Dynamic programming of CD8+ T lymphocyte responses
Abstract
The initial encounter with an antigen-presenting cell (APC) is the primary force behind the expansion, differentiation and survival of naive T cells. Using an APC that permits temporal control of priming, we examined whether the duration of antigenic stimulation can influence the functional development of CD8+ cytotoxic T lymphocytes (CTLs) in vivo. Whereas CTLs given a 4-h stimulus underwent an abortive clonal expansion with transient surface CD25 expression, those given a 20-h stimulus sustained CD25 up-regulation, proliferated extensively, and efficiently mediated destruction of peripheral target tissues. Our results show that an instructional program preceding the first cell division integrates differences in signal strength into the decision to activate versus tolerize specific CTL clones.
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Cell lines expressing MHCI-peptide conjugates, such as SAMBOK (MEC.B7.SigOVA) or RMA-S, can be used to stimulate CD8 T cells because they exhibit efficient presentation of peptide on MHCI.
“Additionally, cells directly infected with bacteria/virus or cell lines expressing MHCI-peptide conjugates, such as SAMBOK (MEC.B7.SigOVA) [233] or RMA-S, can be used to stimulate CD8 T cells, as these cells exhibit efficient presentation of peptide on MHCI.”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [233]
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Self-citation
- Authors
- van Stipdonk, M. J. B., Hardenberg, G., Bijker, M. S., Lemmens, E. E., Droin, N. M., Green, D. R., & Schoenberger, S. P.
- Affiliations
- Leiden University Medical Center (NL)
- La Jolla Institute for Immunology (US)
- Corresponding author
- Schoenberger, Stephen P.
- Venue
- Nature Immunology
- Published
- 2003-03-17
- Volume
- 4
- Issue
- 4
- Pages
- 361-365
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2008354811
- Cited by
- 401
- References
- 27
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 2 · 2023: 9 · 2022: 7 · 2021: 9 · 2020: 13 · 2019: 3 · 2018: 13 · 2017: 8 · 2016: 15 · 2015: 6 · 2014: 19 · 2013: 9 · 2012: 21
- FWCI
- 12.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- CD8+ T cells, cytotoxic T lymphocytes, T cell activation, antigen-presenting cells, clonal expansion, CD25 expression, signal strength, T cell tolerance, T cell differentiation, dynamic programming
- MeSH terms
- Animals, Cell Division, Cell Movement, Interleukin-2, CD8-Positive T-Lymphocytes, Mice
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