The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Le x
Abstract
Recruitment of neutrophils to sites of inflammation is mediated in part by endothelial leukocyte adhesion molecule-1 (ELAM-1), which is expressed on activated endothelial cells of the blood vessel walls. ELAM-1 is a member of the LEC-CAM or selectin family of adhesion molecules that contain a lectin motif thought to recognize carbohydrate ligands. In this report, cell adhesion by ELAM-1 is shown to be mediated by a carbohydrate ligand, sialyl-Lewis X (SLe x ; NeuAcα2,3Galβ 1,4(Fucα1,3)-GlcNAc-), a terminal structure found on cell-surface glycoprotein and glycolipid carbohydrate groups of neutrophils.
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Citations
Cites
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Involvement of Sialic Acid on Endothelial Cells in Organ-Specific Lymphocyte Recirculation
Rosen, S. D., Singer, M. S., Yednock, T. A., & Stoolman, L. M. (1985) · Science · doi:10.1126/science.4001928 · Cited by 235
Cited by
Varki, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7390 · Cited by 946
Mechanisms That Regulate the Function of the Selectins and Their Ligands
VESTWEBER, D., & BLANKS, J. E. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.181 · Cited by 932
Protein Glycosylation in Cancer
Stowell, S. R., Ju, T., & Cummings, R. D. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040438 · Cited by 873
Springer, T. A., & Lasky, L. A. (1991) · Nature · doi:10.1038/349196a0 · Cited by 448
Ioffe, E., & Stanley, P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.728 · Cited by 400
Metadata
- Authors
- Phillips, M. L., Nudelman, E., Gaeta, F. C. A., Perez, M., Singhal, A. K., Hakomori, S.-I., & Paulson, J. C.
- Venue
- Science
- Published
- 1990-11-23
- Volume
- 250
- Issue
- 4984
- Pages
- 1130-1132
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2007181246
- Cited by
- 1,306
- References
- 2
- FWCI
- 26.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Phillips, M. L., Nudelman, E., Gaeta, F. C. A., Perez, M., Singhal, A. K., Hakomori, S.-I., & Paulson, J. C. (1990). ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Le x. Science. https://doi.org/10.1126/science.1701274
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
