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Induction and detection of a human endothelial activation antigen in vivo.
Open accessAbstract
We used a murine mAb, H4/18, raised by immunization with IL-1-treated human umbilical vein endothelial cell cultures, to localize an endothelial activation antigen in induced human delayed hypersensitivity reactions (DHR) and in pathological tissues. We used streptococcus varidase to elicit DHR in human skin and we examined sequential skin biopsies with the immunoperoxidase technique. There was no staining for H4/18 binding antigen in normal endothelium of skin and other tissues; strong positive staining, localized to vascular endothelium, was seen at 16 and 23 h but disappeared by 6 d, when the DHR had faded. H4/18 binding antigen, also confined to endothelium, was detected in lymph nodes, skin, and other tissues exhibiting immune/inflammatory reactions. The studies indicate that H4/18 is a useful marker for activated endothelium in vivo and they support the relevance of in vitro studies on inducible endothelial cell functions.
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Citations
Cited by
Identification of an inducible endothelial-leukocyte adhesion molecule.
Bevilacqua, M. P., Pober, J. S., Mendrick, D. L., Cotran, R. S., & Gimbrone, M. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9238 · Cited by 1,609
Self-citationELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Le x
Phillips, M. L., Nudelman, E., Gaeta, F. C. A., Perez, M., Singhal, A. K., Hakomori, S.-I., & Paulson, J. C. (1990) · Science · doi:10.1126/science.1701274 · Cited by 1,306
Endothelial-Leukocyte Adhesion Molecules
Bevilacqua, M. P. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.004003 · Cited by 1,293
Self-citationJohnston, G. I., Cook, R. G., & McEver, R. P. (1989) · Cell · doi:10.1016/0092-8674(89)90636-3 · Cited by 786
Smith, C. W., Rothlein, R., Hughes, B. J., Mariscalco, M. M., Rudloff, H. E., Schmalstieg, F. C., & Anderson, D. C. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113788 · Cited by 599
Metadata
- Authors
- Cotran, R. S., Gimbrone, M. A., Bevilacqua, M. P., Mendrick, D. L., & Pober, J. S.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1986-08-01
- Volume
- 164
- Issue
- 2
- Pages
- 661-666
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2000069100
- Cited by
- 372
- References
- 0
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cotran, R. S., Gimbrone, M. A., Bevilacqua, M. P., Mendrick, D. L., & Pober, J. S. (1986). Induction and detection of a human endothelial activation antigen in vivo. The Journal of experimental medicine. https://doi.org/10.1084/jem.164.2.661
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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