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Epitopes of streptococcal M proteins shared with cardiac myosin.
Open accessAbstract
We present evidence that M proteins from three different serotypes of group A streptococci share epitopes with cardiac myosin. Rabbit antisera evoked by a purified fragment of type 5 M protein crossreacted with myosin, but not alpha-tropomyosin, actin, or myosin light chains. In enzyme-linked immunosorbent assays, the myosin-crossreactive antibodies were totally inhibited by type 5 M protein and partially inhibited by types 6 and 19 M proteins. The affinity-purified myosin antibodies opsonized type 5 streptococci, indicating that they were directed against protective M protein epitopes on the surface of the organisms. Immunoblot analyses demonstrated the binding of the crossreactive antibodies to myosin heavy chains. Sera from patients with acute rheumatic fever showed significantly stronger reactions with myosin than did sera from their siblings, hospitalized controls, or patients with poststreptococcal glomerulonephritis.
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Citations
Cited by
Group A Streptococcal Infections and Acute Rheumatic Fever
Bisno, A. L. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109123251106 · Cited by 448
Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry
McClain, M. T., Heinlen, L. D., Dennis, G. J., Roebuck, J., Harley, J. B., & James, J. A. (2005) · Nature Medicine · doi:10.1038/nm1167 · Cited by 441
Cytotoxic mAb from rheumatic carditis recognizes heart valves and laminin
Galvin, J. E., Hemric, M. E., Ward, K., & Cunningham, M. W. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7132 · Cited by 248
Circulating heart-reactive antibodies in patients with myocarditis or cardiomyopathy
Neumann, D. A., Lynne Burek, C., Baughman, K. L., Rose, N. R., & Herskowitz, A. (1990) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(10)80331-6 · Cited by 191
Heart-specific autoantibodies induced by Coxsackievirus B3: Identification of heart autoantigens
Alvarez, F. L., Neu, N., Rose, N. R., Craig, S. W., & Beisel, K. W. (1987) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(87)90164-4 · Cited by 119
Metadata
- Authors
- Dale, J. B., & Beachey, E. H.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1985-08-01
- Volume
- 162
- Issue
- 2
- Pages
- 583-591
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2129645761
- Cited by
- 226
- References
- 0
- FWCI
- 19.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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