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Cited by 326

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Lymph node trafficking and antigen presentation by endobronchial eosinophils

Open access
Shi, Huan-Zhong, Humbles, Alison, Gerard, Craig, Jin, Zhuang, Weller, Peter F.·2000·Journal of Clinical Investigation
DOI 10.1172/jci8945
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Abstract

Because eosinophils recruited into the airways in allergic diseases are exposed to inhaled allergens, we evaluated whether eosinophils within the endobronchial lumen can function in vivo as antigen-presenting cells for inhaled antigens. We recovered eosinophils from the airways after aerosol antigen challenge in sensitized mice or from the peritoneal cavities of IL-5 transgenic mice and fluorescently labeled these cells ex vivo. These labeled cells, instilled intratracheally into normal mice, migrated into draining paratracheal lymph nodes and localized to T cell-rich paracortical areas. The homing of airway eosinophils to lymph nodes was not governed by eotaxin, because CCR3(-/-) and CCR3(+/+) eosinophils migrated identically. Airway eosinophils, recovered after inhalational antigen challenge in sensitized mice, expressed MHC class II and costimulatory CD80 and CD86 proteins and functioned in vitro as CD80- and CD86-dependent, antigen-specific, antigen-presenting cells. Moreover, when instilled into the airways of antigen-sensitized recipient mice, airway eosinophils recovered after inhalational antigen challenge stimulated antigen-specific CD4(+) T cell proliferation within paratracheal lymph nodes. Thus, eosinophils within the lumina of airways can process inhaled antigens, traffic to regional lymph nodes, and function in vivo as antigen-presenting cells to stimulate responses of CD4(+) T cells.

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Metadata

Authors
Shi, H.-Z., Humbles, A., Gerard, C., Jin, Z., & Weller, P. F.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2000-04-01
Volume
105
Issue
7
Pages
945-953
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci8945
OpenAlex
W2032052491
Cited by
326
References
31
FWCI
9.64
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Lymph node trafficking and antigen presentation by endobronchial eosinophils. https://app.cochat.ai/papers/10.1172/jci8945
The paper
Shi, H.-Z., Humbles, A., Gerard, C., Jin, Z., & Weller, P. F. (2000). Lymph node trafficking and antigen presentation by endobronchial eosinophils. Journal of Clinical Investigation. https://doi.org/10.1172/jci8945

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.