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Cited by 279

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Selection of a human T helper type 1-like T cell subset by mycobacteria.

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Haanen, J B, de Waal Malefijt, R, Res, P C, Kraakman, E M, Ottenhoff, T H, de Vries, R R, Spits, H·1991·The Journal of experimental medicine
DOI 10.1084/jem.174.3.583
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Abstract

Mycobacteria elicit a cellular immune response in their hosts. This response usually leads to protective immunity, but may sometimes be accompanied by immunopathology due to delayed type hypersensitivity (DTH). A striking example in man is tuberculoid leprosy, which is characterized by high cellular immunity to Mycobacterium leprae and immunopathology due to DTH. Skin lesions of patients suffering from this disease have the characteristics of DTH reactions in which macrophages and CD4+ T lymphocytes predominate. In animal models, it has been shown that DTH responses are associated with the presence of a particular subset of CD4+ T cells (T helper type 1 [Th1]) that secrete only certain cytokines, such as interleukin 2 (IL-2), interferon gamma (IFN-gamma), and lymphotoxin, but no IL-4 or IL-5. We studied the cytokine release of activated M. leprae-reactive CD4+ T cell clones derived from tuberculoid leprosy patients. These T cell clones, which were reactive with mycobacterial heat shock proteins, exhibited a Th1-like cytokine secretion pattern with very high levels of IFN-gamma. Half of these clones secreted low levels of IL-4 and IL-5, but the ratio of IFN-gamma to IL-4 and IL-5 was much higher than that of T cell clones reactive with nonmycobacterial antigens. A Th1-like cytokine secretion pattern was also observed for T cell clones and polyclonal T cell lines from control individuals that recognized both heat shock and other mycobacterial antigens. The levels of IFN-gamma secreted by these clones were, however, significantly less than those of patient-derived T cell clones. This Th1-like pattern was not found with T cell clones from the same patients and healthy individuals generated in the same manner, but reactive with nonmycobacterial antigens. Our data thus indicate that mycobacteria selectively induce human T cells with a Th1-like cytokine secretion profile.

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Metadata

Authors
Haanen, J. B., de Waal Malefijt, R., Res, P. C., Kraakman, E. M., Ottenhoff, T. H., de Vries, R. R., & Spits, H.
Venue
The Journal of experimental medicine
Publisher
Rockefeller University Press
Published
1991-09-01
Volume
174
Issue
3
Pages
583-592
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.174.3.583
OpenAlex
W2076171364
Cited by
279
References
23
FWCI
29.53
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Selection of a human T helper type 1-like T cell subset by mycobacteria. https://app.cochat.ai/papers/10.1084/jem.174.3.583
The paper
Haanen, J. B., de Waal Malefijt, R., Res, P. C., Kraakman, E. M., Ottenhoff, T. H., de Vries, R. R., & Spits, H. (1991). Selection of a human T helper type 1-like T cell subset by mycobacteria. The Journal of experimental medicine. https://doi.org/10.1084/jem.174.3.583

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.