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Cited by 573

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Interleukin 4 is localized to and released by human mast cells.

Open access
Bradding, P, Feather, I H, Howarth, P H, Mueller, R, Roberts, J A, Britten, K, Bews, J P, Hunt, T C, Okayama, Y, Heusser, C H·1992·The Journal of experimental medicine
DOI 10.1084/jem.176.5.1381
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Abstract

Recent attention has focused on the T helper type 2 (Th2) lymphocyte as a source of interleukin 4 (IL-4) in allergic disease. However, Th2 cells themselves require a pulse of IL-4 to initiate this synthesis. Here we provide immunohistochemical evidence of IL-4 localization to human mast cells of the skin and respiratory tract, and demonstrate that immunoglobulin E-dependent stimulation of purified human lung mast cells leads to the rapid release of IL-4 into the extracellular environment. We propose that mast cell activation in an allergic response provides a rapid and local pulse of IL-4 into the local environment essential for the triggering of T lymphocytes into sustained IL-4 production and to initiate inflammatory cell accumulation and activation.

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Crossref · 10.1084/jem.176.5.1381

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Metadata

Authors
Bradding, P., Feather, I. H., Howarth, P. H., Mueller, R., Roberts, J. A., Britten, K., Bews, J. P., Hunt, T. C., Okayama, Y., & Heusser, C. H.
Venue
The Journal of experimental medicine
Publisher
Rockefeller University Press
Published
1992-11-01
Volume
176
Issue
5
Pages
1381-1386
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.176.5.1381
OpenAlex
W2151900684
Cited by
573
References
22
FWCI
19.21
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Interleukin 4 is localized to and released by human mast cells. https://app.cochat.ai/papers/10.1084/jem.176.5.1381
The paper
Bradding, P., Feather, I. H., Howarth, P. H., Mueller, R., Roberts, J. A., Britten, K., Bews, J. P., Hunt, T. C., Okayama, Y., & Heusser, C. H. (1992). Interleukin 4 is localized to and released by human mast cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.176.5.1381

Data sources

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.