The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
Signaling pathways governing stem-cell fate
Open accessAbstract
Hematopoietic stem cells (HSCs) are historically the most thoroughly characterized type of adult stem cell, and the hematopoietic system has served as a principal model structure of stem-cell biology for several decades. However, paradoxically, although HSCs can be defined by function and even purified to near-homogeneity, the intricate molecular machinery and the signaling mechanisms regulating fate events, such as self-renewal and differentiation, have remained elusive. Recently, several developmentally conserved signaling pathways have emerged as important control devices of HSC fate, including Notch, Wingless-type (Wnt), Sonic hedgehog (Shh), and Smad pathways. HSCs reside in a complex environment in the bone marrow, providing a niche that optimally balances signals that control self-renewal and differentiation. These signaling circuits provide a valuable structure for our understanding of how HSC regulation occurs, concomitantly with providing information of how the bone marrow microenvironment couples and integrates extrinsic with intrinsic HSC fate determinants. It is the focus of this review to highlight some of the most recent developments concerning signaling pathways governing HSC fate.
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Cites
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WNT signalling in the immune system: WNT is spreading its wings
Staal, F. J. T., Luis, T. C., & Tiemessen, M. M. (2008) · Nature Reviews Immunology · doi:10.1038/nri2360 · Cited by 582
Neurogenesis in the embryonic and adult brain: same regulators, different roles
Urbán, N., & Guillemot, F. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00396 · Cited by 493
The replication rate of human hematopoietic stem cells in vivo
Catlin, S. N., Busque, L., Gale, R. E., Guttorp, P., & Abkowitz, J. L. (2011) · Blood · doi:10.1182/blood-2010-08-303537 · Cited by 259
Grigoriadis, A. E., Kennedy, M., Bozec, A., Brunton, F., Stenbeck, G., Park, I.-H., Wagner, E. F., & Keller, G. M. (2010) · Blood · doi:10.1182/blood-2009-07-234690 · Cited by 151
Rodriguez, S., Chora, A., Goumnerov, B., Mumaw, C., Goebel, W. S., Fernandez, L., Baydoun, H., HogenEsch, H., Dombkowski, D. M., Karlewicz, C. A., et al. (2009) · Blood · doi:10.1182/blood-2009-04-214916 · Cited by 135
Metadata
- Authors
- Blank, U., Karlsson, G., & Karlsson, S.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-01-15
- Volume
- 111
- Issue
- 2
- Pages
- 492-503
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2100721053
- Cited by
- 355
- References
- 144
- FWCI
- 15.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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