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Inhibition of cytokine production by cyclosporin A and transforming growth factor beta.
Open accessAbstract
We investigated the ability of cyclosporin A (CsA) and transforming growth factor beta (TGF-beta) to modulate the production of TNF-alpha and TNF-beta and IFN-gamma by unseparated, nonadherent, and adherent PBMC. Treatment of unseparated PBMC with CsA resulted in a significant dose-dependent inhibition of all three cytokines ranging from greater than 90% inhibition for IFN-gamma and TNF-beta, to approximately 70% for TNF-alpha. Pretreatment of unseparated or nonadherent PBMC with TGF-beta inhibited the production of IFN-gamma by 60-70%. However, the inhibition of TNF-alpha and TNF-beta production by these cells was only minimally affected, and at 0.1-1 ng/ml TGF-beta could enhance TNF-alpha production by unseparated PBMC. In contrast, pretreatment of adherent PBMC with TGF-beta inhibited the production of TNF-alpha by approximately 60%. TGF-beta also inhibited both TNF-alpha production and tumor cell cytotoxicity mediated by murine peritoneal-derived macrophages. These observations indicate that the biological effects of CsA and TGF-beta on immune functions are of a wider range than previously reported.
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Cited by
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985
Ranges, G. E., Figari, I. S., Espevik, T., & Palladino, M. A. (1987) · The Journal of experimental medicine · doi:10.1084/jem.166.4.991 · Cited by 494
Self-citationAcute Alcohol-Induced Liver Injury
Massey, V. L., & Arteel, G. E. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00193 · Cited by 147
Demidem, A., Taylor, J. R., Grammer, S. F., & Streilein, J. W. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12469761 · Cited by 50
NAGANUMA, H., SASAKI, A., SATOH, E., NAGASAKA, M., NAKANO, S., ISOE, S., TASAKA, K., & NUKUI, H. (1996) · Neurologia medico-chirurgica · doi:10.2176/nmc.36.789 · Cited by 42
Metadata
- Authors
- Espevik, T., Figari, I. S., Shalaby, M. R., Lackides, G. A., Lewis, G. D., Shepard, H. M., & Palladino, M. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1987-08-01
- Volume
- 166
- Issue
- 2
- Pages
- 571-576
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2067632818
- Cited by
- 447
- References
- 0
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Espevik, T., Figari, I. S., Shalaby, M. R., Lackides, G. A., Lewis, G. D., Shepard, H. M., & Palladino, M. A. (1987). Inhibition of cytokine production by cyclosporin A and transforming growth factor beta. The Journal of experimental medicine. https://doi.org/10.1084/jem.166.2.571
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