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Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer
Open accessAbstract
Moloney Murine Leukemia Virus (MoMuLV) causes T cell neoplasms in rodents but is not known to be a pathogen in primates. The core protein and enzyme genes of the MoMuLV genome together with an amphotropic envelope gene are utilized to engineer the cell lines that generate retroviral vectors for use in current human gene therapy applications. We developed a producer clone that generates a very high concentration of retroviral vector particles to optimize conditions for gene insertion into pluripotent hematopoietic stem cells. This producer cell line also generates a much lower concentration of replication-competent virus that arose through recombination. Stem cells from rhesus monkeys were purified by immunoselection with an anti-CD34 antibody, incubated in vitro for 80-86 h in the presence of retroviral vector particles with accompanying replication-competent virus and used to reconstitute recipients whose bone marrow had been ablated by total body irradiation. The retroviral vector genome was detected in circulating cells of five of eight transplant recipients of CD34+ cells and in the circulating cells of two recipients of infected, unfractionated bone marrow mononuclear cells. Three recipients of CD34+ cells had a productive infection with replication-competent virus. Six or seven mo after transplantation, each of these animals developed a rapidly progressive T cell neoplasm involving the thymus, lymph nodes, liver, spleen, and bone marrow. Lymphoma cells contained 10-50 copies of the replication-competent virus, but lacked the retroviral vector genome. We conclude that replication-competent viruses arising from producer cells making retroviral vectors can be pathogenic in primates, which underscores the importance of carefully screening retroviral producer clones used in human trials to exclude contamination with replication-competent virus.
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“Although viral vectors have been widely used in the delivery of the CRISPR/Cas9 system in vitro and in vivo, their fundamental shortcomings, such as the risk of carcinogenesis, limited insertion size, immune responses and difficulty in large-scale production, severely limit their further applications.”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [71]
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Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Kishimoto, T. (1989) · Blood · doi:10.1182/blood.v74.1.1.bloodjournal7411 · Cited by 2,068
Improved retroviral vectors for gene transfer and expression.
Miller, A. D., & Rosman, G. J. (1989) · PubMed · Cited by 1,990
Mann, R., Mulligan, R. C., & Baltimore, D. (1983) · Cell · doi:10.1016/0092-8674(83)90344-6 · Cited by 1,776
Miller, A. D., & Buttimore, C. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.8.2895-2902.1986 · Cited by 1,371
Granulocyte colony-stimulating factor and its receptor
Demetri, G. D., & Griffin, J. D. (1991) · Blood · doi:10.1182/blood.v78.11.2791.2791 · Cited by 1,066
A safe packaging line for gene transfer: separating viral genes on two different plasmids
Markowitz, D., Goff, S. P., & Bank, A. (1988) · Journal of Virology · doi:10.1128/jvi.62.4.1120-1124.1988 · Cited by 1,062
Danos, O., & Mulligan, R. C. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6460 · Cited by 898
Yang, Y., Ciarletta, A. B., Temple, P. A., Chung, M. P., Kovacic, S., Witek-Giannotti, J. S., Leary, A. C., Kriz, R., Donahue, R. E., Wong, G. G., et al. (1986) · Cell · doi:10.1016/0092-8674(86)90360-0 · Cited by 766
Self-citationPrimary structure and functional expression of rat and human stem cell factor DNAs
Martin, F. H., Suggs, S. V., Langley, K. E., Lu, H. S., Ting, J., Okino, K. H., Morris, C. F., McNiece, I., Jacobsen, F. W., Mendlaz, E. A., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90301-t · Cited by 719
Cited by
Sorted by citations
Items 101–200 of 525
The new frontier: gene and oligonucleotide therapy
Schreier, H. (1994) · Pharmaceutica Acta Helvetiae · doi:10.1016/0031-6865(94)90037-x · Cited by 62
Psi- vectors: murine leukemia virus-based self-inactivating and self-activating retroviral vectors
Delviks‐Frankenberry, K. A., Hu, W.-S., & Pathak, V. K. (1997) · Journal of Virology · doi:10.1128/jvi.71.8.6218-6224.1997 · Cited by 60
Gene transfer: A review of methods and applications
Prince, H. M. (1998) · Pathology · doi:10.1080/00313029800169606 · Cited by 60
Xu, L. C., Karlsson, S., Byrne, E. R., Kluepfel-Stahl, S., Kessler, S., Agricola, B. A., Sellers, S. E., Kirby, M., Dunbar, C. E., & Brady, R. O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4372 · Cited by 60
Self-citationBear, A. S., Morgan, R. A., Cornetta, K., June, C. H., Binder-Scholl, G., Dudley, M. E., Feldman, S. A., Rosenberg, S. A., Shurtleff, S. A., Rooney, C. M., et al. (2012) · Molecular Therapy · doi:10.1038/mt.2011.288 · Cited by 59
Toolbox for retrovectorologists
Pagès, J., & Bru, T. (2004) · Journal of Gene Medicine · doi:10.1002/jgm.498 · Cited by 60
Prospects for gene therapy of haemophilia
Nathwani, A. C., Davidoff, A. M., & Tuddenham, E. G. D. (2004) · Haemophilia · doi:10.1111/j.1365-2516.2004.00926.x · Cited by 57
Long, Z., Lie-ping, L., Grooms, T., Lockey, C., Nader, K., Mychkovsky, I., Mueller, S. N., Burimski, I., Ryan, P. C., Kikuchi, G. E., et al. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.8-1165 · Cited by 57
Non-viral gene transfection technologies for genetic engineering of stem cells
Jo, J., & Tabata, Y. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.04.021 · Cited by 56
The Common Marmoset as a Target Preclinical Primate Model for Cytokine and Gene Therapy Studies
Hibino, H., Tani, K., Ikebuchi, K., Wu, M., Sugiyama, H., Nakazaki, Y., Tanabe, T., Takahashi, S., Tojo, A., Suzuki, S., et al. (1999) · Blood · doi:10.1182/blood.v93.9.2839 · Cited by 56
Vile, R. G., Tuszynski, A., & Castleden, S. (1996) · Molecular Biotechnology · doi:10.1007/bf02789062 · Cited by 56
Genetic Reassortment and Patch Repair by Recombination in Retroviruses
Mikkelsen, J. G., & Pedersen, F. S. (2000) · Journal of Biomedical Science · doi:10.1007/bf02256615 · Cited by 56
Wilson, C. A., Ng, T., & Miller, A. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.7-869 · Cited by 56
Replicating vectors for gene therapy of cancer: risks, limitations and prospects
Russell, S. J. (1994) · European Journal of Cancer · doi:10.1016/0959-8049(94)90477-4 · Cited by 56
Porcine Endogenous Retroviruses in Xenotransplantation—Molecular Aspects
Kimsa‐Dudek, M., Strzałka‐Mrozik, B., Kimsa-Furdzik, M., Gola, J. M., Nicholson, P., Łopata, K., & Mazurek, U. M. (2014) · Viruses · doi:10.3390/v6052062 · Cited by 55
Alallam, B., Altahhan, S., Taher, M., Nasir, M. H. M., & Doolaanea, A. A. (2020) · Pharmaceuticals · doi:10.3390/ph13080158 · Cited by 56
Kung, S. K. P., An, D. S., & Chen, I. S. Y. (2000) · Journal of Virology · doi:10.1128/jvi.74.8.3668-3681.2000 · Cited by 55
Replication-competent Lentivirus Analysis of Clinical Grade Vector Products
Cornetta, K., Yao, J., Jasti, A., Koop, S., Douglas, M., Hsu, D., Couture, L. A., Hawkins, T., & Duffy, L. (2011) · Molecular Therapy · doi:10.1038/mt.2010.278 · Cited by 55
Ponnazhagan, S., Weigel-Kelley, K. A., Raikwar, S. P., Mukherjee, P., Yöder, M. C., & Srivastava, A. (1998) · Journal of Virology · doi:10.1128/jvi.72.6.5224-5230.1998 · Cited by 54
Cytokine-mediated gene therapy for cancer
Miller, A. R., McBride, W. H., Hunt, K. K., & Economou, J. S. (1994) · Annals of Surgical Oncology · doi:10.1007/bf02303818 · Cited by 54
Ponnazhagan, S., Nallari, M. L., & Srivastava, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.2.733 · Cited by 53
Clinical Development of Gene Therapies: The First Three Decades and Counting
Lapteva, L., Purohit-Sheth, T., Serabian, M. A., & Puri, R. K. (2020) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2020.10.004 · Cited by 54
Transspecies transmissions of retroviruses: New cases
Denner, J. (2007) · Virology · doi:10.1016/j.virol.2007.07.026 · Cited by 52
Hosseinkhani, H., Aoyama, T., Ogawa, O., & Tabata, Y. (2002) · Journal of drug targeting · doi:10.1080/10611860290022624 · Cited by 51
RetractedDifferentiation, differentiation/gene therapy and cancer
Scott, R. E. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(96)00120-9 · Cited by 51
Virus vector design in gene therapy
Günzburg, W. H., & Salmons, B. (1995) · Molecular Medicine Today · doi:10.1016/s1357-4310(95)90771-8 · Cited by 51
Hara, T., Aramaki, Y., Takada, S., Koike, K., & Tsuchiya, S. (1995) · Gene · doi:10.1016/0378-1119(95)00100-k · Cited by 50
Welfare Issues of Genetically Modified Animals
Dennis, M. B. (2002) · ILAR Journal · doi:10.1093/ilar.43.2.100 · Cited by 51
Eguchi, S., Rózga, J., Lebow, L. T., Chen, S. C., Wang, C., Rosenthal, R. J., Fogli, L., Hewitt, W. R., Middleton, Y., & Demetriou, A. A. (1996) · Transplantation · doi:10.1097/00007890-199609150-00008 · Cited by 48
Noninfectious Gene Transfer and Expression Systems for Cancer Gene Therapy
Cooper, M. J. (2002) · Elsevier eBooks · doi:10.1016/b978-012437551-2/50003-3 · Cited by 48
Tri-peptide cationic lipids for gene delivery
Zhao, Y., Zhang, S., Zhang, Y., Cui, S., Chen, H., Zhi, D., Zhen, Y., Zhang, S., & Huang, L. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb01312c · Cited by 47
Tissue-Specific Transcriptional Targeting of a Replication-Competent Retroviral Vector
Logg, C. R., Logg, A., Matusik, R. J., Bochner, B. H., & Kasahara, N. (2002) · Journal of Virology · doi:10.1128/jvi.76.24.12783-12791.2002 · Cited by 47
Barsov, E. V., & Hughes, S. H. (1996) · Journal of Virology · doi:10.1128/jvi.70.6.3922-3929.1996 · Cited by 47
Dunbar, C. E., Kohn, D. B., Karlsson, S., Barton, N. W., Brady, R. O., Cottler‐Fox, M., Crooks, G. M., Emmons, R. V. B., Esplin, J. A., Leitman, S. F., et al. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.2-231 · Cited by 47
Self-citationMokhtarieh, A. A., Cheong, S., Kim, S., Chung, B. H., & Lee, M. K. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.03.016 · Cited by 47
Cancer gene therapy: principles, problems, and perspectives
Herrmann, F. (1995) · Journal of Molecular Medicine · doi:10.1007/bf00188136 · Cited by 46
Human somatic cell gene therapy
Bank, A. (1996) · BioEssays · doi:10.1002/bies.950181210 · Cited by 46
Yan, H., Oommen, O. P., Yu, D., Hilborn, J. G., Qian, H., & Varghese, O. P. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201500695 · Cited by 45
Emulsion formulations as a vector for gene delivery in vitro and in vivo
Hara, T., Liu, F., Liu, D., & Huang, L. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(96)00467-x · Cited by 45
Retroviral Stem Cell Gene Therapy
Havenga, M. J. E., Hoogerbrugge, P. M., Valerio, D., & van Es, H. H. G. (1997) · Stem Cells · doi:10.1002/stem.150162 · Cited by 45
Interactions between exogenous and endogenous retroviruses
Rasmussen, H. B. (1997) · Journal of Biomedical Science · doi:10.1007/bf02255587 · Cited by 44
Isolated hepatocytes: use in experimental and clinical hepatology.
Strain, A. J. (1994) · Gut · doi:10.1136/gut.35.4.433 · Cited by 44
Tai, C.-M., Wang, W., Lai, Y.-H., Logg, C. R., Parker, W. B., Li, Y., Hong, J. S., Sorscher, E. J., Chen, T. C., & Kasahara, N. (2010) · Cancer Gene Therapy · doi:10.1038/cgt.2010.17 · Cited by 43
Bedoya, F., Frigault, M. J., & Maus, M. V. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2016.11.011 · Cited by 43
Josephs, S. F., Loudovaris, T., Dixit, A., Young, S. K., & Johnson, R. C. (1999) · Journal of Molecular Medicine · doi:10.1007/s001090050338 · Cited by 43
Chen, J., Reeves, L., Sanburn, N., Croop, J. M., Williams, D. A., & Cornetta, K. G. (2001) · Virology · doi:10.1006/viro.2001.0826 · Cited by 42
Human somatic gene therapy: progress and problems
Brenner, M. K. (1995) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1995.tb01171.x · Cited by 42
Large Animal Models for Stem and Progenitor Cell Analysis
Donahue, R. E., Kuramoto, K., & Dunbar, C. E. (2005) · Current Protocols in Immunology · doi:10.1002/0471142735.im22a01s69 · Cited by 41
Self-citationProgress in the Use of Gene Transfer Methods to Treat Genetic Blood Diseases
Williams, D. A., & Smith, F. O. (2000) · Human Gene Therapy · doi:10.1089/104303400750001372 · Cited by 41
Xenotransplantation: is the risk of viral infection as great as we thought?
Günzburg, W. H., & Salmons, B. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(00)01708-1 · Cited by 41
Wang, J.-M., Zheng, H., Blaivas, M., & Kurachi, K. (1997) · Blood · doi:10.1182/blood.v90.3.1075 · Cited by 41
Badie, B., Hunt, K. K., Economou, J. S., & Black, K. L. (1994) · Neurosurgery · doi:10.1227/00006123-199411000-00016 · Cited by 41
Gillet, J., Macadangdang, B. R., Fathke, R. L., Gottesman, M. M., & Kimchi‐Sarfaty, C. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-561-9_1 · Cited by 42
Characterisation of endogenous retrovirus in rodent cell lines used for production of biologicals
Shepherd, A. J., Wilson, N., & Smith, K. T. (2003) · Biologicals · doi:10.1016/s1045-1056(03)00065-4 · Cited by 40
Bunnell, B. A., Metzger, M. E., Byrne, E. R., Morgan, R. A., & Donahue, R. E. (1997) · Blood · doi:10.1182/blood.v89.6.1987 · Cited by 40
Self-citationGene Marking and Autologous Bone Marrow Transplantationa
Brenner, M. K., RILL, D. R., Moen, R. C., Krance, R. A., Heslop, H. E., Mirro, J., Anderson, W. F., & Ihle, J. N. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb21713.x · Cited by 40
Self-citationRole of Molecular Genetics in Hemophilia: From Diagnosis to Therapy
Jayandharan, G. R., Srivastava, A., & Srivastava, A. (2012) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0031-1300953 · Cited by 39
Cirielli, C., Inyaku, K., Capogrossi, M. C., Yuan, X., & Williams, J. A. (1999) · Journal of Neuro-Oncology · doi:10.1023/a:1006289505801 · Cited by 39
Aksentijevich, I., Pastan, I., Lunardi-Iskandar, Y., Gallo, R. C., Gottesman, M. M., & Thierry, A. R. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.9-1111 · Cited by 39
Long, Z., Lu, P. Y., Grooms, T., Mychkovsky, I., Westley, T., Fitzgerald, T. A., Sharma-Chibber, S., Shand, N., McGarrity, G. J., & Otto, E. (1999) · Human Gene Therapy · doi:10.1089/10430349950018490 · Cited by 39
Safety considerations in vector development.
Kappes, J. C., & Wu, X. (2001) · Somatic Cell and Molecular Genetics · doi:10.1023/a:1021082815013 · Cited by 41
Chen, J., Reeves, L., & Cornetta, K. G. (2001) · Human Gene Therapy · doi:10.1089/104303401450979 · Cited by 38
Fujii, G. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(99)00032-0 · Cited by 38
Sturtz, F. G., Waddell, K. S., Shulok, J. R., Chen, X., Caruso, M., Sanson, M., Snodgrass, H. R., & Platika, D. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.16-1945 · Cited by 38
Toward gene therapy for disorders of globin synthesis
Tisdale, J. F., & Sadelain, M. (2001) · Seminars in Hematology · doi:10.1016/s0037-1963(01)90033-2 · Cited by 38
Tsuboniwa, N., Morishita, R., Hirano, T., Fujimoto, J., Furukawa, S., Kikumori, M., Okuyama, Ä., & Kaneda, Y. (2001) · Human Gene Therapy · doi:10.1089/104303401300042366 · Cited by 38
Hematopoietic stem cell gene therapy: progress toward therapeutic targets
Vollweiler, J., Zielske, S. P., Reese, J., & Gerson, S. L. (2003) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704081 · Cited by 37
Impact of cell culture process changes on endogenous retrovirus expression
Brorson, K., de Wit, C., Hamilton, E., Mustafa, M. M., Swann, P. G., Kiss, R., Taticek, R., Polastri, G., Stein, K. E., & Xu, Y. (2002) · Biotechnology and Bioengineering · doi:10.1002/bit.10366 · Cited by 37
Liu, J. M., Young, N. S., Walsh, C., Cottier-Fox, M., Carter, C., Dunbar, C. E., Barrett, A. J., & Emmons, R. V. B. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.14-1715 · Cited by 37
Self-citationBiosafety in Handling Gene Transfer Vectors
Braun, A. G. (2006) · Current Protocols in Human Genetics · doi:10.1002/0471142905.hg1201s50 · Cited by 36
Minimal size MIDGE vectors improve transgene expression in vivo.
Schakowski, F., Gorschlüter, M., Buttgereit, P., Märten, A., von Lilienfeld‐Toal, M., Junghans, C., Schroff, M., König-Merediz, S. A., Ziske, C. G., Strehl, J., et al. (2007) · PubMed · Cited by 36
Kikuchi, E., Menéndez, S., Ozu, C., Ohori, M., Cordon‐Cardo, C., Logg, C. R., Kasahara, N., & Bochner, B. H. (2007) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7701013 · Cited by 36
Amit, M., Winkler, M. E., Menke, S., Brüning, E., Büscher, K., Denner, J., Haverich, A., Itskovitz‐Eldor, J., & Martin, U. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0046 · Cited by 36
Self-deleting retrovirus vectors for gene therapy
Russ, A., Friedel, C., Grez, M., & von Melchner, H. (1996) · Journal of Virology · doi:10.1128/jvi.70.8.4927-4932.1996 · Cited by 36
Sastry, L., Xu, Y., Duffy, L., Koop, S., Jasti, A. C., Roehl, H. H., Jolly, D. J., & Cornetta, K. G. (2005) · Human Gene Therapy · doi:10.1089/hum.2005.16.1227 · Cited by 35
Alpharetroviral Vectors: From a Cancer-Causing Agent to a Useful Tool for Human Gene Therapy
Suerth, J. D., Labenski, V., & Schambach, A. (2014) · Viruses · doi:10.3390/v6124811 · Cited by 35
Interleukin-12 plasmid DNA delivery using l-thyroxine-conjugated polyethylenimine nanocarriers
Dehshahri, A., Sadeghpour, H., Oskuee, R. K., Fadaei, M., Sabahi, Z., Alhashemi, S. H., & Mohazabieh, E. (2014) · Journal of Nanoparticle Research · doi:10.1007/s11051-014-2423-1 · Cited by 34
Sensitive Assays for Isolation and Detection of Simian Foamy Retroviruses
Khan, A. S., Sears, J. F., Müller, J., Galvin, T. A., & Shahabuddin, M. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.8.2678-2686.1999 · Cited by 34
Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation
Singh, A. K., Goerlich, C. E., Shah, A. M., Zhang, T., Tatarov, I., Ayares, D., Horvath, K. A., & Mohiuddin, M. M. (2022) · Transplant International · doi:10.3389/ti.2022.10171 · Cited by 33
Cornetta, K. G., Lin, T., Pellin, D., & Kohn, D. B. (2022) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2022.11.009 · Cited by 35
Kikuchi, E., Menéndez, S., Ozu, C., Ohori, M., Cordon‐Cardo, C., Logg, C. R., Kasahara, N., & Bochner, B. H. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0151 · Cited by 33
Kalle, C. V., Fehse, B., Layh‐Schmitt, G., Schmidt, M., Kelly, P. F., & Baum, C. (2004) · Seminars in Hematology · doi:10.1053/j.seminhematol.2004.07.007 · Cited by 33
Gene Delivery Systems in Surgery
Lyerly, H. K. (1993) · Archives of Surgery · doi:10.1001/archsurg.1993.01420230025004 · Cited by 33
Spada, S., Krebber, C., & Plückthun, A. (1997) · Biological Chemistry · doi:10.1515/bchm.1997.378.6.445 · Cited by 33
Non‐human viruses developed as therapeutic agent for use in humans
Koppers‐Lalic, D., & Hoeben, R. C. (2011) · Reviews in Medical Virology · doi:10.1002/rmv.694 · Cited by 32
Who’s afraid of replication-competent adenoviruses?
Fallaux, F. J., van der Eb, A. J., & Hoeben, R. C. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300902 · Cited by 32
Cornetta, K. G., Duffy, L., Feldman, S. A., Mackall, C. L., Davila, M. L., Curran, K. J., Junghans, R. P., Tang, J. Y., Kochenderfer, J. N., O'Cearbhaill, R. E., et al. (2018) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2018.08.006 · Cited by 31
Plasmid encoding interleukin‐4 in the amelioration of murine collagen‐induced arthritis
Kageyama, Y., Koide, Y., Uchijima, M., Nagata, T., Yoshida, A., Aoshi, T., Miura, T., Nagafusa, T., & Nagano, A. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20107 · Cited by 31
The Risk of Using Baboons as Transplant Donors: Exogenous and Endogenous Viruses
Allan, J. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09120.x · Cited by 31
Peptide-based cationic liposome-mediated gene delivery
Zhao, Y., Zhang, S., Cui, S., Wang, B., & Zhang, S. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.630387 · Cited by 30
Gene therapy for high grade gliomas
Alavi, J. Β., & Eck, S. L. (2001) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.1.2.239 · Cited by 30
Gene transfer into hematopoietic cells
Nienhuis, A. W., Bertran, J., Hargrove, P. W., Yang, Y., & Vanin, E. F. (1997) · Stem Cells · doi:10.1002/stem.5530150816 · Cited by 30
Amphotropic murine leukemia viruses induce spongiform encephalomyelopathy
Münk, C., Löhler, J., Prassolov, V., Just, U., Stockschläder, M., & Stocking, C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5837 · Cited by 30
Current status and prospects for gene therapy
Nathwani, A. C., Benjamin, R., Nienhuis, A. W., & Davidoff, A. M. (2004) · Vox Sanguinis · doi:10.1111/j.1423-0410.2004.00543.x · Cited by 30
Improved self-inactivating retroviral vectors derived from spleen necrosis virus
Olson, P., Nelson, S., & Dornburg, R. (1994) · Journal of Virology · doi:10.1128/jvi.68.11.7060-7066.1994 · Cited by 30
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Metadata
- Authors
- Donahue, R. E., Kessler, S. W., Bodine, D., McDonagh, K., Dunbar, C., Goodman, S., Agricola, B., Byrne, E., Raffeld, M., & Moen, R.
- Affiliations
- National Institutes of Health (US)
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1992-10-01
- Volume
- 176
- Issue
- 4
- Pages
- 1125-1135
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2119385
- OpenAlex
- W2132859839
- Cited by
- 532
- References
- 42
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2022: 8 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 10 · 2017: 7 · 2015: 8 · 2014: 11 · 2013: 5 · 2012: 9
- FWCI
- 17.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Health Sciences › Medicine › Surgery › Xenotransplantation and immune response
- Keywords
- Moloney murine leukemia virus, retroviral vectors, replication-competent virus, T-cell lymphoma, helper virus, retroviral gene transfer, CD34+ hematopoietic stem cells, bone marrow transplantation, rhesus monkeys, non-human primates, gene therapy safety, thymic lymphoma
- MeSH terms
- Animals, Antibodies, Monoclonal, Antigens, Differentiation, Base Sequence, Cells, Cultured, DNA, Neoplasm, DNA, Viral, Globins, Helper Viruses, Macaca mulatta, Molecular Sequence Data, Moloney murine leukemia virus, Oligodeoxyribonucleotides, Time Factors, Transfection, Virus Replication, Antigens, CD, Bone Marrow Transplantation, Lymphoma, T-Cell, Genome, Viral, Antigens, CD34
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