Alternative activation of macrophages: immune function and cellular biology

Varin, Audrey; Gordon, Siamon

doi:10.1016/j.imbio.2008.11.009

Cited by 361Immune cells in cancerPhagocytosis and Immune RegulationCardiac Fibrosis and Remodeling

Alternative activation of macrophages: immune function and cellular biology

Varin, Audrey, Gordon, Siamon·2009·Immunobiology

DOI 10.1016/j.imbio.2008.11.009

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Abstract

Macrophages are the first line of defense of the organism against pathogens and, in response to the microenvironment, become differentially activated. In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated. Alternative activated macrophages play an important role in the protection of the host by decreasing inflammation and promoting tissues repair. However, alternative activation of macrophages also downregulates host protection against selected pathogens. This defect is associated with an altered receptor expression pattern and extensive modulation of intracellular membrane trafficking. This review shows how alternative activation of macrophages induces extensive cellular remodelling of phagocytic, endocytic, signaling and secretory pathways which play an important, but unclear role in the pathogenesis of different disease.

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“In general, M1s or classically activated MΦs are pro-inflammatory and microbicidal, whereas M2s or alternatively activated MΦs are immunomodulatory, reparative, and poorly microbicidal [7–12].”
From Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds (2013) · cites this paper as [11]

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Alternative activation of macrophages: mechanism and functions
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Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration
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Graphene Oxide Induces Toll-like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages
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Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis
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Interactions between TGF-β1, canonical WNT/β-catenin pathway and PPAR γ in radiation-induced fibrosis
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Control of RSV-induced lung injury by alternatively activated macrophages is IL-4Rα-, TLR4-, and IFN-β-dependent
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Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-κB signaling pathway
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“As a part of the innate immune system, macrophages are relevant to defense against invading pathogens [18,19].”
Background
The innate and adaptive immune system of fish
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Generation of monocyte-derived tumor-associated macrophages using tumor-conditioned media provides a novel method to study tumor-associated macrophages in vitro
Benner, B. N., Scarberry, L., Suarez‐Kelly, L. P., Duggan, M. C., Campbell, A. R., Smith, E., Lapurga, G., Jiang, K., Butchar, J. P., Tridandapani, S., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0622-0 · Cited by 185 · see citing works
Modulation of macrophage activation and programming in immunity
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Viral infection of the lung: Host response and sequelae
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Microglia activation states and cannabinoid system: Therapeutic implications
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Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction
Foth, B. J., Tsai, I. J., Reid, A. J., Bancroft, A. J., Nichol, S., Tracey, A., Holroyd, N. E., Cotton, J. A., Stanley, E., Zarowiecki, M., et al. (2014) · Nature Genetics · doi:10.1038/ng.3010 · Cited by 152 · see citing works
Immunomodulatory activity of andrographolide on macrophage activation and specific antibody response
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The stimulation of an osteogenic response by classical monocyte activation
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Postprandial lipoproteins and the molecular regulation of vascular homeostasis
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Alternative activation of macrophages by IL-4 enhances the proteolytic capacity of their phagosomes through synergistic mechanisms
Balce, D. R., Li, B., Allan, E. R. O., Rybicka, J. M., Krohn, R. M., & Yates, R. M. (2011) · Blood · doi:10.1182/blood-2011-01-328906 · Cited by 131 · see citing works
MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis
Gharib, S. A., Johnston, L. K., Huizar, I., Birkland, T. P., Hanson, J. F., Wang, Y., Parks, W. C., & Manicone, A. M. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1112587 · Cited by 129 · see citing works
Macrophage immunoregulatory pathways in tuberculosis
Rajaram, M. V. S., Ni, B., Dodd, C. E., & Schlesinger, L. S. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.09.010 · Cited by 125 · see citing works
Targeting innate immunity for neurodegenerative disorders of the central nervous system
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Peptide-based materials for cancer immunotherapy
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Dendrimer mediated targeted delivery of sinomenine for the treatment of acute neuroinflammation in traumatic brain injury
Sharma, R. B., Kambhampati, S. P., Zhang, Z., Sharma, A., Chen, S., Duh, E. I., Kannan, S., Tso, M. O. M., & Kannan, R. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.036 · Cited by 126 · see citing works
Myeloid‐Derived Suppressor Cells Limit the Inflammation by Promoting T Lymphocyte Apoptosis in the Spinal Cord of a Murine Model of Multiple Sclerosis
Moliné-Velázquez, V., Cuervo, H., Sol, V. V., Ortega, M. C., Clemente, D., & de Castro, F. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00495.x · Cited by 124 · see citing works
M2 Polarized Macrophages and Giant Cells Contribute to Myofibrosis in Neuromuscular Sarcoidosis
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Proton-sensitive cation channels and ion exchangers in ischemic brain injury: New therapeutic targets for stroke?
Leng, T., Shi, Y., Xiong, Z., & Sun, D. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.12.008 · Cited by 121 · see citing works
Structure characteristics, hypoglycemic and immunomodulatory activities of pectic polysaccharides from Rosa setate x Rosa rugosa waste
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Use of In Vitro Assays to Assess Immunogenicity Risk of Antibody-Based Biotherapeutics
Joubert, M. K., Deshpande, M., Yang, J., Reynolds, H., Bryson, C. J., Fogg, M. H., Baker, M., Herskovitz, J., Goletz, T. J., Zhou, L., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159328 · Cited by 119 · see citing works
M2-polarized and tumor-associated macrophages alter NK cell phenotype and function in a contact-dependent manner
Krneta, T., Gillgrass, A. E., Poznanski, S. M., Chew, M. V., Lee, A. J., Kolb, M. R. J., & Ashkar, A. A. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a1215-552r · Cited by 116 · see citing works
Radiation-Induced Lung Fibrosis: Preclinical Animal Models and Therapeutic Strategies
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TSPO Modulates IL-4-Induced Microglia/Macrophage M2 Polarization via PPAR-γ Pathway
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Extraction of a Novel Cold-Water-Soluble Polysaccharide from Astragalus membranaceus and Its Antitumor and Immunological Activities
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Nuclear factor‐kappa‐B signaling in lung development and disease: One pathway, numerous functions
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The enhanced immune response of hepatitis B virus DNA vaccine using SiO2@LDH nanoparticles as an adjuvant
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CXCL4-induced plaque macrophages can be specifically identified by co-expression of MMP7 + S100A8 + in vitro and in vivo
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Cannabinoid Receptor 1 Participates in Liver Inflammation by Promoting M1 Macrophage Polarization via RhoA/NF-κB p65 and ERK1/2 Pathways, Respectively, in Mouse Liver Fibrogenesis
Tian, L., Li, W., Yang, L., Chang, N., Fan, X., Ji, X., Xie, J., Yang, L., & Li, L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01214 · Cited by 102 · see citing works
Effect of mannose targeting of hydroxyl PAMAM dendrimers on cellular and organ biodistribution in a neonatal brain injury model
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Self-citation
Alternative activation of macrophages: mechanism and functions
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Self-citation
Alternative activation of macrophages
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Self-citation

Authors: Varin, A., & Gordon, S.
Affiliations: University of Oxford (GB)
Corresponding author: Gordon, Siamon
ORCID: Varin, Audrey
Gordon, Siamon
Venue: Immunobiology
Publisher: Elsevier BV
Published: 2009-07
Volume: 214
Issue: 7
Pages: 630-641
ISSN: 0171-2985 (ISSN-L)
DOI: 10.1016/j.imbio.2008.11.009
OpenAlex: W2091360431
Cited by: 361
References: 112
Citations by year: 2026: 7 · 2025: 8 · 2024: 7 · 2023: 13 · 2022: 32 · 2021: 15 · 2020: 23 · 2019: 22 · 2018: 20 · 2017: 21 · 2016: 14 · 2015: 27 · 2014: 24 · 2013: 35 · 2012: 43
FWCI: 2.43
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Immunobiology (publishedVersion)
PubMed (publishedVersion)
Funders: Fondation pour la Recherche Médicale
Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: alternative macrophage activation, M2 macrophages, IL-4, IL-13, Th2 immune response, parasitic infection, allergy, inflammation, tissue repair, receptor expression, membrane trafficking, phagocytosis, endocytosis, secretory pathway, host-pathogen interaction
MeSH terms: Animals, Endocytosis, Humans, Hypersensitivity, Immune Tolerance, Macrophage Activation, Membrane Fusion, Parasitic Diseases, Wound Healing, Signal Transduction, Interleukin-4, Th2 Cells

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Alternative activation of macrophages: immune function and cellular biology

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