The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide.
Open accessAbstract
CD11c/CD18 is a member of the leukocyte integrin family, heterodimeric adhesion molecules that interact with a diverse repertoire of ligands, including bacterial lipopolysaccharide (LPS). Their role as signal transducing receptors remains uncertain. We used a heterologous expression system to determine if CD11c/CD18 was capable of initiating signal transduction in response to LPS-binding, as assessed by the induced translocation of nuclear factor-kappa B. We have previously reported that Chinese hamster ovary (CHO)-K1 fibroblasts, normally unresponsive to LPS, acquire serum-dependent macrophage-like responses to LPS when transfected with CD14 (Golenbock, D.T., Y. Liu, F. Millham, M. Freeman, and R. Zoeller. 1993. J. Biol. Chem. 268:22055-22059), a known LPS receptor. In contrast, CHO cells acquired serum-independent responses to Gram-negative bacteria and LPS when transfected with CD11c/CD18 (CHO/CD11c). In comparison to CHO cells transfected with CD14 (CHO/CD14), responses in CHO/CD11c cells were slower, required higher endotoxin concentrations for maximal response, and were not inhibited by the presence of antibodies to CD14. CD11c/CD18 is, thus, the second phagocyte receptor, in addition to CD14, which has been shown to have the capacity to activate cells after binding to LPS. The function of this receptor in normal phagocytes may be limited to the recognition of LPS in infected tissues, where LPS-CD14 interactions are not favored because of the absence of serum proteins.
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Cites
Integrins: A family of cell surface receptors
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CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
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LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins
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Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14.
Hailman, E., Lichenstein, H. S., Wurfel, M. M., Miller, D. S., Johnson, D. A., Kelley, M., Busse, L. A., Zukowski, M. M., & Wright, S. D. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.1.269 · Cited by 743
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Soluble CD14 participates in the response of cells to lipopolysaccharide.
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Cited by
Sanlioglu, S., Williams, C. M., Samavati, L., Butler, N. S., Wang, G., McCray, P. B., Ritchie, T. C., Hunninghake, G. W., Zandi, E., & Engelhardt, J. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102061200 · Cited by 395
Potential Role of Endotoxin as a Proinflammatory Mediator of Atherosclerosis
Stoll, L. L., Denning, G. M., & Weintraub, N. L. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000147534.69062.dc · Cited by 288
Haworth, R., Platt, N., Keshav, S., Hughes, D., Darley, E., Suzuki, H., Kurihara, Y., Kodama, T., & Gordon, S. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1431 · Cited by 274
Bi, Y., Seabold, J. M., Kaar, S. G., Ragab, A. A., Goldberg, V. M., Anderson, J. M., & Greenfield, E. M. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.11.2082 · Cited by 227
Integrin signalling in neutrophils and macrophages
Berton, G., & Lowell, C. A. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(99)00003-0 · Cited by 224
Metadata
- Authors
- Ingalls, R. R., & Golenbock, D. T.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1995-04-01
- Volume
- 181
- Issue
- 4
- Pages
- 1473-1479
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2142683017
- Cited by
- 293
- References
- 43
- FWCI
- 10.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ingalls, R. R., & Golenbock, D. T. (1995). CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide. The Journal of experimental medicine. https://doi.org/10.1084/jem.181.4.1473
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
