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Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action.
Open accessAbstract
Transforming growth factor beta (TGF-beta) acts as a potent inhibitor of the growth and functions of lymphoid and hemopoietic progenitor cells. Cell proliferation depends not only on the presence of growth factors, but also on the development of specific receptor-signal transducing complexes. We therefore investigated whether the inhibitory actions of TGF-beta could be mediated by inhibition of growth factor receptors. TGF-beta inhibited the constitutive level of interleukin 1 receptor (IL-1R) expression on several murine lymphoid and myeloid progenitor cell lines, as well as IL-1R expression induced by interleukin 3 (IL-3) on normal murine and human bone marrow cells. Furthermore, treatment of bone marrow progenitor cells with TGF-beta concomitantly inhibited the ability of IL-1 to promote high proliferative potential (HPP) colony formation as well as blocked IL-1-induced IL-2 production by EL-4 6.1 cells. These findings provide the first evidence that the inhibitory action of TGF-beta on the growth and functional activities of hematopoietic and T cells is associated with a reduction in the cell surface receptor expression for IL-1.
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Citations
Cited by
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Seita, J., & Weissman, I. L. (2010) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.86 · Cited by 932
Miller, A., Lider, O., Roberts, A. B., Sporn, M. B., & Weiner, H. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.421 · Cited by 732
Transforming Growth Factor-β1 to the Bone
Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0001 · Cited by 710
Anergic T Cells as Suppressor Cells in Vitro
Lombardi, G., Sidhu, S., Batchelor, R., & Lechler, R. (1994) · Science · doi:10.1126/science.8202711 · Cited by 366
Signaling pathways governing stem-cell fate
Blank, U., Karlsson, G., & Karlsson, S. (2008) · Blood · doi:10.1182/blood-2007-07-075168 · Cited by 355
Metadata
- Authors
- Dubois, C. M., Ruscetti, F. W., Palaszynski, E. W., Falk, L. A., Oppenheim, J. J., & Keller, J. R.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1990-09-01
- Volume
- 172
- Issue
- 3
- Pages
- 737-744
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2027656179
- Cited by
- 225
- References
- 0
- FWCI
- 10.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action. https://app.cochat.ai/papers/10.1084/jem.172.3.737
- The paper
- Dubois, C. M., Ruscetti, F. W., Palaszynski, E. W., Falk, L. A., Oppenheim, J. J., & Keller, J. R. (1990). Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action. The Journal of experimental medicine. https://doi.org/10.1084/jem.172.3.737
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
