The DOI matches its Crossref record.
Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides
Abstract
Experimental allergic encephalomyelitis (EAE) is an autoimmune disease of the central nervous system mediated by CD4 + T cells reactive with myelin basic protein (MBP). Rats were rendered resistant to the induction of EAE by vaccination with synthetic peptides corresponding to idiotypic determinants of the β chain VDJ region and Jα regions of the T cell receptor (TCR) that are conserved among encephalitogenic T cells. These findings demonstrate the utility of TCR peptide vaccination for modulating the activity of autoreactive T cells and represent a general therapeutic approach for T cell-mediated pathogenesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
The immunologic basis for the treatment of psoriasis with new biologic agents
Krueger, J. G. (2002) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2002.120568 · Cited by 600
Shared Human T Cell Receptor V β Usage to Immunodominant Regions of Myelin Basic Protein
Wucherpfennig, K. W., Ota, K., Endo, N., Seidman, J. G., Rosenzweig, A., Weiner, H. L., & Hafler, D. A. (1990) · Science · doi:10.1126/science.1693015 · Cited by 386
Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis
Martin, R., McFarland, H. F., & Boggs, J. M. (1995) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369509084683 · Cited by 376
Martin, R., Jaraquemada, D., Flerlage, M., Richert, J., Whitaker, J., Long, E. O., McFarlin, D. E., & McFarland, H. F. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.2.540 · Cited by 342
Wekerle, H., Kojima, K., Lannes-Vieira, J., Lassmann, H., & Linington, C. (1994) · Annals of Neurology · doi:10.1002/ana.410360714 · Cited by 292
Metadata
- Authors
- Howell, M. D., Winters, S. T., Olee, T., Powell, H. C., Carlo, D. J., & Brostoff, S. W.
- Venue
- Science
- Published
- 1989-11-03
- Volume
- 246
- Issue
- 4930
- Pages
- 668-670
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2045757279
- Cited by
- 407
- References
- 0
- FWCI
- 43.49
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides. https://app.cochat.ai/papers/10.1126/science.2814489
- The paper
- Howell, M. D., Winters, S. T., Olee, T., Powell, H. C., Carlo, D. J., & Brostoff, S. W. (1989). Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides. Science. https://doi.org/10.1126/science.2814489
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
