TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,438 · see citing works

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

Snapper, C. M., & Paul, W. E. (1987) · Science · doi:10.1126/science.3107127 · Cited by 1,927 · see citing works

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies

Cherwinski, H., Schumacher, J., Brown, K., & Mosmann, T. (1987) · Journal of Experimental Medicine · doi:10.1084/jem.166.5.1229 · Cited by 1,118 · see citing works

Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

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Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

Cher, D., & Mosmann, T. R. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.11.3688 · Cited by 960 · see citing works

Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells

Stevens, T. L., Bossie, A., Sanders, V. M., Fernandez-Botran, R., Coffman, R. L., Mosmann, T. R., & Vitetta, E. S. (1988) · Nature · doi:10.1038/334255a0 · Cited by 933 · see citing works

The isolation and characterization of the human suppressor inducer T cell subset.

Morimoto, C., Letvin, N. L., Distaso, J. A., Aldrich, W. R., & Schlossman, S. F. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.3.1508 · Cited by 848 · see citing works

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

Gajewski, T. F., & Fitch, F. W. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.12.4245 · Cited by 839 · see citing works

Two types of mouse helper T-cell clone Implications for immune regulation.

Mosmann, T., & Coffman, R. (1987) · Immunology today (Amsterdam. Regular ed.) · doi:10.1016/0167-5699(87)90171-x · Cited by 826 · see citing works

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

Coffman, R. L., Ohara, J., Bond, M. W., Carty, J., Zlotnik, A., & Paul, W. E. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.12.4538 · Cited by 796 · see citing works

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

Coffman, R. L., Seymour, B. W. P., Lebman, D. A., Hiraki, D. D., Christiansen, J. A., Shrader, B., Cherwinski, H. M., Savelkoul, H. F. J., Finkelman, F. D., Bond, M. W., et al. (1988) · Immunological Reviews · doi:10.1111/j.1600-065x.1988.tb00739.x · Cited by 755 · see citing works

A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

Coffman, R. L., & Carty, J. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.3.949 · Cited by 753 · see citing works

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

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IFN- gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.

Finkelman, F. D., Katona, I. M., Mosmann, T. R., & Coffman, R. L. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.4.1022 · Cited by 724 · see citing works

The isolation and characterization of the human helper inducer T cell subset.

Morimoto, C., Letvin, N. L., Boyd, A., Hagan, M., Brown, H. M., Kornacki, M. M., & Schlossman, S. F. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.6.3762 · Cited by 692 · see citing works

CELL TO CELL INTERACTION IN THE IMMUNE RESPONSE

Mitchell, G. F., & MILLER, J. F. A. P. (1968) · The Journal of Experimental Medicine · doi:10.1084/jem.128.4.821 · Cited by 671 · see citing works

IL-4 is required to generate and sustain in vivo IgE responses.

Finkelman, F. D., Katona, I. M., Urban, J. F., Holmes, J. M., Ohara, J., Tung, A. S., Sample, J. V., & Paul, W. E. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.7.2335 · Cited by 668 · see citing works

Thymus-Marrow Cell Combinations. Synergism in Antibody Production.

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Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing.

Pace, J. L., Russell, S. W., Torres, B. A., Johnson, H. M., & Gray, P. W. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.130.5.2011 · Cited by 441 · see citing works

IgG2a restriction of murine antibodies elicited by viral infections.

Coutelier, J. P., van der Logt, J. T. M., Heessen, F. W. A., Warnier, G., & Snick, J. V. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.165.1.64 · Cited by 428 · see citing works

Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1.

Vitetta, E. S., Ohara, J., Myers, C. D., Layton, J. E., Krammer, P. H., & Paul, W. E. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.162.5.1726 · Cited by 411 · see citing works

Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells.

Fernandez-Botrán, R., Sanders, V. M., Mosmann, T. R., & Vitetta, E. S. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.2.543 · Cited by 379 · see citing works

T-cell and mast cell lines respond to B-cell stimulatory factor 1.

Mosmann, T. R., Bond, M. W., Coffman, R. L., Ohara, J., & Paul, W. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.15.5654 · Cited by 378 · see citing works

Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures.

Lebman, D. A., & Coffman, R. L. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.3.853 · Cited by 370 · see citing works

Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma.

Murray, H. W., Spitalny, G. L., & Nathan, C. F. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.3.1619 · Cited by 355 · see citing works

Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.

Finkelman, F. D., Katona, I. M., Urban, J. F., Snapper, C. M., Ohara, J., & Paul, W. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9675 · Cited by 349 · see citing works

Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.

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CD4+ T Cells: Specificity and Function

Janeway, C. A., Carding, S. R., Jones, B., et al. (1988) · Immunological Reviews · doi:10.1111/j.1600-065x.1988.tb00732.x · Cited by 273 · see citing works

The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent.

Schumacher, J. H., O’Garra, A., Shrader, B., Kimmenade, A. V., Bond, M. W., Mosmann, T. R., & Coffman, R. L. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.5.1576 · Cited by 260 · see citing works

‘B-cell factors’ are pleiotropic

O’Garra, A., Umland, S. P., France, T., et al. (1988) · Immunology Today · doi:10.1016/0167-5699(88)91259-5 · Cited by 230 · see citing works

The Relationship Between Humoral and Cell‐Mediated Immunity

Parish, C. R. (1972) · Immunological Reviews · doi:10.1111/j.1600-065x.1972.tb00059.x · Cited by 227 · see citing works

Murine cutaneous leishmaniasis : Susceptibility correlates with differential expansion of helper T-cell subsets

Locksley, R. M., Heinzel, F. P., Sadick, M. D., et al. (1987) · Annales de l Institut Pasteur Immunologie · doi:10.1016/s0769-2625(87)80030-2 · Cited by 215 · see citing works

T cells that help B cell responses to soluble antigen are distinguishable from those producing interleukin 2 on mitogenic or allogeneic stimulation.

Arthur, R. P., & Mason, D. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.163.4.774 · Cited by 214 · see citing works

Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells.

Killar, L. M., MacDonald, G., West, J., Woods, A., & Bottomly, K. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.6.1674 · Cited by 207 · see citing works

Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression.

Vadas, M. A., Miller, J. F. A. P., McKenzie, I. F. C., et al. (1976) · The Journal of Experimental Medicine · doi:10.1084/jem.144.1.10 · Cited by 207 · see citing works

Profiles of lymphokine activities and helper function for IgE in human T cell clones

Maggi, E., Prete, G. D., Macchia, D., Parronchi, P., Tiri, A., Chrétien, I., Ricci, M., & Romagnani, S. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180712 · Cited by 199 · see citing works

The synergistic anti-proliferative effect of gamma-interferon and human lymphotoxin.

Lee, S. H., Aggarwal, B. B., Rinderknecht, E., et al. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.3.1083 · Cited by 193 · see citing works

Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes.

Boom, W. H., Liano, D., & Abbas, A. K. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.4.1350 · Cited by 191 · see citing works

The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice.

Kurt‐Jones, E. A., Liano, D., HayGlass, K. T., et al. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.11.3773 · Cited by 191 · see citing works

Eosinophil differentiation factor also has B-cell growth factor activity: proposed name interleukin 4.

Sanderson, C. J., O’Garra, A., Warren, D. J., & Klaus, G. G. B. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.2.437 · Cited by 190 · see citing works

Purification to homogeneity of B cell stimulating factor. A molecule that stimulates proliferation of multiple lymphokine-dependent cell lines.

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Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells.

Greenbaum, L., Horowitz, J. B., Woods, A., et al. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.5.1555 · Cited by 180 · see citing works

Subpopulations of Thymus Cells and Thymus-Derived Lymphocytes

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Lymphocyte recruitment in delayed-type hypersensitivity. The role of IFN-gamma.

Issekutz, T. B., Stoltz, J. M., & van der Meide, P. H. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.9.2989 · Cited by 169 · see citing works

Distinct functional phenotypes of cloned Ia-restricted helper T cells.

Kim, J. P., Woods, A., Becker-Dunn, E., et al. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.162.1.188 · Cited by 167 · see citing works

Frequencies of IL-2- and IL-4-secreting T cells in naive and antigen-stimulated lymphocyte populations.

Powers, G. D., Abbas, A. K., & Miller, R. A. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.10.3352 · Cited by 163 · see citing works

Cloned helper T cells can kill B lymphoma cells in the presence of specific antigen: Ia restriction and cognate vs. noncognate interactions in cytolysis

Tite, J. P., & Janeway, C. A. (1984) · European Journal of Immunology · doi:10.1002/eji.1830141004 · Cited by 151 · see citing works

Alloreactive cloned T cell lines. VI. Multiple lymphokine activities secreted by helper and cytolytic cloned T lymphocytes.

Prystowsky, M. B., Ely, J. M., Beller, D. I., et al. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.6.2337 · Cited by 145 · see citing works

Interleukin 2 is both necessary and sufficient for the growth and differentiation of lectin-stimulated cytolytic T lymphocyte precursors.

Erard, F., Corthésy, P., Nabholz, M., et al. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.3.1644 · Cited by 142 · see citing works

Phenotypic and functional heterogeneity of CD4+ T cells

Powrie, F. M., & Mason, D. (1988) · Immunology Today · doi:10.1016/0167-5699(88)91309-6 · Cited by 141 · see citing works

Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes.

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B-cell stimulatory factor 1 and not interleukin 2 is the autocrine growth factor for some helper T lymphocytes.

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Murine B-cell stimulatory factor 1 (interleukin 4) increases expression of the Fc receptor for IgE on mouse B cells.

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Evidence for effects of interleukin 4 (B cell stimulatory factor 1) on macrophages: enhancement of antigen presenting ability of bone marrow-derived macrophages.

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Evidence for an immunoglobulin-dependent antigen-specific helper T cell.

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The Role of IL4 and IL5: Characterization of a Distinct Helper T Cell Subset that makes IL4 and IL5 (Th2) and Requires Priming before Induction of Lymphokine Secretion

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Opposing effects of glucocorticoids on interferon- gamma -induced murine macrophage Fc receptor and Ia antigen expression.

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Selectively increased production of interferon-gamma by subsets of Lyt-2+ and L3T4+ T cells identified by expression of Pgp-1.

Budd, R. C., Cerottini, J.-C., & MacDonald, H. R. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.11.3583 · Cited by 120 · see citing works

H-2 restriction of virus-specific T-cell-mediated effector functions in vivo. II. Adoptive transfer of delayed-type hypersensitivity to murine lymphocytic choriomeningits virus is restriced by the K and D region of H-2.

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Functional heterogeneity among the T-derived lymphocytes of the mouse. I. Analysis by adult thymectomy.

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Enhancement of IgG anti‐carrier responses by IgG2 anti‐hapten antibodies in mice

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Interleukin 4 mediates autocrine growth of helper T cells after antigenic stimulation.

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B-cell variant of mouse T200 (Ly-5): evidence for alternative mRNA splicing.

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Mice whose B cells cannot produce the T15 idiotype also lack an antigen-specific helper T cell required for T15 expression.

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Immunopathology of parasitic diseases: Involvement of basophils and mast cells

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Regulation of the immune response by subclasses of T lymphocytes. II. The effect of adult thymectomy upon humoral and cellular responses in mice

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Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells.

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T cell regulation of B cell activation. I-A-restricted T suppressor cells inhibit the major histocompatibility complex-restricted interactions of T helper cells with B cells and accessory cells.

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Characterization of two different Ly-1+ T cell populations that mediate delayed-type hypersensitivity.

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Alternative use of 5' exons in the specification of Ly-5 isoforms distinguishing hematopoietic cell lineages.

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Development of rat anti-mouse interleukin 3 monoclonal antibodies which neutralize bioactivity in vitro.

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Mast cells in severely T-cell depleted rats and the response to infestation with Nippostrongylus brasiliensis.

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Secretion of interleukin 2, macrophage-activating factor, interferon, and colony-stimulating factor by alloreactive T lymphocyte clones.

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Functional analysis of T cells expressing Ia antigens. I. Demonstration of helper T-cell heterogeneity.

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Interaction and Activation of Antigen‐Specific T and B Cells

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B cell stimulatory factor 1 (interleukin 4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors.

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Granulocyte-macrophage colony stimulating factor produced by cloned L3T4a+, class II-restricted T cells induces HT-2 cells to proliferate.

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Increased autoantibody production by NZB/NZW B cells in response to IL-5.

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Antigen-specific helper T-cell clone supernatant is sufficient to induce both polyclonal proliferation and differentiation of small resting B lymphocytes.

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Clearance of interleukin 2 from the blood of normal and T cell‐depleted mice

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The role of B cell surface Ia antigen recognition by T cells in B cell triggering. Analysis of the interaction of cloned helper T cells with normal B cells in differing states of activation and with B cells expressing the xid defect

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Reaginic antibodies and helminth infection

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Autocrine growth inhibition of a cloned line of helper T cells.

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Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen.

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Increase of precursor frequency and clonal size of murine IgE-secreting cells by IL-4.

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Cell-mediated and humoral immune responses in mice. III. Dynamic balance between delayed-type hypersensitivity and antibody response.

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Murine T-cell clones specific for chicken erythrocyte alloantigens

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Cell-Mediated and Humoral Immune Responses in Mice

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Reciprocity in Lymphocyte Interactions

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Antigen- and Lectin-Sensitized Murine Cytolytic T Lymphocyte-Precursors Require Both Interleukin 2 and Endogenously Produced Immune (γ) Interferon for Their Growth and Differentiation into Effector Cells

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Thymus‐Dependent Antigenic Stimulation of Hapten‐Specific B Lymphocytes

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