The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Interleukin 1 of the central nervous system is produced by ameboid microglia.
Open accessAbstract
By screening specific populations of rat brain cells, we found that ameboid microglia secrete an 18 kD peptide with IL-1 biological activity. The IL-1 activity released by microglia was found to be identical to rat macrophage IL-1 on fractionation by gel filtration and high pressure liquid anion-exchange chromatography, and it was neutralized by an antiserum specific for murine IL-1. When added to astroglia grown in culture, microglial IL-1 increased the cell number of five- to sevenfold, and increased astroglial incorporation of [3H]thymidine by three- to fivefold. We propose that the proliferation of astroglia in specific brain regions may be regulated by the signaled release of IL-1 from activated microglial cells.
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“IL-1β is another prominent pro-inflammatory cytokine that is produced primarily by activated microglia and macrophages (Giulian et al., 1986; Sairanen et al., 1997).”
From Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned (2014) · cites this paper as Giulian et al., 1986
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“Furthermore, intraventricular administration of IL-1β was sufficient to induce lipid peroxidation in adult rats, highlighting the causal relationship between inflammatory signaling and metabolic stress, the two major characteristics of aging (Giulian et al, 1986).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Giulian et al, 1986
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Cites
Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.
McCarthy, K. D., & de Vellis, J. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.85.3.890 · Cited by 3,845
Growth of a rat neuroblastoma cell line in serum-free supplemented medium.
Bottenstein, J. E., & SATO, G. H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.514 · Cited by 2,268
Dinarello, C. A. (1984) · Clinical Infectious Diseases · doi:10.1093/clinids/6.1.51 · Cited by 1,647
Characterization of ameboid microglia isolated from developing mammalian brain
Giulian, D., & Baker, T. J. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02163.1986 · Cited by 1,300
Self-citationInterleukin-1 Stimulation of Astroglial Proliferation After Brain Injury
Giulian, D., & Lachman, L. B. (1985) · Science · doi:10.1126/science.3872478 · Cited by 847
Self-citationCloning and expression of murine interleukin-1 cDNA in Escherichia coli
Lomedico, P. T., Gubler, U., Hellmann, C. P., Dukovich, M., Giri, J. G., Pan, Y. E., Collier, K. J., Semionow, R., Chua, A. O., & Mizel, S. B. (1984) · Nature · doi:10.1038/312458a0 · Cited by 816
RAFF, M. C., Fields, K. L., Hakomori, S., Mirsky, R., Pruss, R. M., & Winter, J. (1979) · Brain Research · doi:10.1016/0006-8993(79)90851-5 · Cited by 800
Fontana, A., Kristensen, F., Dubs, R., Gemsa, D., & Weber, E. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.6.2413 · Cited by 752
The functional relationship of the interleukins.
Smith, K. A., Lachman, L. B., Oppenheim, J. J., & Favata, M. F. (1980) · The Journal of Experimental Medicine · doi:10.1084/jem.151.6.1551 · Cited by 653
Self-citationDayer, J., Rochemonteix, B. G.-D., Burrus, B., Demczuk, S., & Dinarello, C. A. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112350 · Cited by 623
Cited by
Sorted by citations
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777
Treatment of Traumatic Brain Injury with Moderate Hypothermia
Marion, D. W., Penrod, L. E., Kelsey, S. F., Obrist, W. D., Kochanek, P. M., Palmer, A. M., Wisniewski, S. R., & DeKosky, S. T. (1997) · New England Journal of Medicine · doi:10.1056/nejm199702203360803 · Cited by 1,287
Microglia: Intrinsic immuneffector cell of the brain
Gehrmann, J., Matsumoto, Y., & Kreutzberg, G. W. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(94)00015-h · Cited by 1,111
Streit, W. J., Walter, S. A., & Pennell, N. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00069-0 · Cited by 1,096
Metadata
- Authors
- Giulian, D., Baker, T. J., Shih, L. C., & Lachman, L. B.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1986-08-01
- Volume
- 164
- Issue
- 2
- Pages
- 594-604
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2188228
- OpenAlex
- W2159746265
- Cited by
- 859
- References
- 33
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 10 · 2014: 12 · 2013: 10 · 2012: 14
- FWCI
- 21.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY04915)
- National Cancer Institute (CA 38043)
- National Institute of Neurological Disorders and Stroke (NS2311301)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- interleukin-1, ameboid microglia, microglial activation, astrocyte proliferation, neuroinflammation, rat brain
- MeSH terms
- Animals, Astrocytes, Brain, Cell Division, Cell Separation, Interleukin-1, Lymphocyte Activation, Nerve Growth Factors, Phagocytes, T-Lymphocytes, Rats
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