The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.
Open accessAbstract
Recent studies suggested that the clonally unique Ti epitopes defined by non-cross-reactive monoclonal antibodies might represent the variable regions of the antigen receptor. Here we determine whether such anti-Ti antibodies could trigger clonal T cell activation. Anticlonotypic monoclonal antibodies to the 49/43-kdalton heterodimer of a given clone or antibodies to the 20/25-kdalton membrane associated monomorphic T3 molecule selectively induce proliferation and IL-2 secretion when linked to a solid support. In contrast, anti-T4 and anti-T8 antibodies under the same conditions have no effect. In conclusion, these results imply that anticlonotypic antibody functions in a fashion analogous to antigen and further support the notion that the T3-Ti molecular complex represents the antigen receptor on human T lymphocytes.
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Citations
Cites
T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity
Gillis, S., Ferm, M. M., Ou, W., & Smith, K. A. (1978) · The Journal of Immunology · doi:10.4049/jimmunol.120.6.2027 · Cited by 3,273
Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose
Ey, P. L., Prowse, S. J., & Jenkin, C. R. (1978) · Immunochemistry · doi:10.1016/0161-5890(78)90070-6 · Cited by 2,685
Meuer, S. C., Fitzgerald, K. A., Hussey, R. E., Hodgdon, J. C., Schlossman, S. F., & Reinherz, E. L. (1983) · The Journal of experimental medicine · doi:10.1084/jem.157.2.705 · Cited by 837
Self-citationOKT3: A monoclonal anti-human T lymphocyte antibody with potent mitogenic properties
Van Wauwe, J. P., DeMay, J. R., & Goossens, J. G. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.125.5.2359.a · Cited by 711
Meuer, S. C., Schlossman, S. F., & Reinherz, E. L. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.14.4395 · Cited by 605
Self-citationEvidence for the T3-associated 90K heterodimer as the T-cell antigen receptor
Meuer, S. C., Acuto, O., Hussey, R. E., Hodgdon, J. C., Fitzgerald, K. A., Schlossman, S. F., & Reinherz, E. L. (1983) · Nature · doi:10.1038/303808a0 · Cited by 466
Self-citationSurface Structures Involved in Target Recognition by Human Cytotoxic T Lymphocytes
Meuer, S. C., Hussey, R. E., Hodgdon, J. C., Hercend, T., Schlossman, S. F., & Reinherz, E. L. (1982) · Science · doi:10.1126/science.6981845 · Cited by 238
Self-citationA monoclonal antibody blocking human T cell function
Reinherz, E. L., Hussey, R. E., & Schlossman, S. F. (1980) · European Journal of Immunology · doi:10.1002/eji.1830101006 · Cited by 235
Self-citation
Cited by
Hybrid antibodies can target sites for attack by T cells
Staerz, U. D., Kanagawa, O., & Bevan, M. J. (1985) · Nature · doi:10.1038/314628a0 · Cited by 492
Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody
Perez, P., Hoffman, R. W., Shaw, S., Bluestone, J. A., & Segal, D. M. (1985) · Nature · doi:10.1038/316354a0 · Cited by 337
Identification of the components of the murine T cell antigen receptor complex
Samelson, L. (1985) · Cell · doi:10.1016/0092-8674(85)90027-3 · Cited by 337
Pantaleo, G., Olive, D., Harris, D., Poggi, A., Moretta, L., & Moretta, A. (1986) · European Journal of Immunology · doi:10.1002/eji.1830161228 · Cited by 28
Metadata
- Authors
- Meuer, S. C., Hodgdon, J. C., Hussey, R. E., Protentis, J. P., Schlossman, S. F., & Reinherz, E. L.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1983-09-01
- Volume
- 158
- Issue
- 3
- Pages
- 988-993
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2134090908
- Cited by
- 423
- References
- 8
- FWCI
- 15.77
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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