The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development.
Open accessAbstract
CD44 is implicated in the regulation of tumor growth and metastasis but the mechanism by which expression of different CD44 isoforms determines the rate of primary and secondary tumor growth remains unclear. In the present study we use a human melanoma transfected with wild-type and mutant forms of CD44 to determine which functional property of the CD44 molecule is critical in influencing tumor behavior. We show that expression of a wild-type CD44 isoform that binds hyaluronic acid augments the rapidity of tumor formation by melanoma cells in vivo, whereas expression of a CD44 mutant, which does not mediate cell attachment to hyaluronate, fails to do so. The importance of CD44-hyaluronate interaction in tumor development is underscored by the differential inhibitory effect of soluble wild-type and mutant CD44-Ig fusion proteins on melanoma growth in vivo. Whereas local administration of a mutant, nonhyaluronate binding, CD44-Ig fusion protein has no effect on subcutaneous melanoma growth in mice, infusion of wild-type CD44-Ig is shown to block tumor development. Taken together, these observations suggest that the tumor growth promoting property of CD44 is largely dependent on its ability to mediate cell attachment to hyaluronate.
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Cites
CD44 is the principal cell surface receptor for hyaluronate
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Self-citationA new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells
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Proteoglycans as modulators of growth factor activities
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Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.
Aruffo, A., & Seed, B. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8573 · Cited by 784
Self-citationStamenkovic, I., Amiot, M., Pesando, J. M., & Seed, B. (1989) · Cell · doi:10.1016/0092-8674(89)90638-7 · Cited by 672
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Cited by
Hyaluronan: from extracellular glue to pericellular cue
Toole, B. P. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1391 · Cited by 2,125
Yu, Q., & Stamenkovic, I. (2000) · Genes & Development · doi:10.1101/gad.14.2.163 · Cited by 1,754
Self-citationExpression of CD44 in Apc and TcfMutant Mice Implies Regulation by the WNT Pathway
Wielenga, V. J. M., Smits, R., Korinek, V., Smit, L., Kielman, M., Fodde, R., Clevers, H., & Pals, S. T. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65297-2 · Cited by 433
Mohamadzadeh, M., DeGrendele, H., Arizpe, H., Estess, P., & Siegelman, M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1604 · Cited by 313
Mimeault, M., & Batra, S. K. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00885.x · Cited by 38
Metadata
- Authors
- Bartolazzi, A., Peach, R., Aruffo, A., & Stamenkovic, I.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1994-07-01
- Volume
- 180
- Issue
- 1
- Pages
- 53-66
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2143762419
- Cited by
- 331
- References
- 38
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bartolazzi, A., Peach, R., Aruffo, A., & Stamenkovic, I. (1994). Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development. The Journal of experimental medicine. https://doi.org/10.1084/jem.180.1.53
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
