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Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.
Open accessAbstract
We have identified a serine/threonine kinase that is rapidly activated during Fas-mediated apoptosis. Fas-activated serine/threonine kinase (FAST) is phosphorylated on serine and threonine residues in Jurkat cells. In response to Fas ligation, it is rapidly dephosphorylated and concomitantly activated to phosphorylate TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation, suggesting a role in signaling downstream events in the apoptotic program. Our results introduce Fast and TIA-1 as components of a molecular cascade involved in signaling Fas-mediated apoptosis.
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Cites
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Kedersha, N. L., Gupta, M., Li, W., Miller, I., & Anderson, P. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.7.1431 · Cited by 1,256
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Tian, Q., Frierson, H. F., Krystal, G. W., & Moskaluk, C. A. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65419-3 · Cited by 408
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Prasad, N. K. A., Papoff, G., Zeuner, A., Bonnin, E., Kazatchkine, M. D., Ruberti, G., & Kaveri, S. V. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3781 · Cited by 279
Metadata
- Authors
- Tian, Q., Taupin, J., Elledge, S., Robertson, M., & Anderson, P.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1995-09-01
- Volume
- 182
- Issue
- 3
- Pages
- 865-874
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2145038749
- Cited by
- 167
- References
- 1
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. https://app.cochat.ai/papers/10.1084/jem.182.3.865
- The paper
- Tian, Q., Taupin, J., Elledge, S., Robertson, M., & Anderson, P. (1995). Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. The Journal of experimental medicine. https://doi.org/10.1084/jem.182.3.865
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
