The DOI matches its Crossref record.
Systemic Lupus Erythematosus: Presence in Human Serum of an Unusual Acid-Labile Leukocyte Interferon
Abstract
A previously undescribed species of human leukocyte, or alpha, interferon is present in the serum of many patients with systemic lupus erythematosus. It was shown to be α-interferon by neutralization with specific antiserums, affinity column chromatography, and antiviral activity on bovine cells. However, 23 of 30 interferon samples tested were inactivated by incubation at p H 2, a characteristic of human "immune," or gamma, interferon. Multiple samples of interferon from the same patient had similar biological properties, but samples from different patients were not all identical, suggesting that several variants of this species of human α-interferon may exist.
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Citations
Cited by
ROLE OF ABERRANT HLA-DR EXPRESSION AND ANTIGEN PRESENTATION IN INDUCTION OF ENDOCRINE AUTOIMMUNITY
Bottazzo, G., Hanafusa, T., Pujol-Borrell, R., & Feldmann, M. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90629-3 · Cited by 1,256
Toll-like receptors in systemic autoimmune disease
Marshak-Rothstein, A. (2006) · Nature Reviews Immunology · doi:10.1038/nri1957 · Cited by 1,116
Huber, C., Batchelor, J. R., Fuchs, D., Hausen, A., Lang, A., Niederwieser, D., Reibnegger, G., Swetly, P., Troppmair, J., & Wachter, H. (1984) · The Journal of experimental medicine · doi:10.1084/jem.160.1.310 · Cited by 1,084
Hu, X., Chakravarty, S. D., & Ivashkiv, L. B. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00707.x · Cited by 303
Circulating interferon-α levels and hypertriglyceridemia in the acquired immunodeficiency syndrome.
Grunfeld, C., Kotler, D. P., Shigenaga, J. K., Doerrler, W., Tierney, A., Wang, J., Pierson, R. N., & Feingold, K. R. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90536-7 · Cited by 286
Metadata
- Authors
- Preble, O. T., Black, R. J., Friedman, R. M., Klippel, J. H., & Vilček, J.
- Venue
- Science
- Published
- 1982-04-23
- Volume
- 216
- Issue
- 4544
- Pages
- 429-431
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2031097604
- Cited by
- 459
- References
- 0
- FWCI
- 39.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Systemic Lupus Erythematosus: Presence in Human Serum of an Unusual Acid-Labile Leukocyte Interferon. https://app.cochat.ai/papers/10.1126/science.6176024
- The paper
- Preble, O. T., Black, R. J., Friedman, R. M., Klippel, J. H., & Vilček, J. (1982). Systemic Lupus Erythematosus: Presence in Human Serum of an Unusual Acid-Labile Leukocyte Interferon. Science. https://doi.org/10.1126/science.6176024
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
