The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis.
Open accessAbstract
We have examined previously the peptide specificity of the T cell response to myelin basic protein (MBP) in patients with multiple sclerosis (MS) and healthy controls, and demonstrated that an epitope spanning amino acids 87-106 was frequently recognized. Because this region is encephalitogenic in some experimental animals, it has been postulated that the response to the epitope may have relevance to MS. In this study, the fine specificity of this response is studied using four well-characterized, monospecific T cell lines from three MS patients and an identical twin of a patient. Each of the lines recognized a peptide with the same core sequence, amino acids 89-99, although the responses were affected to various degrees by truncations at the COOH- or NH2 terminal ends of the 87-106 epitope. Importantly, the epitope was recognized in conjunction with four different HLA-DR molecules. Also, the T cell receptor beta chain usage was heterogeneous, and each line expressed a different VDJ sequence. The four HLA-DR molecules restricting the response to this epitope have been shown to be overrepresented in MS populations in various geographic areas, suggesting that the response to this region of the MBP molecule may be relevant to the pathogenesis of MS. These findings may have important implications in designing therapeutic strategies for the disease.
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1 retracted
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Cited by
Immunology of multiple sclerosis
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Self-citationMHC ligands and peptide motifs: first listing
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Several Common HLA-DR Types Share Largely Overlapping Peptide Binding Repertoires
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Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein
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Self-citation
Metadata
- Authors
- Martin, R., Howell, M. D., Jaraquemada, D., Flerlage, M., Richert, J., Brostoff, S., Long, E. O., McFarlin, D. E., & McFarland, H. F.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1991-01-01
- Volume
- 173
- Issue
- 1
- Pages
- 19-24
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2117777657
- Cited by
- 287
- References
- 20
- FWCI
- 27.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis. https://app.cochat.ai/papers/10.1084/jem.173.1.19
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- Martin, R., Howell, M. D., Jaraquemada, D., Flerlage, M., Richert, J., Brostoff, S., Long, E. O., McFarlin, D. E., & McFarland, H. F. (1991). A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis. The Journal of experimental medicine. https://doi.org/10.1084/jem.173.1.19
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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