The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses.
Open accessAbstract
Mast cell-associated mediators are generally classified into two groups: the preformed mediators, which are stored in the cells' cytoplasmic granules and are released upon exocytosis, and the newly synthesized mediators, which are not stored but are produced and secreted only after appropriate stimulation of the cell. We now report that tumor necrosis factor alpha (TNF-alpha)/cachectin represents a new type of mast cell-associated mediator, in that IgE-dependent mast cell activation results in the rapid release of preformed stores of the cytokine followed by the synthesis and sustained release of large quantities of newly formed TNF-alpha. We also demonstrate that challenge with specific antigen induces higher levels of TNF-alpha mRNA at skin sites sensitized with IgE in normal mice or mast cell-reconstituted genetically mast cell-deficient WBB6F1-W/W1' mice than at identically treated sites in WBB6F1-W/W1' mice that are devoid of mast cells. These findings identify mast cells as a biologically significant source of TNF-alpha/cachectin during IgE-dependent responses and define a mechanism whereby stimulation of mast cells via the FC epsilon RI can account for both the rapid and sustained release of this cytokine.
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Cites
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The Biology Of Cachectin/TNF: A Primary Mediator Of The Host Response
Beutler, B. (1989) · Annual Review of Immunology · doi:10.1146/annurev.immunol.7.1.625 · Cited by 1,697
Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin
Gordon, J. R., & Galli, S. J. (1990) · Nature · doi:10.1038/346274a0 · Cited by 985
Self-citationMonoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization.
Liu, F., Bohn, J., Ferry, E. L., Yamamoto, H., Molinaro, C. A., Sherman, L. A., Klinman, N. R., & Katz, D. H. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.124.6.2728 · Cited by 631
Burd, P. R., Rogers, H. W., Gordon, J. R., Martin, C. A., Jayaraman, S., Wilson, S. D., Dvorak, A. M., Galli, S. J., & Dorf, M. E. (1989) · The Journal of experimental medicine · doi:10.1084/jem.170.1.245 · Cited by 539
Self-citationWodnar-Filipowicz, A., Heusser, C. H., & Moroni, C. (1989) · Nature · doi:10.1038/339150a0 · Cited by 480
Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor.
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Degranulation of human mast cells induces an endothelial antigen central to leukocyte adhesion.
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Cited by
Malaviya, R., Ikeda, T., Ross, E., & Abraham, S. N. (1996) · Nature · doi:10.1038/381077a0 · Cited by 1,123
The diverse potential effector and immunoregulatory roles of mast cells in allergic disease
Williams, C. M. M., & Galli, S. J. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.106485 · Cited by 355
Self-citationMast cell–derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection
McLachlan, J. B., Hart, J. P., Pizzo, S. V., Shelburne, C. P., Staats, H. F., Gunn, M. D., & Abraham, S. N. (2003) · Nature Immunology · doi:10.1038/ni1005 · Cited by 317
Impaired mast cell-dependent natural immunity in complement C3-deficient mice
Prodeus, A. P., Zhou, X., Maurer, M., Galli, S. J., & Carroll, M. C. (1997) · Nature · doi:10.1038/36586 · Cited by 277
Self-citationMicroglia and mast cells: two tracks on the road to neuroinflammation
Skaper, S. D., Giusti, P., & Facci, L. (2012) · The FASEB Journal · doi:10.1096/fj.11-197194 · Cited by 235
Metadata
- Authors
- Gordon, J. R., & Galli, S. J.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1991-07-01
- Volume
- 174
- Issue
- 1
- Pages
- 103-107
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2161948102
- Cited by
- 363
- References
- 14
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses. https://app.cochat.ai/papers/10.1084/jem.174.1.103
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- Gordon, J. R., & Galli, S. J. (1991). Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses. The Journal of experimental medicine. https://doi.org/10.1084/jem.174.1.103
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