Cited by 358Chemokine receptors and signalingInflammation biomarkers and pathwaysS100 Proteins and Annexins

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8

Open access

Walz, A, Burgener, R, Car, B, Baggiolini, M, Kunkel, S L, Strieter, R M·1991·The Journal of experimental medicine

DOI 10.1084/jem.174.6.1355PMC PMC2119025

Open this paper in CoChat — free account

Abstract

A new neutrophil-activating peptide, termed ENA-78, was identified in the conditioned media of stimulated human type II epithelial cell line A549. In response to stimulation with either interleukin 1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF-alpha), ENA-78 was produced and secreted concomitantly with IL-8, GRO alpha, and GRO gamma. ENA-78 consists of 78 amino acids [sequence; see text] and has a molecular weight of 8,357. It has four cysteines positioned identically to those of IL-8 and analogues, and thus belongs to the CXC family of peptides. ENA-78 is related to neutrophil-activating peptide 2 (NAP-2) and GRO alpha (sequence identity, 53% and 52%, respectively) and IL-8 (22% identity). Like NAP-2 and GRO alpha, ENA-78 stimulates neutrophils, inducing chemotaxis, a rise in intracellular free calcium and exocytosis. Cross-desensitization experiments indicate that ENA-78 acts through the same type of receptors as IL-8, NAP-2, and GRO alpha.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1084/jem.174.6.1355

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Grynkiewicz, G., Poenie, M., & Tsien, R. Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83641-4 · Cited by 21,562
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,460
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.
Baggiolini, M., Walz, A., & Kunkel, S. L. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114265 · Cited by 1,975
Self-citation
Properties Of The Novel Proinflammatory Supergene Intercrine Cytokine Family
Oppenheim, J. J., Zachariae, C. O. C., Mukaida, N., & Matsushima, K. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.003153 · Cited by 1,878
Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES
Schall, T. J., Bacon, K. B., Toy, K. J., & Goeddel, D. V. (1990) · Nature · doi:10.1038/347669a0 · Cited by 1,378
A continuous tumor‐cell line from a human lung carcinoma with properties of type II alveolar epithelial cells
Lieber, M. M., Todaro, G. J., Smith, B., Szakal, A. K., & Nelson‐Rees, W. A. (1976) · International Journal of Cancer · doi:10.1002/ijc.2910170110 · Cited by 1,311
Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines.
Yoshimura, T., Matsushima, K., Tanaka, S., Robinson, E. A., Appella, E., Oppenheim, J. J., & Leonard, E. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9233 · Cited by 984
Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β
Strieter, R. M., Kunkel, S. L., Showell, H. J., Remick, D. G., Phan, S. H., Ward, P. A., & Marks, R. M. (1989) · Science · doi:10.1126/science.2648570 · Cited by 775
Self-citation
Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung.
Standiford, T. J., Kunkel, S. L., Aseem Basha, M., Chensue, S. W., Lynch, J. P., Toews, G. B., Westwick, J. K., & Strieter, R. M. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114928 · Cited by 687
Self-citation

Show all 39 references

Sorted by citations

Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.
Baggiolini, M., Dewald, B., & Moser, B. (1994) · PubMed · Cited by 2,232
Self-citation
Interleukin-8 as a macrophage-derived mediator of angiogenesis
Koch, A. E., Polverini, P. J., Kunkel, S. L., Harlow, L. A., DiPietro, L. A., Elner, V. M., Elner, S. G., & Strieter, R. M. (1992) · Science · doi:10.1126/science.1281554 · Cited by 2,135
Self-citation
lnterleukin-8 and Related Chemotactic Cytokines—CXC and CC Chemokines
Baggiolini, M., Dewald, B., & Moser, B. (1993) · Advances in immunology · doi:10.1016/s0065-2776(08)60509-x · Cited by 1,672
Self-citation
The Molecular Biology of Leukocyte Chemoattractant Receptors
Murphy, P. M. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.003113 · Cited by 1,197
Interleukin‐8, a chemotactic and inflammatory cytokine
Baggiolini, M., & Clark‐Lewis, I. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80909-z · Cited by 991
Self-citation
Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor
Neote, K. S., DiGregorio, D. A., Mak, J. Y., Horuk, R., & Schall, T. J. (1993) · Cell · doi:10.1016/0092-8674(93)90118-a · Cited by 763
Inflammatory Mediators of Asthma: An Update
Barnes, P. J., Chung, K. F., & Page, C. P. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01381-4 · Cited by 715
Cytokine-mediated inflammation in acute lung injury
Goodman, R. B., Pugin, J., Lee, J. S., & Matthay, M. A. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00059-5 · Cited by 684
Cytokines in asthma
Chung, K. F., & Barnes, P. J. (1999) · Thorax · doi:10.1136/thx.54.9.825 · Cited by 654
RANTES and macrophage inflammatory protein 1 alpha induce the migration and activation of normal human eosinophil granulocytes.
Rot, A., Krieger, M., Brunner, T., Bischoff, S. C., Schall, T. J., & Dahinden, C. A. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.6.1489 · Cited by 611
CC chemokines in allergic inflammation
Baggiolini, M., & Dahinden, C. A. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90156-2 · Cited by 529
Self-citation
Inflammatory Cytokines in Patients With Persistence of the Acute Respiratory Distress Syndrome
Goodman, R. B., Strieter, R. M., Martin, D. P., Steinberg, K. P., MILBERG, J. A., Maunder, R. J., Kunkel, S. L., Walz, A., Hudson, L. D., & Martin, T. R. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.3.8810593 · Cited by 528
Self-citation
Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes.
Schall, T. J., Bacon, K. B., Camp, R. D. R., Kaspari, J. W., & Goeddel, D. V. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.6.1821 · Cited by 520
Chemokines IL-8, GROα, MCP-1, IP-10, and Mig Are Sequentially and Differentially Expressed During Phase-Specific Infiltration of Leukocyte Subsets in Human Wound Healing
Engelhardt, E., Toksoy, A., Goebeler, M., Debus, S., Bröcker, E.-B., & Gillitzer, R. (1998) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65699-4 · Cited by 435
IL-17 Enhances the Net Angiogenic Activity and In Vivo Growth of Human Non-Small Cell Lung Cancer in SCID Mice through Promoting CXCR-2-Dependent Angiogenesis
Numasaki, M., Watanabe, M., Suzuki, T., Takahashi, H., Nakamura, A., McAllister, F. M., Hishinuma, T., Goto, J., Lotze, M. T., Kolls, J. K., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.6177 · Cited by 424
Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice.
Arenberg, D. A., Kunkel, S. L., Polverini, P. J., Glass, M., Burdick, M. D., & Strieter, R. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118734 · Cited by 404
Self-citation
The T Cell-Specific CXC Chemokines IP-10, Mig, and I-TAC Are Expressed by Activated Human Bronchial Epithelial Cells
Sauty, A., Dziejman, M., Taha, R. A., Iarossi, A. S., Neote, K. S., García-Zepeda, E. A., Hamid, Q. A., & Luster, A. D. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3549 · Cited by 373
Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma
Zhou, S., Dai, Z., Zhou, Z., Wang, X., Yang, G., Wang, Z., Huang, X., Fan, J., & Zhou, J. (2012) · Hepatology · doi:10.1002/hep.25907 · Cited by 358
Biopsy Neutrophilia, Neutrophil Chemokine and Receptor Gene Expression in Severe Exacerbations of Chronic Obstructive Pulmonary Disease
Qiu, Y., Zhu, J., Bandi, V., Atmar, R. L., Hattotuwa, K., Guntupalli, K. K., & Jeffery, P. K. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200208-794oc · Cited by 357
Evasion from NK Cell Immunity by MHC Class I Chain-Related Molecules Expressing Colon Adenocarcinoma
Doubrovina, E. S., Doubrovin, M., Vider, J., Sisson, R. B., O’Reilly, R. J., Dupont, B., & Vyas, Y. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6891 · Cited by 329
When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system
Silva, M. T. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0809549 · Cited by 332
Chemokine receptors: Structure, function and role in microbial pathogenesis
Murphy, P. M. (1996) · Cytokine & Growth Factor Reviews · doi:10.1016/1359-6101(96)00009-3 · Cited by 320
Chemokines in acute respiratory distress syndrome
Puneet, P., Moochhala, S., & Bhatia, M. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00405.2003 · Cited by 312
Depletion of CXCR2 Inhibits Tumor Growth and Angiogenesis in a Murine Model of Lung Cancer
Keane, M. P., Belperio, J. A., Xue, Y., Burdick, M. D., & Strieter, R. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2853 · Cited by 312
Self-citation
Chemokines and tissue injury.
Furie, M. B., & Randolph, G. J. (1995) · Europe PMC (PubMed Central) · Cited by 297
The interleukin-8-related chemotactic cytokines GRO alpha, GRO beta, and GRO gamma activate human neutrophil and basophil leukocytes
Geiser, T., Dewald, B., Ehrengruber, M. U., Clark‐Lewis, I., & Baggiolini, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82274-8 · Cited by 281
Self-citation
Functional and biochemical analysis of the cloned Duffy antigen: identity with the red blood cell chemokine receptor
Neote, K. S., Mak, J., Kolakowski, L. J., & Schall, T. J. (1994) · Blood · doi:10.1182/blood.v84.1.44.44 · Cited by 277
K-ras activation generates an inflammatory response in lung tumors
Ji, H., Houghton, A. M., Mariani, T. J., Perera, S. A., Kim, C. B. Y., Padera, R. F., Tonon, G., McNamara, K. L., Marconcini, L. A. L., Hezel, A. F., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1209237 · Cited by 270
Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2.
Jones, S. A., Wolf, M., Qin, S., Mackay, C. R., & Baggiolini, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6682 · Cited by 265
Self-citation
Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis.
Koch, A. E., Kunkel, S. L., Harlow, L. A., Mazarakis, D. D., Haines, G. K., Burdick, M. D., Pope, R. M., Walz, A., & Strieter, R. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117414 · Cited by 265
Self-citation
Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer.
Arenberg, D. A., Keane, M. P., DiGiovine, B., Kunkel, S. L., Morris, S. B., Xue, Y. Y., Burdick, M. D., Glass, M. C., Iannettoni, M. D., & Strieter, R. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3145 · Cited by 259
Self-citation
Platelet factor 4 binds to interleukin 8 receptors and activates neutrophils when its N terminus is modified with Glu-Leu-Arg.
Clark‐Lewis, I., Dewald, B., Geiser, T., Moser, B., & Baggiolini, M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3574 · Cited by 258
Self-citation
The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization.
Bozic, C. R., Gerard, N. P., von UEXKULL, C., Kolakowski, L. F., Conklyn, M. J., Breslow, R., Showell, H. J., & Gerard, C. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43882-3 · Cited by 256
Role of C-X-C chemokines as regulators of angiogenesis in lung cancer
Strieter, R. M., Polverini, P. J., Arenberg, D. A., Walz, A., Opdenakker, G., Damme, J. V., & Kunkel, S. L. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.57.5.752 · Cited by 246
Self-citation
Chemokines and their receptors in rheumatoid arthritis: Future targets?
Koch, A. E. (2005) · Arthritis & Rheumatism · doi:10.1002/art.20932 · Cited by 253
Chemokines and chemokine receptors in rheumatoid arthritis
Szekanecz, Z., Kim, J., & Koch, A. E. (2002) · Seminars in Immunology · doi:10.1016/s1044-5323(02)00124-0 · Cited by 247
Interleukin‐8 processing by neutrophil elastase, cathepsin G and proteinase‐3
Padrines, M., Wolf, M., Walz, A., & Baggiolini, M. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00952-x · Cited by 235
Self-citation
Chemokine expression during hepatic ischemia/reperfusion-induced lung injury in the rat. The role of epithelial neutrophil activating protein.
Colletti, L. M., Kunkel, S. L., Walz, A., Burdick, M. D., Kunkel, R. G., Wilke, C. A., & Strieter, R. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117630 · Cited by 235
Self-citation
Monocyte Chemoattractant Protein‐1 (CCL2) in Inflammatory Disease and Adaptive Immunity: Therapeutic Opportunities and Controversies
Daly, C. M., & Rollins, B. J. (2003) · Microcirculation · doi:10.1038/sj.mn.7800190 · Cited by 232
Cervical remodeling during pregnancy and parturition: molecular characterization of the softening phase in mice
Read, C. P., Word, R. A., Ruscheinsky, M., Timmons, B. C., & Mahendroo, M. (2007) · Reproduction · doi:10.1530/rep-07-0032 · Cited by 218
RANTES and related chemokines activate human basophil granulocytes through different G protein‐coupled receptors
Bischoff, S. C., Krieger, M., Brunner, T., Rot, A., Tscharner, V., Baggiolini, M., & Dahinden, C. A. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230329 · Cited by 215
Self-citation
CXCL5 contributes to tumor metastasis and recurrence of intrahepatic cholangiocarcinoma by recruiting infiltrative intratumoral neutrophils
Zhou, S., Dai, Z., Zhou, Z., Chen, Q., Wang, Z., Xiao, Y., Hu, Z., Huang, X., Yang, G., Shi, Y., et al. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt397 · Cited by 197
The murine neutrophil-chemoattractant chemokines LIX, KC, and MIP-2 have distinct induction kinetics, tissue distributions, and tissue-specific sensitivities to glucocorticoid regulation in endotoxemia
Rovai, L. E., Herschman, H. R., & Smith, J. B. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.64.4.494 · Cited by 189
Identifying Strategies for Immune Intervention
Lanzavecchia, A. (1993) · Science · doi:10.1126/science.8493532 · Cited by 191
Venous Thrombosis–Associated Inflammation and Attenuation With Neutralizing Antibodies to Cytokines and Adhesion Molecules
Wakefield, T. W., Strieter, R. M., Wilke, C. A., Kadell, A. M., Wrobleski, S. K., Burdick, M. D., Schmidt, R., Kunkel, S. L., & Greenfield, L. J. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.2.258 · Cited by 184
Self-citation
Toll-Like Receptor 5 Engagement Modulates Tumor Development and Growth in a Mouse Xenograft Model of Human Colon Cancer
Rhee, S. H., Im, E., & Pothoulakis, C. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.022 · Cited by 186
CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance
Chavey, C., Lazennec, G., Lagarrigue, S., Clapé, C., Iankova, I., Teyssier, J., Annicotte, J., Schmidt, J., Mataki, C., Yamamoto, H., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.002 · Cited by 187
Self-citation
Structural requirements for interleukin-8 function identified by design of analogs and CXC chemokine hybrids.
Clark‐Lewis, I., Dewald, B., Loetscher, M., Moser, B., & Baggiolini, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33975-3 · Cited by 181
Self-citation
Markers of Intestinal Inflammation, Not Bacterial Burden, Correlate With Clinical Outcomes in Clostridium difficile Infection
Feghaly, R. E. E., Stauber, J. L., Deych, E., Gonzalez, C., Tarr, P. I., & Haslam, D. B. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit147 · Cited by 178
Overexpression of CXCL5 Is Associated With Poor Survival in Patients With Pancreatic Cancer
Li, A., King, J. C., Moro, A., Sugi, M. D., Dawson, D. W., Kaplan, J., Li, G., Lu, X., Strieter, R. M., Burdick, M. D., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.058 · Cited by 178
Self-citation
Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms
Bezzi, M., Seitzer, N., Ishikawa, T., Reschke, M., Chen, M., Wang, G., Mitchell, C., Ng, C., Katon, J. M., Lunardi, A., et al. (2018) · Nature Medicine · doi:10.1038/nm.4463 · Cited by 179
Platelet chemokines and their receptors: what is their relevance to platelet storage and transfusion practice?
Boehlen, F., & Clemetson, K. J. (2001) · Transfusion Medicine · doi:10.1046/j.1365-3148.2001.00340.x · Cited by 159
The role of CXC chemokines in the regulation of angiogenesis in non-small cell lung cancer
Arenberg, D. A., Polverini, P. J., Kunkel, S. L., Shanafelt, A. B., Hesselgesser, J., Horuk, R., & Strieter, R. M. (1997) · Journal of Leukocyte Biology · doi:10.1002/jlb.62.5.554 · Cited by 158
Self-citation
Increased levels of interleukin-8 in BAL fluid from smokers susceptible to pulmonary emphysema
Tanino, M. A. (2002) · Thorax · doi:10.1136/thorax.57.5.405 · Cited by 156
The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer
Verbeke, H., Karel, G., Damme, J. V., & Struyf, S. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.10.008 · Cited by 157
A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: requirements for adherence and chemokine release
Wyman, T. H., Bjornsen, A. J., Elzi, D. J., Smith, C. W., England, K. M., Kelher, M. R., & Silliman, C. C. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00540.2001 · Cited by 152
Acute generalized exanthematous pustulosis, a clue to neutrophil-mediated inflammatory processes orchestrated by T cells
Britschgi, M., & Pichler, W. J. (2002) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/00130832-200208000-00006 · Cited by 149
Pulmonary epithelial cells are a source of IL-8 in the response to Mycobacterium tuberculosis: essential role of IL-1 from infected monocytes in a NF-kappa B-dependent network.
Wickremasinghe, M., Thomas, L. H., & Friedland, J. S. (1999) · PubMed · Cited by 149
Chemokines
Rollins, B. J. (1997) · Blood · doi:10.1182/blood.v90.3.909.909_909_928 · Cited by 2,126
Characterization of Synthetic Human Granulocyte Chemotactic Protein 2: Usage of Chemokine Receptors CXCR1 and CXCR2 andin VivoInflammatory Properties
Wuyts, A., Osselaer, N. V., Haelens, A., Samson, I., Herdewijn, P. A., Ben‐Baruch, A., Oppenheim, J. J., Proost, P., & Damme, J. V. (1997) · Biochemistry · doi:10.1021/bi961999z · Cited by 146
Differential Expression of GRO-α and IL-8 mRNA Psoriasis: A Model for Neutrophil Migration and Accumulation In Vivo
Gillitzer, R., Ritter, U., Spandau, U. H., Goebeler, M., & Bröcker, E.-B. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12371803 · Cited by 143
Cytokines in Metal Fume Fever
Blanc, P. D., Boushey, H. A., Wong, H. H., Wintermeyer, S. F., & Bernstein, M. S. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/147.1.134 · Cited by 140
Targeting Chemokine—Glycosaminoglycan Interactions to Inhibit Inflammation
Crijns, H., Vanheule, V., & Proost, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00483 · Cited by 139
Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis.
Shimoyama, T., Everett, S. M., Dixon, M. F., Axon, A. T. R., & Crabtree, J. E. (1998) · Journal of Clinical Pathology · doi:10.1136/jcp.51.10.765 · Cited by 139
Interleukin-8 antagonists generated by N-terminal modification.
Moser, B., Dewald, B., Barella, L., Schumacher, C., Baggiolini, M., & Clark‐Lewis, I. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53154-9 · Cited by 137
Self-citation
CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils
Mao, Z., Zhang, J., Shi, Y., Li, W., Shi, H., Ji, R., Mao, F., Qian, H., Xu, W., & Zhang, X. (2020) · Oncogenesis · doi:10.1038/s41389-020-00249-z · Cited by 136
The expression and role of CXC chemokines in colorectal cancer
Verbeke, H., Struyf, S., Laureys, G., & Damme, J. V. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.09.002 · Cited by 139
Profiling Early Lung Immune Responses in the Mouse Model of Tuberculosis
Kang, D., Lin, Y., Rangel‐Moreno, J., Randall, T. D., & Khader, S. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016161 · Cited by 138
The CXC-Chemokine Neutrophil-Activating Peptide-2 Induces Two Distinct Optima of Neutrophil Chemotaxis by Differential Interaction With Interleukin-8 Receptors CXCR-1 and CXCR-2
Ludwig, A., Petersen, F., Zahn, S., Götze, O., Schröder, J., Flad, H., & Brandt, E. (1997) · Blood · doi:10.1182/blood.v90.11.4588 · Cited by 127
Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene.
Chang, M., McNinch, J. S., Basu, R., & Simonet, S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47243-2 · Cited by 125
Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients
Decalf, J., Fernandes, S., Longman, R., Ahloulay, M., Audat, F., Lefrerre, F., Rice, C. M., Pol, S., & Albert, M. L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070814 · Cited by 125
Differential expression of chemokines in normal pancreas and in chronic pancreatitis
Saurer, L., Reber, P. U., Schaffner, T. J., Büchler, M. W., Buri, C., Каппелер, А., Walz, A., Frieß, H., & Mueller, C. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70218-6 · Cited by 125
Self-citation
Pulmonary Epithelial Cells are a Source of IL-8 in the Response to Mycobacterium tuberculosis : Essential Role of IL-1 from Infected Monocytes in a NF-κB-Dependent Network
Wickremasinghe, M., Thomas, L. H., & Friedland, J. S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.3936 · Cited by 125
Granulocyte-Colony Stimulating Factor and Lipopolysaccharide Regulate the Expression of Interleukin 8 Receptors on Polymorphonuclear Leukocytes
Lloyd, A. R., Biragyn, A., Johnston, J. A., Taub, D. D., Xu, L., Michiel, D. F., Sprenger, H., Oppenheim, J. J., & Kelvin, D. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.47.28188 · Cited by 123
Identification of cytokine-induced neutrophil chemoattractants (CINC), rat GRO/CINC-2α and CINC-2 β, produced by granulation tissue in culture: purification, complete amino acid sequences and characterization
Nakagawa, H., Komorita, N., Shibata, F., Ikesue, A., Konishi, K., Fujioka, M., & Kato, H. (1994) · Biochemical Journal · doi:10.1042/bj3010545 · Cited by 121
Discovery of 2-Hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): A Potent, Orally Bioavailable CXCR2/CXCR1 Receptor Antagonist
Dwyer, M. P., Yu, Y., Chao, J., Aki, C., Chao, J., Biju, P., GIRIJAVALLABHAN, V. M., Rindgen, D., Bond, R. W., Mayer-Ezel, R., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm0609622 · Cited by 120
Transforming Growth Factor‐β and Axl Induce CXCL5 and Neutrophil Recruitment in Hepatocellular Carcinoma
Haider, C., Hnat, J., Wagner, R., Huber, H., Timelthaler, G., Grubinger, M., Coulouarn, C., Schreiner, W., Schlangen, K., Sieghart, W., et al. (2018) · Hepatology · doi:10.1002/hep.30166 · Cited by 117
CXCL5 Mediates UVB Irradiation–Induced Pain
Dawes, J. M., Calvo, M., Perkins, J. R., Paterson, K. J., Kiesewetter, H., Hobbs, C., Kaan, T. K. Y., Orengo, C. A., Bennett, D., & McMahon, S. B. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002193 · Cited by 116
Expression of the neutrophil‐activating CXC chemokine ENA‐78/CXCL5 by human eosinophils
Persson, T., Monsef, N., Andersson, P., Bjartell, A. S., Malm, J., Calafat, J., & Egesten, A. (2003) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2003.01609.x · Cited by 115
IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3)
Henkels, K. M., Frondorf, K. A., González-Mejía, M. E., Doseff, A. I., & Gómez-Cambronero, J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.11.031 · Cited by 115
Chemokines in Lung Injury
Strieter, R. M., Kunkel, S. L., Keane, M. P., & Standiford, T. J. (1999) · CHEST Journal · doi:10.1378/chest.116.suppl_1.103s · Cited by 115
Self-citation
Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases
Bodolay, E., Koch, A. E., Kim, J. M., Szegedi, G., & Szekanecz, Z. (2002) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2002.tb00514.x · Cited by 113
Effect of exposure to swine dust on levels of IL-8 in airway lavage fluid
Larsson, B., Palmberg, L., Malmberg, P., & Larsson, K. (1997) · Thorax · doi:10.1136/thx.52.7.638 · Cited by 113
Regulation of chemokine activity by posttranslational modification
Mortier, A., Damme, J. V., & Proost, P. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.08.006 · Cited by 112
Inhibition of endothelial cell proliferation by platelet factor-4 involves a unique action on S phase progression.
Gupta, S. K., & Singh, J. P. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.4.1121 · Cited by 112
Transcriptional response of human microglial cells to interferon-γ
Rock, R. B., Hu, S., Deshpande, A., Munir, S., May, B. J., Baker, C. A., Peterson, P. K., & Kapur, V. (2005) · Genes and Immunity · doi:10.1038/sj.gene.6364246 · Cited by 111
Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease.
Müller, S., Lory, J., Corazza, N., Griffiths, G. M., Z’graggen, K., Mazzucchelli, L., Каппелер, А., & Mueller, C. (1998) · Europe PMC (PubMed Central) · Cited by 110
Chemokines in rheumatoid arthritis
Szekanec, Z., Strieter, R. M., Kunkel, S. L., & Koch, A. E. (1998) · Springer Seminars in Immunopathology · doi:10.1007/bf00832002 · Cited by 104
Self-citation
Molecular evolution of the human interleukin–8 receptor gene cluster
Ahuja, S. K., Özçelık, T., Milatovich, A., Francke, U., & Murphy, P. M. (1992) · Nature Genetics · doi:10.1038/ng0992-31 · Cited by 105
CXCL5 overexpression is associated with late stage gastric cancer
Park, J. Y., Park, K. H., Bang, S., Kim, M., Lee, J.-E., Gang, J., Koh, S. S., & Song, S. Y. (2007) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-007-0225-x · Cited by 105
Cytokines. 2. Cytokines and lung inflammation: mechanisms of neutrophil recruitment to the lung.
Strieter, R. M., Lukacs, N. W., Standiford, T. J., & Kunkel, S. L. (1993) · Thorax · doi:10.1136/thx.48.7.765 · Cited by 102
Self-citation
Structure and Function of Leukocyte Chemoattractant Receptors
Ye, R. D., & Boulay, F. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60073-3 · Cited by 99
Beyond Chemoattraction: Multifunctionality of Chemokine Receptors in Leukocytes
López-Cotarelo, P., Gómez-Moreira, C., Criado‐García, O., Sánchez, L., & Rodríguez‐Fernández, J. L. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.08.004 · Cited by 99
ZBP-89, Sp1, and Nuclear Factor-κB Regulate Epithelial Neutrophil-activating Peptide-78 Gene Expression in Caco-2 Human Colonic Epithelial Cells
Keates, A. C., Keates, S. E., Kwon, J. H., Arseneau, K. O., Law, D., Bai, L., Merchant, J. L., Wang, T. C., & Kelly, C. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107838200 · Cited by 95
Amino-Terminal Processing of Chemokine ENA-78 Regulates Biological Activity
Nufer, O., Corbett, M. S., & Walz, A. (1998) · Biochemistry · doi:10.1021/bi981294s · Cited by 93
Self-citation
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression
Xu, W. W., Li, B., Guan, X., Chung, S. K., Wang, Y., Yip, Y. L., Law, S. Y.-K., Chan, K. T., Lee, N. P. Y., Chan, K. W., et al. (2017) · Nature Communications · doi:10.1038/ncomms14399 · Cited by 91
Release of CXC-chemokines by human lung microvascular endothelial cells (LMVEC) compared with macrovascular umbilical vein endothelial cells
Beck, G. C., Yard, B. A., Breedijk, A. J., van Ackern, K., & van der Woude, F. J. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.01052.x · Cited by 91
Chemokines: Function, Regulation and Alteration of Inflammatory Responses
Lukacs, N. W., Hogabaom, C., Campbell, E., & Kunkel, S. L. (1999) · KARGER eBooks · doi:10.1159/000058729 · Cited by 91
Self-citation
Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2
Lehman, N., Fulvio, M. D., McCray, N., Campos, I., Tabatabaian, F., & Gómez-Cambronero, J. (2006) · Blood · doi:10.1182/blood-2006-02-005959 · Cited by 91
A CXCL5- and bFGF-dependent effect of PDGF-B-activated fibroblasts in promoting trafficking and differentiation of bone marrow-derived mesenchymal stem cells
Nedeau, A. E., Bauer, R. J., Gallagher, K. A., Chen, H., Liu, Z., & Velazquez, O. C. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.04.007 · Cited by 90

Authors: Walz, A., Burgener, R., Car, B., Baggiolini, M., Kunkel, S. L., & Strieter, R. M.
Affiliations: University of Bern (CH)
ORCID: Kunkel, S L
Strieter, R M
Venue: The Journal of experimental medicine
Publisher: Rockefeller University Press
Published: 1991-12-01
Volume: 174
Issue: 6
Pages: 1355-1362
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.174.6.1355
PMC: PMC2119025
OpenAlex: W1970155928
Cited by: 353
References: 39
Citations by year: 2026: 2 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 12 · 2013: 14 · 2012: 8
FWCI: 7.71
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k08hl002401-03, 5r01hl031237-32)
National Heart, Lung, and Blood Institute (HL-02401, HL31237)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
Keywords: CXCL5, CXC chemokines, interleukin-8, neutrophil chemotaxis, IL-1β, TNF-α, A549 cells, intracellular calcium, exocytosis
MeSH terms: Amino Acid Sequence, Base Sequence, beta-Thromboglobulin, Calcium, Cell Line, Humans, Molecular Sequence Data, Neutrophils, Peptides, Interleukin-8, Chemokines, CXC, Chemokine CXCL5

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks