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A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions.
Open accessAbstract
We have raised an mAb to a previously undescribed 135-kD externally disposed integral membrane protein that is enriched in the intercellular junctional domain of cultured human umbilical vein endothelial cells. This protein localizes at the appositional surfaces of cells as they become confluent and is stably expressed in the junctional zones of confluent monolayers. This protein is expressed in situ on continuous endothelia of all blood vessels in all human tissues examined. Moreover, this protein, as determined by mAb immunocytochemistry, is not expressed by any other cell type. This protein may mediate endothelial-specific functions restricted to the intercellular domain. It may also serve as a unique cell surface marker for the identification and purification of human endothelial cells.
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Cited by
Peng, H., Wright, V., Usas, A., Gearhart, B., Shen, H.-C., Cummins, J., & Huard, J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15153 · Cited by 733
A novel endothelial-specific membrane protein is a marker of cell-cell contacts.
Lampugnani, M. G., Resnati, M., Raiteri, M., Pigott, R., Pisacane, A., Houen, G., Ruco, L. P., & Dejana, E. (1992) · The Journal of cell biology · doi:10.1083/jcb.118.6.1511 · Cited by 632
An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
Johnson, L. A., Clasper, S., Holt, A. P., Lalor, P. F., Baban, D., & Jackson, D. G. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051759 · Cited by 346
Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis
Mamdouh, Z., Chen, X., Pierini, L. M., Maxfield, F. R., & Muller, W. A. (2003) · Nature · doi:10.1038/nature01300 · Cited by 317
Self-citationMonoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo.
Bogen, S., Pak, J., Garifallou, M., Deng, X., & Muller, W. A. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.3.1059 · Cited by 295
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Metadata
- Authors
- Muller, W. A., Ratti, C. M., McDonnell, S. L., & Cohn, Z. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1989-08-01
- Volume
- 170
- Issue
- 2
- Pages
- 399-414
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2055755227
- Cited by
- 358
- References
- 0
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Muller, W. A., Ratti, C. M., McDonnell, S. L., & Cohn, Z. A. (1989). A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions. The Journal of experimental medicine. https://doi.org/10.1084/jem.170.2.399
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
