The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma.
Open accessAbstract
Neopterin, a compound derived from GTP, represents a precursor molecule of biopterin that is an essential cofactor in neurotransmitter synthesis. We have recently reported that in vivo as well as in vitro immune responses are accompanied by an increased release of neopterin and that this phenomenon can be used for the biochemical monitoring of diseases accompanied by hyperimmune stimulation. This article deals with the cellular origin and the control of this immune response-associated neopterin release in vitro. Using highly purified or monoclonal cellular reagents we demonstrate that macrophages (M phi) stimulated with supernatants from activated T cells release large amounts of neopterin into culture supernatants. Further experiments involving induction of neopterin release from M phi with various human recombinant interferons (IFNs) or neutralization of the effect of T cell supernatants with various monoclonal anti-IFN antibodies revealed immune IFN as the active principle. It thus appears that a metabolic pathway so far exclusively known in context with the generation of an essential cofactor of neurotransmitter-synthesis during immune responses is also activated in M phi under stringent control by immune IFN-like lymphokines.
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Cites
Systemic Lupus Erythematosus: Presence in Human Serum of an Unusual Acid-Labile Leukocyte Interferon
Preble, O. T., Black, R. J., Friedman, R. M., Klippel, J. H., & Vilček, J. (1982) · Science · doi:10.1126/science.6176024 · Cited by 459
THE STRUCTURE OF THE PHENYLALANINE-HYDROXYLATION COFACTOR
Kaufman, S. (1963) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.50.6.1085 · Cited by 376
Acid-Labile Human Leukocyte Interferon in Homosexual Men with Kaposi's Sarcoma and Lymphadenopathy
DeStefano, E., Friedman, R. M., Friedman‐Kien, A. E., Goedert, J. J., Henriksen-DeStefano, D., Preble, O. T., SONNABEND, J. A., & Vilček, J. (1982) · The Journal of Infectious Diseases · doi:10.1093/infdis/146.4.451 · Cited by 326
Hyperphenylalaninemia Due to a Deficiency of Biopterin: A Variant Form of Phenylketonuria
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Huber, C. H., Fuchs, D., Hausen, A., Margreiter, R., Reibnegger, G. J., Spielberger, M., & WACHTER, H. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.130.3.1047 · Cited by 152
Self-citationDetermination of neopterine in human urine by reversed-phase high-performance liquid chromatography
Hausen, A., Fuchs, D., König, K., et al. (1982) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)80356-4 · Cited by 113
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Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
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Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective
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Iron status and the outcome of HIV infection: an overview
Gordeuk, V. R., Delanghe, J. R., Langlois, M. R., & Boelaert, J. R. (2001) · Journal of Clinical Virology · doi:10.1016/s1386-6532(00)00134-7 · Cited by 124
Iron Chelation Therapy for Malaria
Mabeza, G. F., Loyevsky, M., Gordeuk, V. R., & Weiss, G. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00037-0 · Cited by 111
Metadata
- Authors
- Huber, C., Batchelor, J. R., Fuchs, D., Hausen, A., Lang, A., Niederwieser, D., Reibnegger, G., Swetly, P., Troppmair, J., & Wachter, H.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1984-07-01
- Volume
- 160
- Issue
- 1
- Pages
- 310-316
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2165233139
- Cited by
- 1,084
- References
- 6
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma. https://app.cochat.ai/papers/10.1084/jem.160.1.310
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- Huber, C., Batchelor, J. R., Fuchs, D., Hausen, A., Lang, A., Niederwieser, D., Reibnegger, G., Swetly, P., Troppmair, J., & Wachter, H. (1984). Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma. The Journal of experimental medicine. https://doi.org/10.1084/jem.160.1.310
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
