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The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10.
Open accessAbstract
The human mannose-binding protein (MBP) plays a role in first line host defense against certain pathogens. It is an acute phase protein that exists in serum as a multimer of a 32-kD subunit. The NH2 terminus is rich in cysteines that mediate interchain disulphide bonds and stabilize the second collagen-like region. This is followed by a short intervening region, and the carbohydrate recognition domain is found in the COOH-terminal region. Analysis of the human MBP gene reveals that the coding region is interrupted by three introns, and all four exons appear to encode a distinct domain of the protein. It appears that the human MBP gene has evolved by recombination of an ancestral nonfibrillar collagen gene with a gene that encodes carbohydrate recognition, and is therefore similar to the human surfactant SP-A gene and the rat MBP gene. The gene for MBP is located on the long arm of chromosome 10 at 10q11.2-q21, a region that is included in the assignment for the gene for multiple endocrine neoplasia type 2A.
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Gilbert, W. (1978) · Nature · doi:10.1038/271501a0 · Cited by 2,300
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Identification and Characterization of a Novel Human Collectin CL-K1
Keshi, H., Sakamoto, T., Kawai, T., Ohtani, K., Katoh, T., Jang, S., Motomura, W., Yoshizaki, T., Fukuda, M., Koyama, S., et al. (2006) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2006.tb03868.x · Cited by 150
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Dahmer, M. K., Randolph, A., Vitali, S., & Quasney, M. W. (2005) · Pediatric Critical Care Medicine · doi:10.1097/01.pcc.0000161970.44470.c7 · Cited by 101
Metadata
- Authors
- Sastry, K., Herman, G. A., Day, L., Deignan, E., Bruns, G., Morton, C. C., & Ezekowitz, R. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1989-10-01
- Volume
- 170
- Issue
- 4
- Pages
- 1175-1189
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2031433110
- Cited by
- 274
- References
- 1
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10. https://app.cochat.ai/papers/10.1084/jem.170.4.1175
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- Sastry, K., Herman, G. A., Day, L., Deignan, E., Bruns, G., Morton, C. C., & Ezekowitz, R. A. (1989). The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10. The Journal of experimental medicine. https://doi.org/10.1084/jem.170.4.1175
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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