Regulation of PDGF and its receptors in fibrotic diseases

Bonner, James C

doi:10.1016/j.cytogfr.2004.03.006

Cited by 768Liver physiology and pathologyTGF-β signaling in diseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Regulation of PDGF and its receptors in fibrotic diseases

Bonner, James C·2004·Cytokine & Growth Factor Reviews

DOI 10.1016/j.cytogfr.2004.03.006

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Abstract

Platelet-derived growth factor (PDGF) isoforms play a major role in stimulating the replication, survival, and migration of myofibroblasts during the pathogenesis of fibrotic diseases. During fibrogenesis, PDGF is secreted by a variety of cell types as a response to injury, and many pro-inflammatory cytokines mediate their mitogenic effects via the autocrine release of PDGF. PDGF action is determined by the relative expression of PDGF alpha-receptors (PDGFRalpha) and beta-receptors (PDGFRbeta) on the surface of myofibroblasts. These receptors are induced during fibrogenesis, thereby amplifying biological responses to PDGF isoforms. PDGF action is also modulated by extracellular binding proteins and matrix molecules. This review summarizes the literature on the role of PDGF and its receptors in the development of fibrosis in a variety of organ systems, including lung, liver, kidney, and skin.

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PDGF released by macrophages induces proliferation of myofibroblasts, which over time cover the entire surface of the implant.
“PDGF—also released by macrophages—induces the proliferation of myofibroblasts, which over time cover the entire surface of the implant (Bonner, 2004).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Bonner, 2004

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Authors: Bonner, J. C.
Affiliations: National Institute of Environmental Health Sciences (US)
Corresponding author: Bonner, James C
ORCID: Bonner, James C
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 2004-08
Volume: 15
Issue: 4
Pages: 255-273
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/j.cytogfr.2004.03.006
OpenAlex: W2002999999
Cited by: 768
References: 190
Citations by year: 2026: 29 · 2025: 29 · 2024: 29 · 2023: 29 · 2022: 26 · 2021: 42 · 2020: 38 · 2019: 41 · 2018: 32 · 2017: 43 · 2016: 47 · 2015: 41 · 2014: 44 · 2013: 39 · 2012: 56
FWCI: 3.10
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cytokine & Growth Factor Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Keywords: platelet-derived growth factor, PDGF receptor, PDGFRA, PDGFRβ, fibrosis, fibrogenesis, myofibroblasts, autocrine signaling, inflammatory cytokines, extracellular matrix, pulmonary fibrosis, liver fibrosis, renal fibrosis, skin fibrosis
MeSH terms: Animals, Fibroblasts, Fibrosis, Gene Expression Regulation, Humans, Inflammation, Interleukin-1, Kidney, Liver, Lung, Models, Biological, Muscles, Platelet-Derived Growth Factor, Scleroderma, Systemic, Tissue Distribution, Signal Transduction, Transforming Growth Factor beta, Protein Isoforms, Receptor, Platelet-Derived Growth Factor alpha, Receptor, Platelet-Derived Growth Factor beta, Transforming Growth Factor beta1

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Regulation of PDGF and its receptors in fibrotic diseases

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