The DOI matches its Crossref record.
Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.
Open accessAbstract
The gram negative, microaerophilic bacterium Helicobacter pylori colonizes the human gastric mucosa and establishes a chronic infection that is tightly associated with atrophic gastritis, peptic ulcer, and gastric carcinoma. Cloning of the H. pylori cytotoxin gene shows that the protein is synthesized as a 140-kD precursor that is processed to a 94-kD fully active toxin. Oral administration to mice of the purified 94-kD protein caused ulceration and gastric lesions that bear some similarities to the pathology observed in humans. The cloning of the cytotoxin gene and the development of a mouse model of human gastric disease will provide the basis for the understanding of H. pylori pathogenesis and the development of therapeutics and vaccines.
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Citations
Cited by
Pathogenesis of Helicobacter pylori Infection
Kusters, J. G., van Vliet, A. H. M., & Kuipers, E. J. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00054-05 · Cited by 2,526
Ernst, P. B., & Gold, B. D. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.615 · Cited by 554
Rhead, J. L., Letley, D. P., Mohammadi, M., Hussein, N., Mohagheghi, M. A., Eshagh Hosseini, M., & Atherton, J. C. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.056 · Cited by 435
Metadata
- Authors
- Telford, J. L., Ghiara, P., Dell'Orco, M., Comanducci, M., Burroni, D., Bugnoli, M., Tecce, M. F., Censini, S., Covacci, A., & Xiang, Z.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1994-05-01
- Volume
- 179
- Issue
- 5
- Pages
- 1653-1658
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2155237708
- Cited by
- 586
- References
- 0
- FWCI
- 41.99
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. https://app.cochat.ai/papers/10.1084/jem.179.5.1653
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- Telford, J. L., Ghiara, P., Dell'Orco, M., Comanducci, M., Burroni, D., Bugnoli, M., Tecce, M. F., Censini, S., Covacci, A., & Xiang, Z. (1994). Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. The Journal of experimental medicine. https://doi.org/10.1084/jem.179.5.1653
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
