The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8
Open accessAbstract
A new neutrophil-activating peptide, termed ENA-78, was identified in the conditioned media of stimulated human type II epithelial cell line A549. In response to stimulation with either interleukin 1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF-alpha), ENA-78 was produced and secreted concomitantly with IL-8, GRO alpha, and GRO gamma. ENA-78 consists of 78 amino acids [sequence; see text] and has a molecular weight of 8,357. It has four cysteines positioned identically to those of IL-8 and analogues, and thus belongs to the CXC family of peptides. ENA-78 is related to neutrophil-activating peptide 2 (NAP-2) and GRO alpha (sequence identity, 53% and 52%, respectively) and IL-8 (22% identity). Like NAP-2 and GRO alpha, ENA-78 stimulates neutrophils, inducing chemotaxis, a rise in intracellular free calcium and exocytosis. Cross-desensitization experiments indicate that ENA-78 acts through the same type of receptors as IL-8, NAP-2, and GRO alpha.
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“Although the levels of KC, chemoattractant for neutrophils [57,58], were reduced in the THS-exposed mouse wounds the levels of LIX/ENA-78, another chemokine that chemoattracts neutrophils was present at normal levels [59].”
From Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing (2016) · cites this paper as [59]
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“Although the levels of KC, chemoattractant for neutrophils [57,58], were reduced in the THS-exposed mouse wounds the levels of LIX/ENA-78, another chemokine that chemoattracts neutrophils was present at normal levels [59].”
From Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing (2016) · cites this paper as [59]
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Citations
Cites
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Self-citationProperties Of The Novel Proinflammatory Supergene Intercrine Cytokine Family
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Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.
Baggiolini, M., Dewald, B., & Moser, B. (1994) · PubMed · Cited by 2,232
Self-citationInterleukin-8 as a macrophage-derived mediator of angiogenesis
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Self-citationlnterleukin-8 and Related Chemotactic Cytokines—CXC and CC Chemokines
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Self-citationThe Molecular Biology of Leukocyte Chemoattractant Receptors
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Interleukin‐8, a chemotactic and inflammatory cytokine
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Self-citation
Metadata
- Authors
- Walz, A., Burgener, R., Car, B., Baggiolini, M., Kunkel, S. L., & Strieter, R. M.
- Affiliations
- University of Bern (CH)
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1991-12-01
- Volume
- 174
- Issue
- 6
- Pages
- 1355-1362
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2119025
- OpenAlex
- W1970155928
- Cited by
- 353
- References
- 39
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 12 · 2013: 14 · 2012: 8
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k08hl002401-03, 5r01hl031237-32)
- National Heart, Lung, and Blood Institute (HL-02401, HL31237)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Keywords
- CXCL5, CXC chemokines, interleukin-8, neutrophil chemotaxis, IL-1β, TNF-α, A549 cells, intracellular calcium, exocytosis
- MeSH terms
- Amino Acid Sequence, Base Sequence, beta-Thromboglobulin, Calcium, Cell Line, Humans, Molecular Sequence Data, Neutrophils, Peptides, Interleukin-8, Chemokines, CXC, Chemokine CXCL5
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