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Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor.
Open accessAbstract
Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells in culture, is expressed in vivo in a variety of inflammatory conditions associated with cell proliferation, including atherosclerosis, wound repair, pulmonary fibrosis, and glomerulonephritis. However, it is not known if PDGF mediates the fibroproliferative responses that characterize these inflammatory disorders. We administered neutralizing anti-PDGF IgG or control IgG to rats with mesangial proliferative nephritis. Inhibition of PDGF resulted in a significant reduction in mesangial cell proliferation, and largely prevented the increased deposition of extracellular matrix associated with the disease. This suggests that PDGF may have a central role in proliferative glomerular disease.
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Citations
Cited by
Regulation of PDGF and its receptors in fibrotic diseases
Bonner, J. C. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.03.006 · Cited by 768
Distler, J. H. W., Jüngel, A., Huber, L. C., Schulze‐Horsel, U., Zwerina, J., Gay, R. E., Michel, B. A., Hauser, T., Schett, G., Gay, S., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22314 · Cited by 383
Immune and Inflammatory Role in Renal Disease
Imig, J. D., & Ryan, M. J. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c120028 · Cited by 356
Cellular events in the evolution of experimental diabetic nephropathy
Young, B. A., Johnson, R. J., Alpers, C. E., Eng, E., Gordon, K., Floege, J., Couser, W. G., & Seidel, W. T. S. A. F. S. K. (1995) · Kidney International · doi:10.1038/ki.1995.139 · Cited by 318
Self-citationMizuno, S., Kurosawa, T., Matsumoto, K., Mizuno-Horikawa, Y., Okamoto, M., & Nakamura, T. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1709 · Cited by 254
Metadata
- Authors
- Johnson, R. J., Raines, E. W., Floege, J., Yoshimura, A., Pritzl, P., Alpers, C., & Ross, R.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1992-05-01
- Volume
- 175
- Issue
- 5
- Pages
- 1413-1416
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1970709922
- Cited by
- 341
- References
- 0
- FWCI
- 21.16
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor. https://app.cochat.ai/papers/10.1084/jem.175.5.1413
- The paper
- Johnson, R. J., Raines, E. W., Floege, J., Yoshimura, A., Pritzl, P., Alpers, C., & Ross, R. (1992). Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor. The Journal of experimental medicine. https://doi.org/10.1084/jem.175.5.1413
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
