The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production.
Open accessAbstract
Interleukin 4 (IL-4)-induced IgE production coincides with the appearance of the 2.2-kb productive epsilon-mRNA, but is preceded by synthesis of a 1.7-kb epsilon-RNA. Analysis of cDNA copies of the 5' end of this RNA indicated that the 1.7-kb epsilon-RNA is a germline epsilon immunoglobulin heavy chain transcript with an exon mapping 5' to the switch region. Transcription through switch regions has been implicated in the control of class switching. However, IL-4 or cloned CD4+ T cells were able to induce germline epsilon transcripts without inducing IgE synthesis, for which both signals were required. These results indicate that induction of human germline epsilon-RNA does not necessarily result in IgE synthesis, and that additional regulatory mechanisms are involved in class switching.
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Cites
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Cited by
Zurawski, G., & de Vries, J. E. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90021-3 · Cited by 872
Self-citationDefrance, T., Vanbervliet, B., Brière, F., Durand, I., Rousset, F., & Banchereau, J. (1992) · The Journal of experimental medicine · doi:10.1084/jem.175.3.671 · Cited by 638
Mechanism and Regulation of Immunoglobulin Isotype Switching
Coffman, R. L., Lebman, D. A., & Rothman, P. (1993) · Advances in Immunology · doi:10.1016/s0065-2776(08)60536-2 · Cited by 516
Self-citationJabara, H. H., Fu, S. M., Geha, R. S., & Vercelli, D. (1990) · The Journal of experimental medicine · doi:10.1084/jem.172.6.1861 · Cited by 444
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Metadata
- Authors
- Gauchat, J. F., Lebman, D. A., Coffman, R. L., Gascan, H., & de Vries, J. E.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1990-08-01
- Volume
- 172
- Issue
- 2
- Pages
- 463-473
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2053113974
- Cited by
- 349
- References
- 48
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Gauchat, J. F., Lebman, D. A., Coffman, R. L., Gascan, H., & de Vries, J. E. (1990). Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production. The Journal of experimental medicine. https://doi.org/10.1084/jem.172.2.463
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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