donors, but a single serial transplantation caused a large decline in repopulating ability. Varying the numbers of marrow cells transplanted into the initial carrier from 10(5) to 10(7) did not alter the ability of the carrier's marrow cells to repopulate in competition with previously untransplanted cells. This ability was improved only in carriers that had received 10(8) marrow cells, although deleterious effects of transplantation were still present. These effects were not solely caused by cell damage from the transplantation procedure, because transplantation by parabiosis, or recovery from sublethal irradiation without transplantation, reduced repopulating abilities as much as transplanting 10(5) to 10(7) marrow cells. The transplantation effect also was not caused solely by irradiation, because the same effect appeared in unirradiated W/Wv carriers. The transplantation effect was more pronounced when donors were identified by hemoglobin type than by chromosome markers, implying that nonerythroid cell lines may be less affected by transplantation than erythroid precursor cells. When the effects of a lifetime of normal function and a single transplantation were compared, the latter caused 3-7 times more decline in repopulating abilities of phytohemagglutinin-responsive cell precursors, and at least 10-20 times more decline in erythroid cell precursors. Stem cell lines can be serially transplanted at least five times before losing their ability to repopulate and save lethally irradiated recipients or to cure genetically anemic mice. Therefore, if transplantation causes an acceleration of the normal aging process, these figures suggest that stem cells should be able to function normally through at least 15-50 life spans.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1084/jem.156.6.1767

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876
The relationship between the spleen colony-forming cell and the haemopoietic stem cell.
Schofield, R. (1978) · PubMed · Cited by 2,304
Properties of haematopoietic stem cells surviving 5-fluorouracil treatment: evidence for a pre-CFU-S cell?
HODGSON, G. S., & Bradley, T. R. (1979) · Nature · doi:10.1038/281381a0 · Cited by 509
Competitive repopulation: a new assay for long-term stem cell functional capacity
Harrison, D. (1980) · Blood · doi:10.1182/blood.v55.1.77.77 · Cited by 329
Self-citation
Decline in colony‐forming ability of marrow cells subjected to serial transplantation into irradiated mice
Siminovitch, L., Till, J. E., & McCulloch, E. A. (1964) · Journal of Cellular and Comparative Physiology · doi:10.1002/jcp.1030640104 · Cited by 275
TISSUE GRAFTING AND RADIATION
MICKLEM, H. S., & LOUITT, J. F. (1967) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196704000-00037 · Cited by 224
Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging.
Harrison, D. E., Astle, C. M., & Delaittre, J. A. (1978) · The Journal of Experimental Medicine · doi:10.1084/jem.147.5.1526 · Cited by 224
Self-citation
A Comparison of Marrow Transplantation with Chemotherapy for Children with Acute Lymphoblastic Leukemia in Second or Subsequent Remission
Johnson, F. L., Thomas, E. D., Clark, B. S., Chard, R. L., Hartmann, J. R., & Storb, R. F. (1981) · New England Journal of Medicine · doi:10.1056/nejm198110083051502 · Cited by 215
Immunologic deficiencies in senescence. I. Characterization of intrinsic deficiencies.
Price, G. B., & Makinodan, T. (1972) · PubMed · Cited by 181
Proliferative capacity of murine hematopoietic stem cells.
Hellman, S., Botnick, L. E., Hannon, E. C., & Vigneulle, R. M. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.1.490 · Cited by 148

Show all 39 references

Sorted by citations

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair
Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908
Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1
Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.
Vaziri, H., Dragowska, W., Allsopp, R. C., Thomas, T. E., Harley, C. B., & Lansdorp, P. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9857 · Cited by 1,132
Biology of Hematopoietic Stem Cells and Progenitors: Implications for Clinical Application
Kondo, M., Wagers, A. J., Manz, M. G., Prohaska, S. S., Scherer, D. C., Beilhack, G. F., Shizuru, J. A., & Weissman, I. L. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141007 · Cited by 1,025
Mouse Models in Aging Research
FLURKEY, K., MCURRER, J., & HARRISON, D. (2007) · The Mouse in Biomedical Research · doi:10.1016/b978-012369454-6/50074-1 · Cited by 723
Self-citation
The aging of hematopoietic stem cells
Morrison, S. J., Wandycz, A. M., Akashi, K., Globerson, A., & Weissman, I. L. (1996) · Nature Medicine · doi:10.1038/nm0996-1011 · Cited by 853
The Biology of Hematopoietic Stem Cells
Morrison, S. J., Uchida, N., & Weissman, I. L. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.000343 · Cited by 794
Age-Associated Characteristics of Murine Hematopoietic Stem Cells
Sudo, K., Ema, H., Morita, Y., & Nakauchi, H. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1273 · Cited by 722
Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
Beerman, I., Bhattacharya, D., Zandi, S., Sigvardsson, M., Weissman, I. L., Bryder, D., & Rossi, D. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000834107 · Cited by 711
Stem cells, ageing and the quest for immortality
Rando, T. A. (2006) · Nature · doi:10.1038/nature04958 · Cited by 695
Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers.
Sutherland, H. J., Lansdorp, P. M., Henkelman, D. H., Eaves, A., & Eaves, C. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.9.3584 · Cited by 646
Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/W mice
Dick, J. E., Magli, M. C., Huszar, D., Phillips, R. A., & Bernstein, A. (1985) · Cell · doi:10.1016/s0092-8674(85)80102-1 · Cited by 637
Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes.
Overturf, K., Al-Dhalimy, M., Ou, C. N., Finegold, M. J., & Grompe, M. (1997) · Europe PMC (PubMed Central) · Cited by 599
Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.Preprint
Sauvageau, G., Þorsteinsdóttir, U., Eaves, C. J., Lawrence, H. J., Largman, C., Lansdorp, P. M., & Humphries, R. K. (1995) · Genes & Development · doi:10.1101/gad.9.14.1753 · Cited by 586
Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors
Keller, G. M., Paige, C. J., Gilboa, E., & Wagner, E. F. (1985) · Nature · doi:10.1038/318149a0 · Cited by 572
Neural Stem Cell Detection, Characterization, and Age-Related Changes in the Subventricular Zone of Mice
Maslov, A. Y., Barone, T. A., Plunkett, R. J., & Pruitt, S. C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4608-03.2004 · Cited by 522
Stem cells: the generation and maintenance of cellular diversity
Hall, P. A., & Watt, F. M. (1989) · Development · doi:10.1242/dev.106.4.619 · Cited by 506
Clonal dynamics of haematopoiesis across the human lifespan
Mitchell, E., Chapman, M. S., Williams, N., Dawson, K. J., Mende, N., Calderbank, E. F., Jung, H., Mitchell, T. J., Coorens, T. H. H., Spencer, D. H., et al. (2022) · Nature · doi:10.1038/s41586-022-04786-y · Cited by 538
Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
Beerman, I., Bock, C., Garrison, B. S., Smith, Z. D., Gu, H., Meissner, A., & Rossi, D. J. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.017 · Cited by 485
Epithelial stem cells in vivo
Potten, C. S., & Morris, R. J. (1988) · Journal of Cell Science · doi:10.1242/jcs.1988.supplement_10.4 · Cited by 441
Aging of hematopoietic stem cells
de Haan, G., & Lazare, S. S. (2018) · Blood · doi:10.1182/blood-2017-06-746412 · Cited by 432
Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon–dependent exhaustion
Sato, T., Onai, N., Yoshihara, H., Arai, F., Suda, T., & Ohteki, T. (2009) · Nature Medicine · doi:10.1038/nm.1973 · Cited by 426
Demand-adapted regulation of early hematopoiesis in infection and inflammation
Takizawa, H., Boettcher, S., & Manz, M. G. (2012) · Blood · doi:10.1182/blood-2011-12-380113 · Cited by 420
Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin
Kimura, S. H., Roberts, A. W., Metcalf, D., & Alexander, W. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1195 · Cited by 387
The polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion
Kamminga, L. M., Bystrykh, L. V., de Boer, A., Houwer, S., Douma, J., Weersing, E., Dontje, B., & de Haan, G. (2006) · Blood · doi:10.1182/blood-2005-09-3585 · Cited by 376
The tortoise and the hair: slow-cycling cells in the stem cell race
Fuchs, E. (2009) · Cell · doi:10.1016/j.cell.2009.05.002 · Cited by 371
Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment
Kovtonyuk, L. V., Fritsch, K., Feng, X., Manz, M. G., & Takizawa, H. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00502 · Cited by 371
Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells
Esplin, B. L., Shimazu, T., Welner, R. S., Garrett, K. P., Nie, L., Zhang, Q., Humphrey, M. B., Yang, Q., Borghesi, L., & Kincade, P. W. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003438 · Cited by 336
The Cellular and Subcellular Bases of Immunosenescence
Thoman, M. L., & Weigle, W. O. (1989) · Advances in immunology · doi:10.1016/s0065-2776(08)60655-0 · Cited by 318
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
Viale, A., Franco, F., Orleth, A., Cambiaghi, V., Giuliani, V., Bossi, D., Ronchini, C., Ronzoni, S., Muradore, I., Monestiroli, S., et al. (2008) · Nature · doi:10.1038/nature07618 · Cited by 314
Mouse Strain-Dependent Changes in Frequency and Proliferation of Hematopoietic Stem Cells During Aging: Correlation Between Lifespan and Cycling Activity
de Haan, G., NIJHOF, W., & Zant, G. E. V. (1997) · Blood · doi:10.1182/blood.v89.5.1543 · Cited by 300
Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis
Rodrigues, N. P. (2005) · Blood · doi:10.1182/blood-2004-08-2989 · Cited by 302
Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor
Molineux, G., Pojda, Z., Hampson, I., Lord, B. I., & Dexter, T. M. (1990) · Blood · doi:10.1182/blood.v76.10.2153.2153 · Cited by 292
Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation
Takizawa, H., Regoes, R. R., Boddupalli, C. S., Bonhoeffer, S., & Manz, M. G. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101643 · Cited by 309
Deterministic regulation of hematopoietic stem cell self-renewal and differentiation
Müller‐Sieburg, C. E., Cho, R. H., Thoman, M. L., Adkins, B., & Sieburg, H. B. (2002) · Blood · doi:10.1182/blood.v100.4.1302.h81602001302_1302_1309 · Cited by 282
Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells
Cao, X., Wu, X., Frassica, D. A., Yu, B., Pang, L., Xian, L., Wan, M., Lei, W., Armour, M., Tryggestad, E. J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015350108 · Cited by 256
Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties
Bowie, M. B., Kent, D. G., Dykstra, B. J., McKnight, K. D., McCaffrey, L., Hoodless, P. A., & Eaves, C. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700460104 · Cited by 266
Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo
Jeong, M., Park, H. J., Celik, H., Ostrander, E. L., Reyes, J. M., Guzman, A., Rodriguez, B., Lei, Y., Lee, Y., Ding, L., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.025 · Cited by 243
The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
Dumble, M. L., Moore, L. M., Chambers, S. M., Geiger, H., Zant, G. E. V., Goodell, M. A., & Donehower, L. A. (2006) · Blood · doi:10.1182/blood-2006-03-010413 · Cited by 249
Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system.
Bernad, A., Kopf, M., Kulbacki, R., Weich, N., Koehler, G., & Gutiérrez-Ramos, J. (1994) · Immunity · doi:10.1016/s1074-7613(94)80014-6 · Cited by 242
The problem of clonality in aplastic anemia: Dr Dameshek's riddle, restated [see comments]
Young, N. S. (1992) · Blood · doi:10.1182/blood.v79.6.1385.bloodjournal7961385 · Cited by 230
The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts
Rebel, V. I., Miller, C., Eaves, C. J., & Lansdorp, P. (1996) · Blood · doi:10.1182/blood.v87.8.3500.bloodjournal8783500 · Cited by 223
Hematopoietic stem cells expand during serial transplantation in vivo without apparent exhaustion
Iscove, N. N., & Nawa, K. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00341-1 · Cited by 214
Functional heterogeneity of the hematopoietic microenvironment: rare stromal elements maintain long-term repopulating stem cells
Wineman, J., Moore, K. A., Lemischka, I. R., & Müller‐Sieburg, C. E. (1996) · Blood · doi:10.1182/blood.v87.10.4082.bloodjournal87104082 · Cited by 210
Number and continuous proliferative pattern of transplanted primitive immunohematopoietic stem cells.
Harrison, D. E., Astle, C. M., & Lerner, C. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.3.822 · Cited by 205
Self-citation
The Repopulation Potential of Hepatocyte Populations Differing in Size and Prior Mitotic Expansion
Overturf, K., Al-Dhalimy, M., Finegold, M. J., & Grompe, M. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65531-9 · Cited by 202
Quantification of Self-Renewal Capacity in Single Hematopoietic Stem Cells from Normal and Lnk-Deficient Mice
Ema, H., Sudo, K., Seita, J., Matsubara, A., Morita, Y., Osawa, M., Takatsu, K., Τακακι, S., & Nakauchi, H. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.019 · Cited by 215
In vivo telomere dynamics of human hematopoietic stem cells
Notaro, R., Cimmino, A., Tabarini, D., Rotoli, B., & Luzzatto, L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13782 · Cited by 195
Telomere Shortening Accompanies Increased Cell Cycle Activity during Serial Transplantation of Hematopoietic Stem Cells
Allsopp, R., Cheshier, S. H., & Weissman, I. L. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.8.917 · Cited by 195
Understanding intrinsic hematopoietic stem cell aging
Mejía-Ramírez, E., & Florian, M. C. (2019) · Haematologica · doi:10.3324/haematol.2018.211342 · Cited by 206
Two phases of engraftment established by serial bone marrow transplantation in mice
Jones, R., Celano, P., Sharkis, S. J., & Sensenbrenner, L. (1989) · Blood · doi:10.1182/blood.v73.2.397.bloodjournal732397 · Cited by 186
Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2
Bersenev, A., Wu, C., Balcerek, J., & Tong, W. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35808 · Cited by 194
Nfatc1 orchestrates aging in hair follicle stem cells
Keyes, B. E., Segal, J. P., Heller, E., Lien, W., Chang, C.-Y., Guo, X., Oristian, D., Zheng, D., & Fuchs, E. V. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320301110 · Cited by 185
IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice
Kovtonyuk, L. V., Caiado, F., Garcia-Martin, S., Manz, E.-M., Helbling, P., Takizawa, H., Boettcher, S., Al-Shahrour, F., Nombela-Arrieta, C., Slack, E., et al. (2022) · Blood · doi:10.1182/blood.2021011570 · Cited by 166
Normal stem cells and cancer stem cells: similar and different
Shackleton, M. J. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.04.002 · Cited by 168
Evidence of both ontogeny and transplant dose-regulated expansion of hematopoietic stem cells in vivo
Pawliuk, R., Eaves, C. J., & Humphries, R. K. (1996) · Blood · doi:10.1182/blood.v88.8.2852.bloodjournal8882852 · Cited by 158
Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells
Allsopp, R. C., Morin, G. B., Horner, J. W., DePinho, R., Harley, C. B., & Weissman, I. L. (2003) · Nature Medicine · doi:10.1038/nm0403-369 · Cited by 155
Enhanced In Vivo Regenerative Potential of HOXB4-Transduced Hematopoietic Stem Cells With Regulation of Their Pool Size
Þorsteinsdóttir, U., Sauvageau, G., & Humphries, R. K. (1999) · Blood · doi:10.1182/blood.v94.8.2605.420k19_2605_2612 · Cited by 154
Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus.
Hawley, R. G., Fong, A. Z. C., Burns, B. F., & Hawley, T. S. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.4.1149 · Cited by 153
Dynamics of the male germline stem cell population during aging of Drosophila melanogaster
Wallenfang, M. R., Nayak, R. R., & DiNardo, S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00221.x · Cited by 146
Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose γ-irradiation
Yu, H. M., Shen, H., Yuan, Y., XuFeng, R., Hu, X., Garrison, S. P., Zhang, L., Yu, J., Zambetti, G. P., & Cheng, T. (2010) · Blood · doi:10.1182/blood-2009-10-248278 · Cited by 144
Establishment of a Normal Hematopoietic and Leukemia Stem Cell HierarchyPreprint
Chao, M. P., Seita, J., & Weissman, I. L. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.031 · Cited by 146
Effects of transplantation on the primitive immunohematopoietic stem cell.
Harrison, D. E., Stone, M., & Astle, C. M. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.2.431 · Cited by 131
Self-citation
Clonal hematopoiesis: Mutation-specific adaptation to environmental change
Florez, M. A., Tran, B. T., Wathan, T. K., DeGregori, J., Pietras, E. M., & King, K. Y. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.05.006 · Cited by 129
Impaired hematopoietic stem cell functioning after serial transplantation and during normal aging
Kamminga, L. M., van Os, R., Ausema, A., Noach, E. J. K., Weersing, E., Dontje, B., Vellenga, E., & de Haan, G. (2005) · STEM CELLS · doi:10.1634/stemcells.2004-0066 · Cited by 128
Hematopoietic stem cell exhaustion impacted by p18INK4C and p21Cip1/Waf1 in opposite manners
Yu, H., Yuan, Y., Shen, H., & Cheng, T. (2006) · Blood · doi:10.1182/blood-2005-02-0685 · Cited by 127
After the bomb drops: A new look at radiation-induced multiple organ dysfunction syndrome (MODS)
Williams, J. P., & McBride, W. H. (2011) · International Journal of Radiation Biology · doi:10.3109/09553002.2011.560996 · Cited by 125
Long-term erythropoietic repopulating ability of old, young, and fetal stem cells.
Harrison, D. E. (1983) · The Journal of Experimental Medicine · doi:10.1084/jem.157.5.1496 · Cited by 123
Self-citation
The Critical Role of Inflammation in the Pathogenesis and Progression of Myeloid Malignancies
Craver, B. M., Alaoui, K. E., Scherber, R. M., & Fleischman, A. G. (2018) · Cancers · doi:10.3390/cancers10040104 · Cited by 120
PR-domain–containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function
Zhang, Y., Stehling-Sun, S., Lezon-Geyda, K., Juneja, S. C., Coillard, L., Chatterjee, G., Wuertzer, C. A., Camargo, F. D., & Perkins, A. S. (2011) · Blood · doi:10.1182/blood-2011-02-334680 · Cited by 108
Hematopoietic stem cell aging and self-renewal
Dykstra, B. J., & de Haan, G. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0529-9 · Cited by 109
Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivoPreprint
Pfau, S. J., Silberman, R. E., Knouse, K. A., & Amon, A. (2016) · Genes & Development · doi:10.1101/gad.278820.116 · Cited by 104
Stem Cells, Redox Signaling, and Stem Cell Aging
Liang, R., & Ghaffari, S. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5300 · Cited by 106
Long- and short-lived murine hematopoietic stem cell clones individually identified with retroviral integration markers
Capel, B., Hawley, R. G., & Mintz, B. (1990) · Blood · doi:10.1182/blood.v75.12.2267.2267 · Cited by 106
Hemopoiesis in healthy old people and centenarians: well-maintainedresponsiveness of CD34+ cells to hemopoietic growth factors and remodelingof cytokine network
Bagnara, G. P., Bonsi, L., Strippoli, P., Bonifazi, F., Tonelli, R., D’Addato, S., Paganelli, R., Scala, E., Fagiolo, U., Monti, D., et al. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.2.b61 · Cited by 100
Phenotypic heterogeneity among stromal cell lines from mouse bone marrow disclosed in their extracellular matrix composition and interactions with normal and leukemic cells
Zipori, D., Toledo, J., & von der Mark, K. (1985) · Blood · doi:10.1182/blood.v66.2.447.447 · Cited by 100
Aging of hematopoietic stem cells is regulated by the stem cell niche
Wagner, W., Horn, P., Bork, S., & Ho, A. D. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.04.007 · Cited by 103
Continuous in vitro generation of multipotential stem cell clones from src-infected cultures
Spooncer, E., Boettiger, D. E., & Dexter, T. M. (1984) · Nature · doi:10.1038/310228a0 · Cited by 99
Bone Marrow–Derived Stem Cells and Radiation Response
Greenberger, J. S., & Epperly, M. W. (2009) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2008.11.006 · Cited by 97
Hematopoietic Stem Cell Aging: Wrinkles In Stem Cell Potential
Chambers, S. M., & Goodell, M. A. (2007) · Stem Cell Reviews and Reports · doi:10.1007/s12015-007-0027-1 · Cited by 92
Is telomerase activity in cancer due to selection of stem cells and differentiation arrest?
Greaves, M. F. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)30016-4 · Cited by 93
Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms
Meng, A., Wang, Y., Brown, S. A., Zant, G. E. V., & Zhou, D. (2003) · Experimental Hematology · doi:10.1016/j.exphem.2003.08.014 · Cited by 90
Primitive hematopoietic cells in murine bone marrow express the CD34 antigen
Morel, F., Szilvassy, S. J., Travis, M. A., Chen, B., & Galy, A. H. M. (1996) · Blood · doi:10.1182/blood.v88.10.3774.bloodjournal88103774 · Cited by 88
Hematopoietic Stem Cells and the Aging Hematopoietic System
Gazit, R., Weissman, I. L., & Rossi, D. J. (2008) · Seminars in Hematology · doi:10.1053/j.seminhematol.2008.07.010 · Cited by 84
Regulatory pathways associated with bone loss and bone marrow adiposity caused by aging, chemotherapy, glucocorticoid therapy and radiotherapy.
Georgiou, K. R., Hui, S. K., & Xian, C. J. (2012) · Europe PMC (PubMed Central) · Cited by 80
Bone Marrow-Derived Cells: The Influence of Aging and Cellular Senescence
Beausejour, C. M. (2007) · Springer eBooks · doi:10.1007/978-3-540-68976-8_4 · Cited by 79
Genetic programs regulating HSC specification, maintenance and expansion
Lessard, J. A., Faubert, A., & Sauvageau, G. (2004) · Oncogene · doi:10.1038/sj.onc.1207940 · Cited by 76
Telomeres, telomerase, and hematopoietic stem cell biology
Greenwood, M. J., & Lansdorp, P. M. (2003) · Archives of Medical Research · doi:10.1016/j.arcmed.2003.07.003 · Cited by 79
Clonal dynamics of haematopoiesis across the human lifespanPreprint
Mitchell, E., Chapman, M. S., Williams, N., Dawson, K. J., Mende, N., Calderbank, E. F., Jung, H., Mitchell, T. J., Coorens, T. H. H., Spencer, D. H., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.16.456475 · Cited by 74
Quantitative Trait Analysis Reveals Transforming Growth Factor-β2 as a Positive Regulator of Early Hematopoietic Progenitor and Stem Cell Function
Langer, J., Henckaerts, E., Orenstein, J., & Snoeck, H. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20030980 · Cited by 73
Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood
Kiss, T., Tarantini, S., Csípő, T., Balasubramanian, P., Nyúl‐Tóth, Á., Yabluchanskiy, A., Wren, J. D., Garman, L., Huffman, D. M., Csiszár, A., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00180-6 · Cited by 75
Hematopoietic progenitor/stem cells immortalized byLhx2 generate functional hematopoietic cells in vivo
Pinto‐do‐Ó, P., Richter, K., & Carlsson, L. (2002) · Blood · doi:10.1182/blood.v99.11.3939 · Cited by 73
T cell cultures and the Hayflick limit
Effros, R. B., & Walford, R. L. (1984) · Human Immunology · doi:10.1016/0198-8859(84)90006-5 · Cited by 74
Effects of aging on hematopoietic stem and progenitor cells
Waterstrat, A., & Zant, G. E. V. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.002 · Cited by 72
Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role?
Allsopp, R., & Weissman, I. L. (2002) · Oncogene · doi:10.1038/sj.onc.1205314 · Cited by 71
Enhanced Myeloid Progenitor Cell Cycling and Apoptosis in Mice Lacking the Chemokine Receptor, CCR2
Reid, S., Ritchie, A., Boring, L. F., Gosling, J., Cooper, S. H., Hangoc, G., Charo, I. F., & Broxmeyer, H. E. (1999) · Blood · doi:10.1182/blood.v93.5.1524 · Cited by 70
Chemotherapy and Stem Cell Transplantation Increase p16 INK4a Expression, a Biomarker of T-cell Aging
Wood, W. A., Krishnamurthy, J., Mitin, N., Torrice, C., Parker, J. S., Snavely, A. C., Shea, T. C., Serody, J. S., & Sharpless, N. E. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.08.029 · Cited by 73
Permanent loss in stem cell self renewal capacity following stress to the marrow
Mauch, P. M., Rosenblatt, M., & Hellmän, S. (1988) · Blood · doi:10.1182/blood.v72.4.1193.1193 · Cited by 68
Effect of age on lymphocyte proliferation
McCarron, M., Osborne, Y., Story, C. J., Dempsey, J. L., Turner, D. R., & Morley, A. A. (1987) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(87)90041-8 · Cited by 68
Bone marrow toxicity induced by oral benzo[a]pyrene: Protection resides at the level of the intestine and liver
Legraverend, C., Harrison, D. E., Ruscetti, F. W., & Nebert, D. W. (1983) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(83)90157-6 · Cited by 67
Self-citation

Authors: Harrison, D. E., & Astle, C. M.
Affiliations: Jackson Laboratory (US)
Venue: The Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 1982-12-01
Volume: 156
Issue: 6
Pages: 1767-1779
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.156.6.1767
PMC: PMC2186863
OpenAlex: W2097857054
Cited by: 281
References: 39
Citations by year: 2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 4 · 2016: 10 · 2015: 6 · 2014: 9 · 2013: 9 · 2012: 8
FWCI: 4.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Funders: National Institute on Aging
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: hematopoietic stem cells, competitive repopulation, serial transplantation, donor age, parabiosis, sublethal irradiation, erythroid precursors, stem cell aging, bone marrow transplantation, hemoglobin types
MeSH terms: Aging, Animals, Bone Marrow Cells, Cell Count, Erythropoiesis, Female, Hematopoietic Stem Cells, Male, Mice, Inbred CBA, Mice, Inbred C57BL, Parabiosis, Transplantation, Bone Marrow Transplantation, Hematopoietic Stem Cell Transplantation, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks