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Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells.
Open accessAbstract
Giant multinucleated cells (GMCs) are associated with granulomatous lesions that form in response to various infectious and noninfectious agents. The present study shows that mouse IL-4 induces the in vitro formation of GMCs by factor-dependent bone marrow and alveolar monocytes via cell fusion. GMCs appear 2 d after incubation of cell cultures with 20 U/ml or more of IL-4. Anti-IL-4 mAbs block the appearance of GMCs in these cultures, indicating that IL-4 acts directly on monocytes to promote fusion and does not secondarily induce the production of other soluble fusion factors. In soft agar cultures, IL-4 also causes the aggregation of macrophages and diminishes their migration. The role of IL-4 in a granulomatous inflammatory response is discussed.
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Cited by
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Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Mosley, B., Beckmann, M. P., March, C. J., Idzerda, R. L., Gimpel, S. D., VandenBos, T., Friend, D., Alpert, A., Anderson, D., Jackson, J., et al. (1989) · Cell · doi:10.1016/0092-8674(89)90295-x · Cited by 624
Modlin, R. L., Pirmez, C., Hofman, F. M., Torigian, V., Uyemura, K., Rea, T. H., Bloom, B. R., & Brenner, M. B. (1989) · Nature · doi:10.1038/339544a0 · Cited by 580
Alternative activation of macrophages: immune function and cellular biology
Varin, A., & Gordon, S. (2009) · Immunobiology · doi:10.1016/j.imbio.2008.11.009 · Cited by 361
Rankin, J. A., Picarella, D. E., Geba, G. P., Temann, U. A., Prasad, B., DiCosmo, B., Tarallo, A., Stripp, B., Whitsett, J., & Flavell, R. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7821 · Cited by 344
Metadata
- Authors
- McInnes, A., & Rennick, D. M.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1988-02-01
- Volume
- 167
- Issue
- 2
- Pages
- 598-611
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1978640748
- Cited by
- 305
- References
- 0
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- green
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- McInnes, A., & Rennick, D. M. (1988). Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.167.2.598
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