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Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.
Open accessAbstract
Anticardiolipin antibodies (aCL) derived from the sera of individuals exhibiting the antiphospholipid syndrome (APS) directly bind to beta 2-glycoprotein I (beta 2-GPI), which is adsorbed to an oxidized polystyrene surface. Oxygen atoms were introduced on a polystyrene surface by irradiation with electron or gamma-ray radiation. X-ray photoelectron spectroscopy revealed the irradiated surfaces were oxidized to generate C-O and C = O moieties. aCL derived from either APS patients or (NZW x BXSB)F1 mice bound to beta 2-GPI coated on the irradiated plates, depending on the radiation dose. Antibody binding to beta 2-GPI on the irradiated plates was competitively inhibited by simultaneous addition of cardiolipin (CL)-coated latex beads mixed together with beta 2-GPI but were unaffected by addition of excess beta 2-GPI, CL micelles, or CL-coated latex beads alone. There was a high correlation between binding values of aCL in sera from 40 APS patients obtained by the anti-beta 2-GPI enzyme-linked immunosorbent assay (ELISA) using the irradiated plates and those by the beta 2-GPI-dependent aCL ELISA. Therefore, aCL have specificity for an epitope on beta 2-GPI. This epitope is expressed by a conformational change occurring when beta 2-GPI interacts with an oxygen-substituted solid phase surface.
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Cited by
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Biasiolo, A., Pegoraro, C., Cucchini, U., Noventa, F., Iliceto, S., & Pengo, V. (2005) · Thrombosis and Haemostasis · doi:10.1160/th04-12-0839 · Cited by 320
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Zwaal, R. F. A., Comfurius, P., & Bevers, E. M. (1998) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0304-4157(98)00018-5 · Cited by 294
Otomo, K., Atsumi, T., Amengual, O., Fujieda, Y., Kato, M., Oku, K., Horita, T., Yasuda, S., & Koike, T. (2012) · Arthritis & Rheumatism · doi:10.1002/art.33340 · Cited by 254
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Metadata
- Authors
- Matsuura, E., Igarashi, Y., Yasuda, T., Triplett, D. A., & Koike, T.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1994-02-01
- Volume
- 179
- Issue
- 2
- Pages
- 457-462
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2160872701
- Cited by
- 529
- References
- 0
- FWCI
- 31.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Matsuura, E., Igarashi, Y., Yasuda, T., Triplett, D. A., & Koike, T. (1994). Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. The Journal of experimental medicine. https://doi.org/10.1084/jem.179.2.457
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