The DOI matches its Crossref record.
Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells.
Open accessAbstract
Recent experiments (11-13) have shown that antigen-specific, CD8+, CD4- T lymphocytes can be induced to proliferate and become killer cells in the absence of a second population of "helper" CD8-, CD4+ cells. We have studied early events in the activation of CD4+ and CD8+ T cell subsets in the primary mixed leukocyte reaction. Dendritic cells are a major if not essential accessory cell for the activation of both subpopulations. Antigen-bearing macrophages fail to stimulate unprimed CD8+ cells, but act as targets for the sensitized cytolytic lymphocytes that are induced by dendritic cells. The initial proliferative response is comparable for CD4+ and CD8+ lymphocyte subsets. For both subpopulations, dendritic cells efficiently cluster the responding lymphocytes on the first day and induce the release of IL-2. The data indicate that CD4+ and CD8+ lymphocytes can be activated by a similar mechanism, and illustrate the special role of dendritic cells in the sensitization stage of cell-mediated immunity.
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Citations
Cited by
Valitutti, S., Müller, S., Dessing, M., & Lanzavecchia, A. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.4.1917 · Cited by 435
Duong, E., Fessenden, T. B., Lutz, E., Dinter, T., Yim, L., Blatt, S., Bhutkar, A., Wittrup, K. D., & Spranger, S. (2022) · Immunity · doi:10.1016/j.immuni.2021.10.020 · Cited by 372
Harding, F. A., & Allison, J. P. (1993) · The Journal of experimental medicine · doi:10.1084/jem.177.6.1791 · Cited by 265
Hayashi, T., Morimoto, C., Burks, J. S., Kerr, C., & Hauser, S. L. (1988) · Annals of Neurology · doi:10.1002/ana.410240408 · Cited by 100
Metadata
- Authors
- Inaba, K., Young, J. W., & Steinman, R. M.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1987-07-01
- Volume
- 166
- Issue
- 1
- Pages
- 182-194
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2083873864
- Cited by
- 240
- References
- 0
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Inaba, K., Young, J. W., & Steinman, R. M. (1987). Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.166.1.182
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