The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.
Open accessAbstract
Monoclonal antibodies were produced against a human cytotoxic T cell clone, CT8III (specificity: HLA-A3), with the view of defining clonally restricted (clonotypic) surface molecules involved in its antigen recognition function. Two individual antibodies, termed anti-Ti1A and anti-Ti1B, reacted exclusively with the CT8III clone when tested on a panel of 80 additional clones from the same donor, resting or activated T cells, B cells, macrophages, thymocytes, or other hematopoietic cells. More importantly, the two antibodies inhibited cell-mediated killing and antigen-specific proliferation of the CT8III clone but did not affect the functions of any other clone tested. This inhibition was not secondary to generalized abrogation of the CT8III clone's function, because interleukin 2 responsiveness was enhanced. To examine the relationship of the structures defined by anti-clonotypic antibodies with known T cell surface molecules, antibody-induced modulation studies and competitive binding assays were performed. The results indicated that the clonotypic structures were associated with, but distinct from, the 20,000-mol wt T3 molecule expressed on all mature T lymphocytes. Moreover, in contrast to anti-T3, anti-Ti1A and anti-Ti1B each immunoprecipitated two molecules of 49,000 and 43,000-mol wt from 131I-labeled CT8III cells under reducing conditions. The development of monoclonal antibodies to such polymorphic T cell surface structures should provide important probes to further define the surface receptor for antigen.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,221
Reinherz, E. L., Kung, P. C., Goldstein, G., Levey, R. H., & Schlossman, S. F. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1588 · Cited by 1,630
Self-citationThe differentiation and function of human T lymphocytes
Reinherz, E. L., & Schlossman, S. F. (1980) · Cell · doi:10.1016/0092-8674(80)90072-0 · Cited by 1,530
Self-citationBenacerraf, B., & McDevitt, H. O. (1972) · Science · doi:10.1126/science.175.4019.273 · Cited by 1,182
Zinkernagel, R. M., & Doherty, P. C. (1975) · The Journal of experimental medicine · doi:10.1084/jem.141.6.1427 · Cited by 628
Meuer, S. C., Schlossman, S. F., & Reinherz, E. L. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.14.4395 · Cited by 605
Self-citationKurosawa, Y., von Boehmer, H., Haas, W., Sakano, H., Trauneker, A., & Tonegawa, S. (1981) · Nature · doi:10.1038/290565a0 · Cited by 313
Does OKT3 monoclonal antibody react with an antigen-recognition structure on human T cells?
Chang, T. W., Kung, P. C., Gingras, S. P., & Goldstein, G. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.3.1805 · Cited by 299
Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+.
Krensky, A. M., Reiss, C. S., Mier, J. W., Strominger, J. L., & Burakoff, S. J. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.7.2365 · Cited by 240
Cited by
T-cell antigen receptor genes and T-cell recognition
Davis, M. M., & Bjorkman, P. J. (1988) · Nature · doi:10.1038/334395a0 · Cited by 3,202
Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144
Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor
Meuer, S. C., Acuto, O., Hussey, R. E., Hodgdon, J. C., Fitzgerald, K. A., Schlossman, S. F., & Reinherz, E. L. (1983) · Nature · doi:10.1038/303808a0 · Cited by 466
Self-citationAntigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.
Meuer, S. C., Hodgdon, J. C., Hussey, R. E., Protentis, J. P., Schlossman, S. F., & Reinherz, E. L. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.3.988 · Cited by 423
Self-citationCross, S. L., Feinberg, M. B., Wolf, J. B., Holbrook, N. J., Wong-Staal, F., & Leonard, W. J. (1987) · Cell · doi:10.1016/0092-8674(87)90754-9 · Cited by 414
Metadata
- Authors
- Meuer, S. C., Fitzgerald, K. A., Hussey, R. E., Hodgdon, J. C., Schlossman, S. F., & Reinherz, E. L.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1983-02-01
- Volume
- 157
- Issue
- 2
- Pages
- 705-719
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2106719152
- Cited by
- 837
- References
- 15
- FWCI
- 52.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Meuer, S. C., Fitzgerald, K. A., Hussey, R. E., Hodgdon, J. C., Schlossman, S. F., & Reinherz, E. L. (1983). Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex. The Journal of experimental medicine. https://doi.org/10.1084/jem.157.2.705
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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