The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Bcl-XL and Bcl-2 repress a common pathway of cell death.
Open accessAbstract
The effect of Bcl-xL upon the developmental death of T cells was assessed by generating transgenic mice that expressed Bcl-xL within all thymocyte subsets. Bcl-xL protected thymocytes from a variety of apoptotic stimuli, including gamma irradiation, glucocorticoids, and anti-CD3 treatment. Bcl-xL altered thymocyte maturation, resulting in increased numbers of CD3int/hi and CD4-8+ thymocytes. Overall, the phenotype of Bcl-xL transgenics was essentially indistinguishable from a Bcl-2 transgenic model. Overexpression of Bcl-xL or Bcl-2 resulted in the down-regulation of the other molecule, providing further evidence of their reciprocal regulation. In a genetic test of redundancy, the Bcl-xL transgene rescued mature T cells in Bcl-2 null mice. Immunoprecipitation indicated that Bcl-xL, like Bcl-2, heterodimerized with the death-promoting molecule Bax in thymocytes. This in vivo model argues that Bcl-xL, like Bcl-2, functions in a common pathway to repress cell death.
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Citations
Cites
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003
Self-citation
Cited by
Catlett-Falcone, R., Landowski, T. H., Oshiro, M. M., Turkson, J., Levitzki, A., Savino, R., Ciliberto, G., Moscinski, L., Fernández-Luna, J. L., Nuñez, G., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80011-4 · Cited by 1,638
Rathmell, J. C., Heiden, M. G. V., Harris, M. H., Frauwirth, K. A., & Thompson, C. B. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00066-6 · Cited by 467
Self-citationIL-7 Enhances the Survival and Maintains the Size of Naive T Cells
Rathmell, J. C., Farkash, E. A., Gao, W., & Thompson, C. B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.12.6869 · Cited by 459
Self-citationDynamic programming of CD8+ T lymphocyte responses
van Stipdonk, M. J. B., Hardenberg, G., Bijker, M. S., Lemmens, E. E., Droin, N. M., Green, D. R., & Schoenberger, S. P. (2003) · Nature Immunology · doi:10.1038/ni912 · Cited by 401
CD95-Induced Apoptosis of Lymphocytes in an Immune Privileged Site Induces Immunological Tolerance
Griffith, T. S., Yu, X., Herndon, J. M., Green, D. R., & Ferguson, T. A. (1996) · Immunity · doi:10.1016/s1074-7613(00)80305-2 · Cited by 382
Metadata
- Authors
- Chao, D. T., Linette, G. P., Boise, L. H., White, L. S., Thompson, C. B., & Korsmeyer, S. J.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1995-09-01
- Volume
- 182
- Issue
- 3
- Pages
- 821-828
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2131616553
- Cited by
- 395
- References
- 1
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Bcl-XL and Bcl-2 repress a common pathway of cell death. https://app.cochat.ai/papers/10.1084/jem.182.3.821
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- Chao, D. T., Linette, G. P., Boise, L. H., White, L. S., Thompson, C. B., & Korsmeyer, S. J. (1995). Bcl-XL and Bcl-2 repress a common pathway of cell death. The Journal of experimental medicine. https://doi.org/10.1084/jem.182.3.821
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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