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Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells.
Open accessAbstract
We have previously shown that antigen-induced eosinophil recruitment into the tissue of sensitized mice is mediated by CD4+ T cells and interleukin 5. To determine whether interferon gamma (IFN-gamma) regulates antigen-induced eosinophil recruitment into the tissue, we studied the effect of recombinant (r) murine IFN-gamma and of anti-IFN-gamma monoclonal antibody (mAb) on the eosinophil infiltration of the trachea induced by antigen inhalation in mice. The intraperitoneal administration of rIFN-gamma prevented antigen-induced eosinophil infiltration in the trachea of sensitized mice. The administration of rIFN-gamma also decreased antigen-induced CD4+ T cell but not CD8+ T cell infiltration in the trachea. On the other hand, pretreatment with anti-IFN-gamma mAb enhanced antigen-induced eosinophil and CD4+ T cell infiltration in the trachea. These results indicate that IFN-gamma regulates antigen-induced eosinophil recruitment into the tissue by inhibiting CD4+ T cell infiltration.
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Cited by
Lymph node trafficking and antigen presentation by endobronchial eosinophils
Shi, H.-Z., Humbles, A., Gerard, C., Jin, Z., & Weller, P. F. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8945 · Cited by 326
Afanasyeva, M., Wang, Y., Kaya, Z., Park, S., Zilliox, M. J., Schofield, B. H., Hill, S. L., & Rose, N. R. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)61685-9 · Cited by 175
Sogut, A., Yilmaz, O., Kirmaz, C., Ozbilgin, K., Onur, E., Celik, O., Pinar, E., Vatansever, S., Dinc, G., & Yuksel, H. (2012) · International Archives of Allergy and Immunology · doi:10.1159/000329159 · Cited by 33
Metadata
- Authors
- Iwamoto, I., Nakajima, H., Endo, H., & Yoshida, S.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1993-02-01
- Volume
- 177
- Issue
- 2
- Pages
- 573-576
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2131227262
- Cited by
- 302
- References
- 0
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells. https://app.cochat.ai/papers/10.1084/jem.177.2.573
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- Iwamoto, I., Nakajima, H., Endo, H., & Yoshida, S. (1993). Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.177.2.573
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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