The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.
Open accessAbstract
A novel pathway of IgE-B cell differentiation has been identified. Engagement of the B cell antigen CD40 by F(ab')2 fragments of monoclonal antibody (mAb) 626.1 in the presence of recombinant interleukin 4 (rIL-4) induced intense IgE synthesis, but modest IgG synthesis, by highly purified human B cells. Surface IgE- B cells isolated by cell sorting were induced to produce IgE by mAb 626.1 and IL-4. Thus, IgE synthesis is unlikely to result from expansion of a B cell population precommitted to IgE in vivo. A neutralizing anti-IL-6 antibody strongly, but not completely, inhibited the IgE response. This indicates that autocrine production of IL-6 plays an important amplification role in IgE synthesis triggered by anti-CD40 mAb and IL-4. Although the exact role played by CD40 in IgE responses in vivo remains to be established, this T cell-independent system represents a useful model to characterize the biochemical and molecular events leading to IgE synthesis in human B cells.
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Cites
A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins
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Self-citationEndogenous interleukin 6 plays an obligatory role in interleukin 4‐dependent human IgE synthesis
Vercelli, D., Jabara, H. H., Arai, K., Yokota, T., & Geha, R. S. (1989) · European Journal of Immunology · doi:10.1002/eji.1830190811 · Cited by 213
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Cited by
Molecular mechanism and function of CD40/CD40L engagement in the immune system
Elgueta, R., Benson, M. J., De Vries, V. C., Wasiuk, A., Guo, Y., & Noelle, R. J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00782.x · Cited by 1,625
Activation of human dendritic cells through CD40 cross-linking.
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Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
Rousset, F., Garcia, E., Defrance, T., Péronne, C., Vezzio, N., Hsu, D. H., Kastelein, R., Moore, K. W., & Banchereau, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1890 · Cited by 1,238
Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM
Korthäuer, U., Graf, D., Mages, H. W., Brière, F., Padayachee, M., Malcolm, S., Ugazio, A. G., Notarangelo, L. D., Levinsky, R. J., & Kroczek, R. A. (1993) · Nature · doi:10.1038/361539a0 · Cited by 721
Induction of human IgE synthesis in B cells by mast cells and basophils
Gauchat, J.-F., Henchoz, S., Mazzei, G., Aubry, J.-P., Brunner, T., Blasey, H., Life, P., Talabot, D., Flores-Romo, L., Thompson, J., et al. (1993) · Nature · doi:10.1038/365340a0 · Cited by 656
Metadata
- Authors
- Jabara, H. H., Fu, S. M., Geha, R. S., & Vercelli, D.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1990-12-01
- Volume
- 172
- Issue
- 6
- Pages
- 1861-1864
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1989055057
- Cited by
- 444
- References
- 14
- FWCI
- 11.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. https://app.cochat.ai/papers/10.1084/jem.172.6.1861
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- Jabara, H. H., Fu, S. M., Geha, R. S., & Vercelli, D. (1990). CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.172.6.1861
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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