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Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen.
Open accessAbstract
IL-2 potentiates both growth and cytotoxic function of T lymphocytes and NK cells. Resting peripheral blood NK cells can respond directly to rIL-2, without requirement for accessory cells or cofactors, and enhanced cytotoxicity can be measured within a few hours after exposure to this lymphokine. In this study, we describe an activation antigen, Leu-23, that is rapidly induced and phosphorylated after IL-2 stimulation of NK cells and a subset of low buoyant density T lymphocytes. Previously, it has been uncertain whether all NK cells or only a subset are responsive to IL-2. Since within 18 h after exposure to IL-2, essentially all NK cells express Leu-23, these findings indicate that all peripheral blood NK cells are responsive to stimulation by IL-2. The Leu-23 antigen is a disulfide-bonded homodimer, composed of 24-kD protein subunits with two N-linked oligosaccharides. Appearance of this glycoprotein on NK cells is IL-2 dependent and closely parallels IL-2-induced cytotoxicity against NK-resistant solid tumor cell targets.
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Citations
Cited by
Biology of Natural Killer Cells
Trinchieri, G. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60664-1 · Cited by 2,902
The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells
Testi, R., D'Ambrosio, D., De Maria, R., & Santoni, A. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90193-7 · Cited by 451
LAIR-1, a Novel Inhibitory Receptor Expressed on Human Mononuclear Leukocytes
Meyaard, L., Adema, G. J., Chang, C., Woollatt, E., Sutherland, G. R., Lanier, L. L., & Phillips, J. H. (1997) · Immunity · doi:10.1016/s1074-7613(00)80530-0 · Cited by 401
Self-citationFlow-cytometric analysis of rare antigen-specific T cells
Bacher, P., & Scheffold, A. (2013) · Cytometry Part A · doi:10.1002/cyto.a.22317 · Cited by 155
Robinet, P., Baychelier, F., Fontaine, T., Picard, C., Debré, P., Vieillard, V., Latgé, J.-P., & Elbim, C. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303180 · Cited by 75
Metadata
- Authors
- Lanier, L. L., Buck, D. W., Rhodes, L., Ding, A., Evans, E., Barney, C., & Phillips, J. H.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1988-05-01
- Volume
- 167
- Issue
- 5
- Pages
- 1572-1585
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2006215283
- Cited by
- 245
- References
- 0
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lanier, L. L., Buck, D. W., Rhodes, L., Ding, A., Evans, E., Barney, C., & Phillips, J. H. (1988). Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen. The Journal of experimental medicine. https://doi.org/10.1084/jem.167.5.1572
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
