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Cited by 494

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule.

Open access
Lanier, L L, Testi, R, Bindl, J, Phillips, J H·1989·The Journal of experimental medicine

Abstract

Neural cell adhesion molecule (N-CAM) is a membrane glycoprotein expressed on neural and muscle tissues that is involved in homotypic adhesive interactions. We have demonstrated that N-CAM also is expressed on hematopoietic cells, and is recognized by the anti-Leu-19 mAb. Leu-19 is preferentially expressed on NK cells and T lymphocytes that mediate MHC-unrestricted cytotoxicity, but is also present on some myeloid leukemia cell lines. On NK cells, T cells, the KG1a.5 hematopoietic cell line, and a neuroblastoma cell line, Leu-19 is a approximately 140-kD polypeptide with N-linked carbohydrates and abundant sialic acid residues. Sequential immunoprecipitation and peptide mapping demonstrated that the Leu-19 and N-CAM molecules expressed on leukocyte and neuroblastoma cell lines are similar structures. These findings suggest that the Leu-19 antigen on leukocytes may be involved in cell adhesion, analogous to the function on N-CAM on neural cells.

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Metadata

Authors
Lanier, L. L., Testi, R., Bindl, J., & Phillips, J. H.
Venue
The Journal of experimental medicine
Published
1989-06-01
Volume
169
Issue
6
Pages
2233-2238
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
OpenAlex
W2164606734
Cited by
494
References
9
FWCI
12.90
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule. https://app.cochat.ai/papers/10.1084/jem.169.6.2233
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Lanier, L. L., Testi, R., Bindl, J., & Phillips, J. H. (1989). Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule. The Journal of experimental medicine. https://doi.org/10.1084/jem.169.6.2233

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.