The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells.
Open accessAbstract
A metabolic pathway by which L-arginine (L-arg) is converted to the biologically active compound NO. has recently been described in macrophages (M phi) and endothelial cells. This report demonstrates that transferable products from activated Kupffer cells (KC) induce the conversion of large quantities of L-arg to nitrogen oxides within hepatocytes (HC). In M phi and endothelial cells, citrulline and NO2-/NO3- are the stable endproducts of this metabolic pathway. In contrast, HC L-arg metabolism resulted in significantly greater production of NO2-/NO3- than citrulline. The generation of NO. within HC was associated with a concurrent decrease in total protein synthesis.
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Citations
Cites
Stuehr, D. J., Gross, S. S., Sakuma, I., Levi, R., & Nathan, C. F. (1989) · The Journal of experimental medicine · doi:10.1084/jem.169.3.1011 · Cited by 457
Self-citation
Cited by
Nitric oxide as a secretory product of mammalian cells
Nathan, C. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.12.1381691 · Cited by 4,350
Role of nitric oxide synthesis in macrophage antimicrobial activity
Nathan, C. F., & Hibbs, J. B. (1991) · Current Opinion in Immunology · doi:10.1016/0952-7915(91)90079-g · Cited by 1,523
Mammalian nitric oxide synthases
Stuehr, D. J. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00016-x · Cited by 996
Self-citationInduction of nitric oxide synthase in asthma
Hamid, Q., Springall, D., Polak, J., Riveros-Moreno, V, Chanez, P., Bousquet, J., Godard, P., Holgate, S., Howarth, P., & Redington, A. (1993) · The Lancet · doi:10.1016/s0140-6736(05)80083-2 · Cited by 836
A novel neuronal messenger molecule in brain: The free radical, nitric oxide
Dawson, T. M., Dawson, V. L., & Snyder, S. H. (1992) · Annals of Neurology · doi:10.1002/ana.410320302 · Cited by 834
Metadata
- Authors
- Curran, R. D., Billiar, T. R., Stuehr, D. J., Hofmann, K., & Simmons, R. L.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1989-11-01
- Volume
- 170
- Issue
- 5
- Pages
- 1769-1774
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2024256058
- Cited by
- 399
- References
- 1
- FWCI
- 21.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Curran, R. D., Billiar, T. R., Stuehr, D. J., Hofmann, K., & Simmons, R. L. (1989). Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.170.5.1769
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
