The DOI matches its Crossref record.
Enhancement of epidermal regeneration by biosynthetic epidermal growth factor.
Open accessAbstract
Epidermal regeneration depends on mitosis and migration of keratinocytes. Epidermal growth factor is known to stimulate growth of keratinocytes in vitro, thus it might be expected to promote wound healing. The results of this study show that topical application of biosynthetic human epidermal growth factor accelerates epidermal regeneration in split-thickness wounds and partial-thickness burns. The significant enhancement of epidermal regeneration suggests the potential for clinical use of epidermal growth factor for accelerating healing of burns, wounds from trauma, diabetic ulcers, skin graft donor sites, and others.
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Cited by
PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing
Barrientos, S., Stojadinovic, O., Golinko, M. S., Brem, H., & Tomic‐Canic, M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00410.x · Cited by 3,583
The pig as a model for human wound healing
Sullivan, T. P., Eaglstein, W. H., Davis, S. C., & Mertz, P. (2001) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2001.00066.x · Cited by 1,091
EGF and TGF‐α in wound healing and repair
Schultz, G., Clark, W., & Rotatori, D. S. (1991) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240450407 · Cited by 357
Self-citationMustoe, T. A., Pierce, G. F., Morishima, C., & Deuel, T. F. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115048 · Cited by 266
Metadata
- Authors
- Brown, G. L., Curtsinger, L., Brightwell, J. R., Ackerman, D. M., Tobin, G. R., Polk, H. C., George-Nascimento, C., Valenzuela, P., & Schultz, G. S.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1986-05-01
- Volume
- 163
- Issue
- 5
- Pages
- 1319-1324
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1877297661
- Cited by
- 299
- References
- 0
- FWCI
- 18.42
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Enhancement of epidermal regeneration by biosynthetic epidermal growth factor. https://app.cochat.ai/papers/10.1084/jem.163.5.1319
- The paper
- Brown, G. L., Curtsinger, L., Brightwell, J. R., Ackerman, D. M., Tobin, G. R., Polk, H. C., George-Nascimento, C., Valenzuela, P., & Schultz, G. S. (1986). Enhancement of epidermal regeneration by biosynthetic epidermal growth factor. The Journal of experimental medicine. https://doi.org/10.1084/jem.163.5.1319
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
