Genetic polymorphisms in sepsis

Dahmer, Mary K.; Randolph, Adrienne; Vitali, Sally; Quasney, Michael W.

doi:10.1097/01.pcc.0000161970.44470.c7

Cited by 101Sepsis Diagnosis and TreatmentInflammation biomarkers and pathwaysImmune Response and Inflammation

Genetic polymorphisms in sepsis

Dahmer, Mary K., Randolph, Adrienne, Vitali, Sally, Quasney, Michael W.·2005·Pediatric Critical Care Medicine

DOI 10.1097/01.pcc.0000161970.44470.c7

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Abstract

CONTEXT: Wide variability exists in the susceptibility to and outcome from sepsis even within similar intensive care unit populations. Some of this variability in the host may be due to genetic variation in genes coding for components of the innate immune response. OBJECTIVE: To review the evidence for a genetic influence on the susceptibility to and outcome from sepsis. DESIGN: Literature review. PATIENTS: Variety of adult and pediatric patients with various critical illnesses and infections. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Susceptibility to clinical symptoms of sepsis and outcome as measured by severity of disease and mortality. RESULTS: Polymorphisms in genes coding for proteins involved in the recognition of bacterial pathogens (Toll-like receptor 4, CD14, Fc(gamma)RIIa, and mannose-binding lectin) and the response to bacterial pathogens (tumor necrosis factor-alpha, interleukin (IL)-1alpha, IL-1beta, IL-1 receptor agonist, IL-6, IL-10, heat shock proteins, angiotensin I converting enzyme, plasminogen activator inhibitor-1) can influence the amount or function of the protein produced in response to bacterial stimuli. Evidence is discussed suggesting that some of these genetic polymorphisms influence the susceptibility to and outcome from sepsis. CONCLUSION: Host genetic variability in the regulatory and coding regions of genes for components of the innate immune system may influence the susceptibility to and/or outcome from sepsis. The disparate results observed in many studies of polymorphisms in sepsis emphasize the need for future studies to be larger, to include the analysis of multiple polymorphisms, and to be better designed with respect to control populations to identify the degree of influence that genetic variability has on sepsis.

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Additional factors such as CAR structure and design, disease burden, and host genomic background are likely to play a part in whether cytokine storm develops in patients treated with CAR T cells or blinatumomab.
“However, cytokine storm does not develop in all patients treated with CAR T cells or blinatumomab, so additional factors, such as CAR structure and design,51 disease burden,58 and host genomic background,59 are likely to play a part.”
From Cytokine storm (2020) · cites this paper as [59]

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Köenig, W., Khuseyinova, N., Hoffmann, M. M., März, W., Fröhlich, M., Hoffmeister, A., Brenner, H., & Rothenbacher, D. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01937-x · Cited by 75 · see citing works
Genetic variation in proinflammatory and anti-inflammatory cytokine production in multiple organ dysfunction syndrome*
Reid, C. L., Perrey, C., Pravica, V., Hutchinson, I. V., & Campbell, I. T. (2002) · Critical Care Medicine · doi:10.1097/00003246-200210000-00007 · Cited by 75 · see citing works
Is Interleukin-6 −174 Genotype Associated With the Development of Septicemia in Preterm Infants?
Harding, D., Dhamrait, S. S., Millar, A., Humphries, S. E., Marlow, N., Whitelaw, A., & Montgomery, H. (2003) · PEDIATRICS · doi:10.1542/peds.112.4.800 · Cited by 74 · see citing works
Polymorphism of IgG Fc Receptors in Meningococcal Disease
Fijen, C. A. P., Bredius, R. G. M., & Kuijper, E. J. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-7_part_1-199310010-00026 · Cited by 73 · see citing works
Tumor necrosis factor's effects on lung mechanics, gas exchange, and airway reactivity in sheep
Wheeler, A. P., Jesmok, G. J., & Brigham, K. L. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.68.6.2542 · Cited by 67 · see citing works
The common functional C(−159)T polymorphism within the promoter region of the lipopolysaccharide receptor CD14 is not associated with sepsis development or mortality
Hubacek, J. A., Stüber, F., Fröhlich, D., Book, M., Wetegrove, S., Rothe, G., & Schmitz, G. (2000) · Genes and Immunity · doi:10.1038/sj.gene.6363691 · Cited by 66 · see citing works
Association of tumor necrosis factor-2 allele with plasma tumor necrosis factor-alpha levels and mortality from septic shock
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Genetic polymorphism of human interleukin‐1α
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Meningococcal disease and polymorphism of FcγRIIa (CD32) in late complement component-deficient individuals
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Differences in N-linked glycosylation between human surfactant protein-B variants of the C or T allele at the single-nucleotide polymorphism at position 1580: implications for disease
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The –260 C→T promoter polymorphism of the lipopolysaccharide receptor CD14 and severe sepsis in trauma patients
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Induction of heat shock gene expression in colonic epithelial cells after incubation with Escherichia coli or endotoxin
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MASP1 (MBL-Associated Serine Protease 1)
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Phase I clinical trial of recombinant human tumor necrosis factor in children with refractory solid tumors: a Pediatric Oncology Group study.
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Types 1 and 2 plasminogen activator inhibitor and tumor necrosis factor alpha in patients with sepsis.
Páramo, J. A., Pérez, J. L., Serrano, M., & Rocha, E. A. V. (1990) · PubMed · Cited by 46 · see citing works
Alveolar Macrophages, Surfactant Lipids, and Surfactant Protein B Regulate the Induction of Immune Responses via the Airways
van Iwaarden, J. F., Claassen, E., Jeurissen, S. H. M., Haagsman, H. P., & Kraal, G. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.4.4239 · Cited by 43 · see citing works
Pilot Study Assessing TNF Gene Polymorphism as a Prognostic Marker for Disease Progression in Neonates with Sepsis
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TNF-α promoter, Nod2 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response to endotoxin
Schippers, E. F., Veer, C. V. ′., van Voorden, S., Martina, C. A. E., le Cessie, S., & van Dissel, J. T. (2004) · Cytokine · doi:10.1016/j.cyto.2003.12.003 · Cited by 41 · see citing works
Types 1 and 2 Plasminogen Activator lnhibitor and Tirmor Necrosis Factor Alpha in Fatients with Sepsis
Páramo, J. A., Pérez, J. L., Serrano, M., & Rochal, E. (1990) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1647143 · Cited by 39 · see citing works
Angiotensin II Receptor Blockade Inhibits Pneumocyte Apoptosis in Experimental Meconium Aspiration
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The TLR4 +896 polymorphism is not associated with lipopolysaccharide hypo-responsiveness in leukocytes
Imahara, S. D., Jelačić, S., Junker, C. E., & O’Keefe, G. E. (2004) · Genes and Immunity · doi:10.1038/sj.gene.6364147 · Cited by 32 · see citing works
Quantitation of human IgG subclass antibodies to Haemophilus influenzae type b capsular polysaccharide
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Extracellular H+ modulates acetylcholine-activated nonselective cation channels in guinea pig ileum
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Association between the A/A genotype at the lymphotoxin-α+250 site and increased mortality in children with positive blood cultures*
McArthur, J. A., Zhang, Q., & Quasney, M. W. (2002) · Pediatric Critical Care Medicine · doi:10.1097/00130478-200210000-00002 · Cited by 27 · see citing works
Self-citation
FcγRIIa and FcγRIIIb polymorphisms were not associated with meningococcal disease in Western Norway
SMITH, I., Vedeler, C. A., & Halstensen, A. I. (2003) · Epidemiology and Infection · doi:10.1017/s0950268802008087 · Cited by 24 · see citing works
The role of interleukin-10 in the pathogenesis of bacterial infection
van der Poll, T., Marchant, A., & van Deventer, S. J. H. (1997) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.1997.tb00465.x · Cited by 23 · see citing works
Intron 16 insertion of the angiotensin converting enzyme gene and transcriptional regulation
Rosatto, N. (1999) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/14.4.868 · Cited by 22 · see citing works
Role of Individual N-Linked Glycosylation Sites in the Function and Intracellular Transport of the Human α Folate Receptor
Roberts, S. J., Petropavlovskaja, M., Chung, K.-N., Knight, C. B., & Elwood, P. C. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0551 · Cited by 21 · see citing works
Association of an IL-1A 3′UTR polymorphism with end-stage renal disease and IL-1α expression
Bensen, J. T., Langefeld, C. D., Li, L., McCall, C. E., Cousart, S. L., Dryman, B. N., Freedman, B. I., & Bowden, D. W. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00856.x · Cited by 20 · see citing works
The cytokine synthesis by heterozygous carriers of the Toll-like receptor 4 Asp299Gly polymorphism does not differ from that of wild type homozygotes.
Heesen, M. A., Bloemeke, B., & Kunz, D. (2004) · PubMed · Cited by 20 · see citing works
Variable Number Tandem Repeat Polymorphism of the Interleukin‐1 Receptor Antagonist Gene in Meningococcal Disease
Carrol, E. D., Mobbs, K. J., Thomson, A. P. J., & Hart, C. A. (2002) · Clinical Infectious Diseases · doi:10.1086/341497 · Cited by 17 · see citing works
Regulation of Receptor‐Dependent Activation of the Innate Immune Response
Ulevitch, R. J. (2003) · The Journal of Infectious Diseases · doi:10.1086/374605 · Cited by 15 · see citing works
Pulmonary Surfactant Proteins A and D Recognize Lipid Ligands on Mycoplasma pneumoniae and Markedly Augment the Innate Immune Response to the Organism
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Expression of ACE mRNA in the human atrial myocardium is not dependent on left ventricular function, ACE inhibitor therapy, or the ACE I/D genotype
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Fc gamma receptor allotypes in children with bacterial meningitis. A preliminary study.
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A human monoclonal antibody recognizing a determinant shared by a group of HLA-B locus antigens associated with HLA-Bw6
Kosiński, S., Yang, S. Y., Ferrara, G. B., & H�mmerling, U. (1987) · Immunogenetics · doi:10.1007/bf00345466 · Cited by 2 · see citing works

Flagged first, then by citations

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Sorted by citations

Cytokine storm
Fajgenbaum, D. C., & June, C. H. (2020) · New England Journal of Medicine · doi:10.1056/nejmra2026131 · Cited by 3,196 · see citing works
Monitoring Immune Dysfunctions in the Septic Patient: A New Skin for the Old Ceremony
Monneret, G., Venet, F., Pachot, A., & Lepape, A. (2008) · Molecular Medicine · doi:10.2119/2007-00102.monneret · Cited by 340 · see citing works
Functional Consequences of Toll-like Receptor 4 Polymorphisms
Ferwerda, B., McCall, M. B. B., Verheijen, K., Kullberg, B. J., van der Ven, A. J. A. M., van der Meer, J. W. M., & Netea, M. G. (2008) · Molecular Medicine · doi:10.2119/2007-00135.ferwerda · Cited by 260 · see citing works
Pathophysiology and Treatment of Septic Shock in Neonates
Wynn, J. L., & Wong, H. R. (2010) · Clinics in Perinatology · doi:10.1016/j.clp.2010.04.002 · Cited by 260 · see citing works
The Host Response to Sepsis and Developmental Impact
Wynn, J. L., Cornell, T. T., Wong, H. R., Shanley, T. P., & Wheeler, D. S. (2010) · PEDIATRICS · doi:10.1542/peds.2009-3301 · Cited by 210 · see citing works
Immune dysfunction in cirrhosis
Sipeki, N. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i10.2564 · Cited by 163 · see citing works
Cytokine release syndrome in cancer immunotherapy with chimeric antigen receptor engineered T cells
Xu, X.-J., & Tang, Y.-M. (2014) · Cancer Letters · doi:10.1016/j.canlet.2013.10.004 · Cited by 156 · see citing works
Laminar inflammatory gene expression in the carbohydrate overload model of equine laminitis
Leise, B. S., Faleiros, R. R., Watts, M. R., Johnson, P. J., Black, S. J., & Belknap, J. K. (2010) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.2010.00122.x · Cited by 98 · see citing works
Cytokine Polymorphisms Have a Synergistic Effect on Severity of the Acute Sickness Response to Infection
Vollmer-Conna, U. S., Piraino, B., Cameron, B., Davenport, T. A., Hickie, I. B., Wakefield, D., Lloyd, A. R., & Dubbo Infection Outcomes Study Group (2008) · Clinical Infectious Diseases · doi:10.1086/592967 · Cited by 93 · see citing works
Genetics and genomics in pediatric septic shock
Wong, H. R. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e318246b546 · Cited by 85 · see citing works
Gene Expression Profiles of Immune Mediators and Histopathological Findings in Animal Models of Leptospirosis: Comparison between Susceptible Hamsters and Resistant Mice
Matsui, M., Rouleau, V., Bruyère-Ostells, L., & Goarant, C. (2011) · Infection and Immunity · doi:10.1128/iai.05727-11 · Cited by 79 · see citing works
Surfactant therapy for bronchiolitis in critically ill infants
Ventre, K. M., Haroon, M., & Davison, C. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005150.pub2 · Cited by 58 · see citing works
Retracted
Dangers, and benefits of the cytokine mediated response to injury and infection
Soeters, P. B., & Grimble, R. F. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.05.014 · Cited by 57 · see citing works
IRAK1 functional genetic variant affects severity of septic shock*
Toubiana, J., Courtine, E., Pène, F., Viallon, V., Asfar, P., Daubin, C., Rousseau, C., Chenot, C., Ouaaz, F., Grimaldi, D., et al. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181f9f9c7 · Cited by 57 · see citing works
Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients
Brenmoehl, J., Herfarth, H. H., Glück, T., Audebert, F., Barlage, S., Schmitz, G., Froehlich, D., Schreiber, S., Hampe, J., Schölmerich, J., et al. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0722-z · Cited by 56 · see citing works
Novel Pharmacologic Approaches to the Management of Sepsis: Targeting the Host Inflammatory Response
Wheeler, D. S., Zingarelli, B., Wheeler, W., & Wong, H. R. (2009) · Recent Patents on Inflammation & Allergy Drug Discovery · doi:10.2174/187221309788489779 · Cited by 56 · see citing works
Cardiopulmonary involvement in Puumala hantavirus infection
Rasmuson, J., Lindqvist, P., Sörensen, K., Hedström, M., Blomberg, A., & Ahlm, C. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-501 · Cited by 50 · see citing works
The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis
Davis, S. M., Clark, E., Nelson, L. T., & Silver, R. M. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.01.006 · Cited by 48 · see citing works
CD14 polymorphisms and serum CD14 levels through childhood: A role for gene methylation?
Munthe‐Kaas, M. C., Torjussen, T. M., Gervin, K., Carlsen, K. C. L., Carlsen, K. H., Granum, B. B., Hjorthaug, H. S., Undlien, D. E., & Lyle, R. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.02.010 · Cited by 47 · see citing works
Genetic Variation in the TNF Gene Is Associated with Susceptibility to Severe Sepsis, but Not with Mortality
Song, Z., Song, Y., Yin, J., Shen, Y., Yao, C., Sun, Z., Jiang, J., Zhu, D., Zhang, Y., Shen, Q., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046113 · Cited by 42 · see citing works
Association of tumor necrosis factor α −308G/A and interleukin-6 −174G/C gene polymorphism with pneumonia-induced sepsis
Feng, B., Mao, Z.-R., Pang, K., Zhang, S., & Li, L. (2015) · Journal of Critical Care · doi:10.1016/j.jcrc.2015.04.123 · Cited by 41 · see citing works
Sepsis in the Pediatric Cardiac Intensive Care Unit
Wheeler, D. S., Jeffries, H. E., Zimmerman, J. J., Wong, H. R., & Carcillo, J. A. (2011) · World Journal for Pediatric and Congenital Heart Surgery · doi:10.1177/2150135111403781 · Cited by 39 · see citing works
The Impact of Environmental and Genetic Factors on Neonatal Late-Onset Sepsis
Bizzarro, M. J., Jiang, Y., Hussain, N., Gruen, J. R., Bhandari, V., & Heping Zhang, D. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.07.060 · Cited by 39 · see citing works
Prevalence and Outcomes of Previously Healthy Adults Among Patients Hospitalized With Community-Onset Sepsis
Alrawashdeh, M., Klompas, M., Simpson, S. Q., Kadri, S. S., Poland, R., Guy, J. S., Perlin, J. B., & Rhee, C. (2022) · CHEST Journal · doi:10.1016/j.chest.2022.01.016 · Cited by 38 · see citing works
Association of IL-10 (-819T/C, -592A/C and -1082A/G) and IL-6 -174G/C gene polymorphism and the risk of pneumonia-induced sepsis
Mao, Z.-R., Zhang, S., & Feng, B. (2016) · Biomarkers · doi:10.1080/1354750x.2016.1210677 · Cited by 37 · see citing works
High-mobility group box-1 protein, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in children with community acquired infections and bacteraemia: a prospective study
Pavāre, J., Grope, I., Kalniņš, I., & Gardovska, D. (2010) · BMC Infectious Diseases · doi:10.1186/1471-2334-10-28 · Cited by 36 · see citing works
Glutamine Randomized Studies in Early Life: The Unsolved Riddle of Experimental and Clinical Studies
Briassouli, E., & Briassoulis, G. C. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/749189 · Cited by 33 · see citing works
Genetic Polymorphisms and the Risk of Infection Following Esophagectomy. Positive Association with TNF-α Gene −308 Genotype
Azim, K., McManus, R., Brophy, K., Ryan, A. M., Kelleher, D. P., & Reynolds, J. V. (2007) · Annals of Surgery · doi:10.1097/01.sla.0000259389.09161.49 · Cited by 33 · see citing works
Cytokine release syndrome
Yıldızhan, E., & Kaynar, L. (2018) · Journal of Oncological Sciences · doi:10.1016/j.jons.2018.09.002 · Cited by 35 · see citing works
Markers of acute inflammation in assessing and managing lower respiratory tract infections: focus on procalcitonin
Müller-Stich, B. P., & Prat, C. (2006) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2006.01654.x · Cited by 31 · see citing works
Genetic Variants in Genes of the Inflammatory Response in Association with Infective Endocarditis
Weinstock, M., Grimm, I., Dreier, J., Knabbe, C., & Vollmer, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110151 · Cited by 30 · see citing works
Ethanol suppresses phagosomal adhesion maturation, Rac activation, and subsequent actin polymerization during FcγR-mediated phagocytosis
Karavitis, J., Murdoch, E. L., Deburghgraeve, C. R., Ramírez, L., & Kovacs, E. J. (2012) · Cellular Immunology · doi:10.1016/j.cellimm.2012.02.002 · Cited by 29 · see citing works
Cytokine gene polymorphisms and risk for Upper Respiratory Symptoms in highly-trained athletes
Cox, A. J., Gleeson, M., Pyne, D. B., Callister, R., Fricker, P. A., & Scott, R. J. (2026) · PubMed · doi:10.22029/eir.2010.1648 · Cited by 25 · see citing works
Association of a common TLR-6 polymorphism with coronary artery disease – implications for healthy ageing?
Hamann, L., Koch, A. H., Sur, S., Hoefer, N., Glaeser, C., Schulz, S., Gross, M. C., Franke, A., Nöthlings, U., Zacharowski, K. D., et al. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-43 · Cited by 36 · see citing works
Genomic Variations and Susceptibility to Sepsis
Papathanassoglou, E. D. E., Giannakopoulou, M. D., & Bozas, E. (2006) · AACN Advanced Critical Care · doi:10.4037/15597768-2006-4006 · Cited by 22 · see citing works
Role of angiotensin‐converting enzyme gene polymorphisms in children with sepsis and septic shock
Çoğulu, Ö., Önay, H., Uzunkaya, D., Gündüz, C., Pehlıvan, S., Vardar, F., Atlıhan, F., Özkınay, C., & Özkınay, F. (2008) · Pediatrics International · doi:10.1111/j.1442-200x.2008.02583.x · Cited by 21 · see citing works
Innate immunity gene expression changes in critically ill patients with sepsis and disease-related malnutrition
Słotwiński, R., Sarnecka, A. K., Dąbrowska, A., Kosałka, K., Wachowska, E., Bałan, B. J., Jankowska, M., Korta, T., Niewiński, G., Kański, A., et al. (2015) · Central European Journal of Immunology · doi:10.5114/ceji.2015.54593 · Cited by 21 · see citing works
The lack of genetic association of the Toll-like receptor 2 (TLR2) Arg753Gln and Arg677Trp polymorphisms with rheumatic heart disease
Düzgün, N., Duman, T., Haydardedeoğlu, F. E., & Tutkak, H. (2006) · Clinical Rheumatology · doi:10.1007/s10067-006-0432-x · Cited by 21 · see citing works
A TREM-1 Polymorphism A/T within the Exon 2 Is Associated with Pneumonia in Burn-Injured Patients
Rivera-Chávez, F. A., Huebinger, R. M., Burris, A. M., Liu, M., Minei, J. P., Hunt, J. L., Arnoldo, B. D., & Barber, R. C. (2013) · ISRN Inflammation · doi:10.1155/2013/431739 · Cited by 20 · see citing works
Protective Effects of FCGR2A Polymorphism in Invasive Pneumococcal Diseases
Bouglé, A., Max, A., Mongardon, N., Grimaldi, D., Pène, F., Rousseau, C., Chiche, J., Bédos, J., Vicaut, É., & Mira, J. P. (2012) · CHEST Journal · doi:10.1378/chest.11-2516 · Cited by 20 · see citing works
Tumor necrosis factor-α −308G/A and −238G/A polymorphisms are associated with increased risks of sepsis: evidence from an updated meta-analysis
Zhang, M., Zhao, Y., & Liu, Q. (2017) · Apmis · doi:10.1111/apm.12661 · Cited by 20 · see citing works
Early Markers of Infection and Sepsis in Newborns and Children
Carcillo, J. A., Planquois, J., & Goldstein, B. (2006) · Cited by 19 · see citing works
Application of clinical proteomics in diagnosis and management of trauma patients
Alpantaki, K., Tsiridis, E. E., Pape, H., & Giannoudis, P. V. (2007) · Injury · doi:10.1016/j.injury.2006.11.021 · Cited by 18 · see citing works
Correlation of Fc-γ RIIA polymorphisms with latent Epstein–Barr virus infection and latent membrane protein 1 expression in patients with low grade B-cell lymphomas
Diamantopoulos, P. T., Kalotychou, V., Polonyfi, K., Sofotasiou, M., Anastasopoulou, A. N., Galanopoulos, A., Spanakis, N., Vassilakopoulos, T. P., Angelopoulou, M. K., Siakantaris, M. P., et al. (2012) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2012.762512 · Cited by 17 · see citing works
Association between lymphotoxin-α intron +252 polymorphism and sepsis: A meta-analysis
Tiancha, H., Huiqin, W., Jiyong, J., Jingfen, J., & Cui, W. (2011) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365548.2011.562528 · Cited by 17 · see citing works
Genetic variation in Fcγ receptor IIa and risk of coronary heart disease: negative results from two large independent populations
Karakas, M., Hoffmann, M. M., Vollmert, C., Rothenbacher, D., Meisinger, C., Winkelmann, B. R., Khuseyinova, N., Böhm, B. O., Illig, T., März, W., et al. (2009) · BMC Medical Genetics · doi:10.1186/1471-2350-10-46 · Cited by 17 · see citing works
Nigella sativa as a potential therapy for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats.
Bayır, Y., Albayrak, A., Can, I., Karagöz, Y., Cakir, A., Süleyman, H., Uyanık, H., Yayla, N., Polat, B., Karakuş, E., et al. (2012) · PubMed · Cited by 16 · see citing works
Guidelines for assessing immunocompetency in clinical trials for autoimmune diseases
Looney, R. J., Diamond, B., Holers, V. M., Levesque, M. C., Moreland, L. W., Nahm, M. H., & Clair, E. W. S. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.01.001 · Cited by 16 · see citing works
Neonatal Sepsis in the Very Low Birth Weight Preterm Infants: Part 1: Review of Patho-physiology
Haque, K. (2010) · doi:10.2174/1996327001003010001 · Cited by 23 · see citing works
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Authors: Dahmer, M. K., Randolph, A., Vitali, S., & Quasney, M. W.
Affiliations: University of Tennessee Health Science Center (US)
Harvard University (US)
ORCID: Dahmer, Mary K.
Randolph, Adrienne
Vitali, Sally
Quasney, Michael W.
Venue: Pediatric Critical Care Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-05
Volume: 6
Issue: Supplement
Pages: S61-S73
ISSN: 1529-7535 (ISSN-L)
DOI: 10.1097/01.pcc.0000161970.44470.c7
OpenAlex: W1978794637
Cited by: 101
References: 191
Citations by year: 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 6 · 2016: 2 · 2015: 2 · 2014: 10 · 2013: 6 · 2012: 10
FWCI: 1.25
Type: journal article
Language: en
Open access: closed
Locations: Pediatric Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: sepsis, genetic polymorphism, innate immunity, TLR4, CD14, FCGR2A, mannose-binding lectin, TNF-α, interleukins, heat shock proteins, angiotensin-converting enzyme, plasminogen activator inhibitor-1, sepsis susceptibility, sepsis mortality, host genetic variation
MeSH terms: Adult, Animals, Child, Humans, Immunity, Innate, Polymorphism, Genetic, Sepsis, Genetic Predisposition to Disease

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Genetic polymorphisms in sepsis

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