The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways.
Open accessAbstract
Presentation of antigen in the form of immune complexes to B lymphocytes by follicular dendritic cells (FDC) is considered to be a central step in the generation of memory B cells. During this process, which takes place in the microenvironment of the germinal center, B cells and FDC are in close physical contact. In the present study, we have explored the molecular basis of FDC-B cell interaction by using FDC and B cells derived from human tonsils. We found that FDC express high levels of the adhesion receptors intercellular adhesion molecule 1 (ICAM-1 [CD54]) and vascular cell adhesion molecule 1 (VCAM-1), while the B lymphocytes express lymphocyte function-associated antigen 1 (LFA-1 [CD11a/18]), very late antigen 4 (VLA-4 [CD49d], and CD44. Furthermore, we established that both the LFA-1/ICAM-1 and VLA-4/VCAM-1 adhesion pathways are involved in FDC-B lymphocyte binding, and therefore, these pathways might be essential in affinity selection of B cells and in the formation of B memory cells.
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Cites
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Cited by
Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5
Allen, C. D. C., Ansel, K. M., Low, C., Lesley, R., Tamamura, H., Fujii, N., & Cyster, J. G. (2004) · Nature Immunology · doi:10.1038/ni1100 · Cited by 802
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de Gorter, D. J. J., Beuling, E. A., Kersseboom, R., Middendorp, S., van Gils, J. M., Hendriks, R. W., Pals, S. T., & Spaargaren, M. (2007) · Immunity · doi:10.1016/j.immuni.2006.11.012 · Cited by 285
Self-citationArana, E., Vehlow, A., Harwood, N. E., Vigorito, E., Henderson, R., Turner, M., Tybulewicz, V. L. J., & Batista, F. D. (2008) · Immunity · doi:10.1016/j.immuni.2007.12.003 · Cited by 156
Liu, B., & Li, Z. (2008) · Blood · doi:10.1182/blood-2008-03-143107 · Cited by 129
Metadata
- Authors
- Koopman, G., Parmentier, H. K., Schuurman, H. J., Newman, W., Meijer, C. J., & Pals, S. T.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1991-06-01
- Volume
- 173
- Issue
- 6
- Pages
- 1297-1304
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1988626998
- Cited by
- 290
- References
- 45
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways. https://app.cochat.ai/papers/10.1084/jem.173.6.1297
- The paper
- Koopman, G., Parmentier, H. K., Schuurman, H. J., Newman, W., Meijer, C. J., & Pals, S. T. (1991). Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways. The Journal of experimental medicine. https://doi.org/10.1084/jem.173.6.1297
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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